YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30262307, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	461 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30262307, gi|....

Description	E-value	Query Range	Subject Range
gi\|42527474, gi\|... - gi\|42527474\|ref\|NP_972572.1\| sigma-54 dependent transcriptional regulator/response regulator [Trepon...	1.0E-94	[19..461]	[1..450]
gi\|158320115, gi... - gi\|158320115\|ref\|YP_001512622.1\| two component, sigma54 specific, Fis family transcriptional regulat...	1.0E-93	[19..460]	[1..450]
gi\|78221996, gi\|... - gi\|78221996\|ref\|YP_383743.1\| two component, sigma54 specific, Fis family transcriptional regulator [...	2.0E-93	[19..460]	[1..452]
gi\|134299175, gi... - gi\|88944680\|ref\|ZP_01147905.1\| Helix-turn-helix, Fis-type [Desulfotomaculum reducens MI-1], gi\|88925...	9.0E-93	[19..459]	[2..452]
gi\|46581622, gi\|... - gi\|46581622\|ref\|YP_012430.1\| sigma-54 dependent transcriptional regulator/response regulator [Desulf... gi\|241908558, gi... - gi\|241908558\|ref\|ZP_04793124.1\| two component, sigma54 specific, transcriptional regulator, Fis fami...	3.0E-92	[23..459]	[7..457]
gi\|120601219, gi... - gi\|120601219\|ref\|YP_965619.1\| two component, sigma54 specific, Fis family transcriptional regulator ...	6.0E-92	[23..459]	[7..457]
gi\|222054817, gi... - gi\|222054817\|ref\|YP_002537179.1\| two component, sigma54 specific, transcriptional regulator, Fis fam...	7.0E-92	[23..461]	[6..478]
gi\|146398219, gi... - gi\|88934576\|ref\|ZP_01140218.1\| Helix-turn-helix, Fis-type [Geobacter uraniumreducens Rf4], gi\|889187...	8.0E-92	[19..461]	[1..457]
gi\|50875265, gi\|... - gi\|51244228\|ref\|YP_064112.1\| Ntr family two-component response regulator [Desulfotalea psychrophila ...	9.0E-92	[21..459]	[2..443]
gi\|77546022, gi\|... - gi\|77919939\|ref\|YP_357754.1\| two component signal transduction response regulator [Pelobacter carbin...	1.0E-91	[21..461]	[2..454]

Back

Predicted Domain #1

Region A:
Residues: [1-393]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLLAVSTQE VIEAILGSID EAIHAVDENG ITIFYNTVAA KHDGSKIEKV LGKHLLEAFP  60
   61 SLSRETSTLM KVLDTKKPIV HQVQHYQNLN GEDICTVNTT LPIFIDGNIA GAVEIAKDYS 120
  121 TVQKLTDTIV DLQSKIKRSS RKKAIKKHVA FETIVTNDAR FKQTKELAQK VAPTDANVLI 180
  181 YGETGTGKEL FVQAIHEASK RKNKPFIAQN CAALPESLLE SLLFGTTKGS YTGAIERAGL 240
  241 FELVDGGTLF LDELNSMPLD LQAKMLRVLE DGVIRRIGDN KTRKVDVRVI TAMNQPPEVC 300
  301 LKENKIRTDL YYRLNVFSLY IPPLRERTED VLLLASYFLK EYNKSYKKGV LQMDKEAKER 360
  361 LQSYQWPGNV RELKHTIEHA VIIAEGNTLT ANC

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.154902
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
hydrolase activity	1.18053993810305	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
purine ribonucleotide binding	0.0324692870996578	bayes_pls_golite062009
ribonucleotide binding	0.0319901144782286	bayes_pls_golite062009
purine nucleotide binding	0.0199205367873159	bayes_pls_golite062009
nucleotide binding	0.00540039127746217	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [394-461]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPRTFRKESF PKKKSILPLR EALHQTEKEL IDQALIETEG NILQAAKMLG IPRQTLQYKL  60
   61 SKYDKTAE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	77.69897
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: