YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30264256, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	286 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30264256, gi|....

Description	E-value	Query Range	Subject Range
FOLD_MOOTA - Bifunctional protein FolD OS=Moorella thermoacetica (strain ATCC 39073) GN=folD PE=3 SV=1	0.0	[1..280]	[1..280]
FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD... sp\|A0LE04\|FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...	0.0	[2..282]	[1..282]
FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis (strain 168) GN=folD PE=3 SV=1 FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis GN=folD PE=3 SV=1 gi\|221323877 - gi\|221323877\|ref\|ZP_03605171.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221319601 - gi\|221319601\|ref\|ZP_03600895.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221314678 - gi\|221314678\|ref\|ZP_03596483.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su...	0.0	[1..280]	[1..280]
FOLD_BACAH - Bifunctional protein FolD OS=Bacillus thuringiensis (strain Al Hakam) GN=folD PE=3 SV=1 gi\|228916817, gi... - gi\|228916817\|ref\|ZP_04080382.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... FOLD_BACHK - Bifunctional protein FolD OS=Bacillus thuringiensis subsp. konkukian GN=folD PE=3 SV=1 FOLD_BACC3 - Bifunctional protein FolD OS=Bacillus cereus (strain 03BB102) GN=folD PE=3 SV=1 gi\|229186424, gi... - gi\|229186424\|ref\|ZP_04313588.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus B... gi\|228659836, gi... - gi\|229123701\|ref\|ZP_04252896.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus 9... FOLD_BACHK - Bifunctional protein FolD OS=Bacillus thuringiensis subsp. konkukian (strain 97-27) GN=folD PE=3 SV=... gi\|228947898, gi... - gi\|228947898\|ref\|ZP_04110185.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228830517, gi... - gi\|228929227\|ref\|ZP_04092254.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... FOLD_BACC0 - Bifunctional protein FolD OS=Bacillus cereus (strain AH820) GN=folD PE=3 SV=1 gi\|196046285, gi... - gi\|196046285\|ref\|ZP_03113511.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc... gi\|196034934, gi... - gi\|196034934\|ref\|ZP_03102341.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc...	0.0	[1..286]	[1..286]
FOLD_BACCZ - Bifunctional protein FolD OS=Bacillus cereus (strain ZK / E33L) GN=folD PE=3 SV=1	0.0	[1..286]	[1..286]
FOLD_BACC1 - Bifunctional protein FolD OS=Bacillus cereus (strain ATCC 10987 / NRS 248) GN=folD PE=3 SV=1	0.0	[1..286]	[1..286]
gi\|228987372, gi... - gi\|228987372\|ref\|ZP_04147492.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|229157780, gi... - gi\|229157780\|ref\|ZP_04285855.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus A... gi\|47553855, gi\|... - gi\|47569440\|ref\|ZP_00240121.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl...	0.0	[1..286]	[1..286]
gi\|37958858 - gi\|37958858\|gb\|AAP51122.1\| putative methylenetetrahydrofolate dehydrogenase [uncultured bacterium]	0.0	[1..280]	[1..280]
SO1792 - methylenetetrahydrofolate dehydrogenase/methylenetetrahydrofolate cyclohydrolase FOLD_SHEON - Bifunctional protein FolD OS=Shewanella oneidensis (strain MR-1) GN=folD PE=3 SV=1	0.0	[1..282]	[1..283]
gi\|228960449, gi... - gi\|228960449\|ref\|ZP_04122100.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228954467, gi... - gi\|228954467\|ref\|ZP_04116492.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228818268, gi... - gi\|228941342\|ref\|ZP_04103894.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228711419, gi... - gi\|229071688\|ref\|ZP_04204904.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus F... gi\|229047877, gi... - gi\|229047877\|ref\|ZP_04193453.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus A... gi\|228980867, gi... - gi\|228980867\|ref\|ZP_04141171.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228974274, gi... - gi\|228974274\|ref\|ZP_04134843.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus thuringi... gi\|228636584, gi... - gi\|229146756\|ref\|ZP_04275121.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus B... gi\|229129461, gi... - gi\|229129461\|ref\|ZP_04258432.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus B... gi\|229111656, gi... - gi\|229111656\|ref\|ZP_04241206.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus R... gi\|228701855, gi... - gi\|229081440\|ref\|ZP_04213940.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus R... gi\|228590970, gi... - gi\|229192393\|ref\|ZP_04319356.1\| Methylenetetrahydrofolate dehydrogenase (NADP(+)) [Bacillus cereus A... FOLD_BACCR - Bifunctional protein FolD OS=Bacillus cereus (strain ATCC 14579 / DSM 31 / JCM 2152 / NBRC 15305 / N... gi\|206971009, gi... - gi\|206971009\|ref\|ZP_03231960.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyc...	0.0	[1..286]	[1..286]

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Predicted Domain #1

Region A:
Residues: [1-286]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVAVIIKGNE VAEKKRAQLK EEVVKLKEQG IVPGLAVILV GEDPASRSYV KGKEKGCEQV  60
   61 GIYSELIEFP ETITEERLLA EIDRLNGDDR INGILVQLPL PKHIEEKAII ERISPEKDVD 120
  121 GFHPISVGRM MTGQDTFLPC TPHGIVELVK ETNLDISGKH VVVIGRSNIV GKPVGQLFLN 180
  181 ENATVTYCHS KTQNMKELTK LADILIVAVG RPKMVTADYI KEGAVVIDVG VNRLETGKLC 240
  241 GDVDFDNVLD VASYITPVPK GVGPMTITML LHNTVESAKR AGVVCK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	113.0
Match:	1b0aA
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.54983447672782	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.66605122152932	bayes_pls_golite062009
malate dehydrogenase activity	2.43636049081724	bayes_pls_golite062009
catalytic activity	2.0643953589843	bayes_pls_golite062009
transcription regulator activity	1.95832530533882	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	1.95551536198286	bayes_pls_golite062009
DNA binding	1.70073234884672	bayes_pls_golite062009
binding	1.57522146187634	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.54527841865655	bayes_pls_golite062009
nucleic acid binding	1.47211855405194	bayes_pls_golite062009
malic enzyme activity	1.39067036188188	bayes_pls_golite062009
transcription factor activity	0.9895904275677	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	0.66392365734856	bayes_pls_golite062009
cyclohydrolase activity	0.129148522173579	bayes_pls_golite062009
ligase activity	0.0191278372003161	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: