YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30262746, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	398 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30262746, gi|....

Description	E-value	Query Range	Subject Range
gi\|126096730, gi... - gi\|126207938\|ref\|YP_001053163.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog... gi\|32034768 - gi\|32034768\|ref\|ZP_00134893.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|189914931, gi... - gi\|190149800\|ref\|YP_001968325.1\| dihydrolipoyllysine-residue succinyltransferase component of 2-oxog...	0.0	[1..398]	[1..407]
gi\|85713707, gi\|... - gi\|85713707\|ref\|ZP_01044697.1\| dihydrolipoamide acetyltransferase [Nitrobacter sp. Nb-311A], gi\|8569...	0.0	[3..398]	[2..426]
gi\|124115754, gi... - gi\|153213693\|ref\|ZP_01948945.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|229528898, gi... - gi\|229528898\|ref\|ZP_04418288.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229348922, gi... - gi\|229513741\|ref\|ZP_04403203.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|194535435, gi... - gi\|75823423\|ref\|ZP_00752925.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|254286797, gi... - gi\|254286797\|ref\|ZP_04961750.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... tr\|D7HAD6\|D7HAD6... - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... gi\|75819459, gi\|... - gi\|75819459\|ref\|ZP_00749538.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam...	0.0	[1..398]	[1..402]
gi\|227010100, gi... - gi\|227082212\|ref\|YP_002810763.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succin... gi\|229507825, gi... - gi\|229507825\|ref\|ZP_04397330.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|9656634, gi\|1... - gi\|9656634\|gb\|AAF95232.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltrans... gi\|229343763, gi... - gi\|229519074\|ref\|ZP_04408517.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat... gi\|229607370, gi... - gi\|229607370\|ref\|YP_002878018.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutara... gi\|75829400, gi\|... - gi\|75829400\|ref\|ZP_00758704.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|147675118, gi... - gi\|75827393\|ref\|ZP_00756828.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121727380, gi... - gi\|75814758\|ref\|ZP_00745311.1\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|121586902, gi... - gi\|121586902\|ref\|ZP_01676682.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|124119054, gi... - gi\|153222194\|ref\|ZP_01952973.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|153818382, gi... - gi\|153818382\|ref\|ZP_01971049.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|11257428 - pir\|\|A82121 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltransferase VC2086 ... gi\|229351903, gi... - gi\|229511938\|ref\|ZP_04401417.1\| dihydrolipoamide succinyltransferase component (E2) of 2-oxoglutarat...	0.0	[1..398]	[1..402]
gi\|90438940, gi\|... - gi\|90580055\|ref\|ZP_01235863.1\| dihydrolipoamide acetyltransferase [Vibrio angustum S14], gi\|90438940...	0.0	[1..398]	[1..399]
gi\|89073521, gi\|... - gi\|89073521\|ref\|ZP_01160044.1\| dihydrolipoamide acetyltransferase [Photobacterium sp. SKA34], gi\|890...	0.0	[1..398]	[1..399]
gi\|28805834 - gi\|28805834\|dbj\|BAC59111.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succinyltra... gi\|153838606, gi... - gi\|153838606\|ref\|ZP_01991273.1\| 2-oxoglutarate dehydrogenase, E2 component, dihydrolipoamide succiny... gi\|28805834, gi\|... - gi\|28897622\|ref\|NP_797227.1\| dihydrolipoamide acetyltransferase [Vibrio parahaemolyticus RIMD 221063...	0.0	[1..398]	[1..399]
gi\|91188013, gi\|... - gi\|91228429\|ref\|ZP_01262354.1\| dihydrolipoamide acetyltransferase [Vibrio alginolyticus 12G01], gi\|9...	0.0	[1..398]	[1..400]
gi\|53732513 - gi\|53732513\|ref\|ZP_00154561.2\| COG0508: Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoam... gi\|48868188, gi\|... - gi\|68250263\|ref\|YP_249375.1\| dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydr...	0.0	[1..398]	[1..407]
ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS... ODO2_HAEIN - Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex OS...	0.0	[1..398]	[1..407]

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Predicted Domain #1

Region A:
Residues: [1-170]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAVEVVMPKL GMAMKEGIIT SWNIKAGDNV AKGELIASIN SEKIETEIEA PADGTILDIA  60
   61 VSEDEGVPPG TVICYIGKPN EKVEVHESTK VEEELTASEV PQNVQHPEPL GKEVTNKQRI 120
  121 KISPVAKKIA KTENLDIRAL LGTGPGGRIT KVDVLKALEE RVAIPEVLEE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	24.522879
Match:	1zy8K
Description:	The crystal structure of dihydrolipoamide dehydrogenase and dihydrolipoamide dehydrogenase-binding protein (didomain) subcomplex of human pyruvate dehydrogenase complex.
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [171-398]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKVLPVTGMR KAIANRMHAS LQNSAQLTLT MKVDVTDLVA LHKEIAEVVQ KRYDNKLTIT  60
   61 DFVSRAVVLA LGEHKEMNSA YIDDAIHQFE HVHLGMAVAL EKGLVVPAIR FANNLSLVEL 120
  121 SKEIKNAAQK ARAGNLNSDD MQGTTFTISN LGSFGIEYFT PVLNTPETGI LGVGAIEHVP 180
  181 VYKGKKLKKG SMLPLSLTFD HRVLDGAPAA AFLRTIKRYL EEPVTILL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.09691
Match:	1c4tA
Description:	Dihydrolipoamide succinyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
S-succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue succinyltransferase activity	10.0778678835755	bayes_pls_golite062009
dihydrolipoyllysine-residue acetyltransferase activity	9.65061123545754	bayes_pls_golite062009
dihydrolipoamide S-acyltransferase activity	9.64995677986911	bayes_pls_golite062009
S-acetyltransferase activity	9.49696044977584	bayes_pls_golite062009
S-acyltransferase activity	8.45313874919036	bayes_pls_golite062009
pyruvate dehydrogenase activity	8.17557182322815	bayes_pls_golite062009
transferase activity, transferring acyl groups other than amino-acyl groups	6.86215901871647	bayes_pls_golite062009
acyltransferase activity	6.83977352892719	bayes_pls_golite062009
succinyltransferase activity	6.58826720904067	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	6.40483178382327	bayes_pls_golite062009
acetyltransferase activity	6.08159176722072	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	5.93985773477717	bayes_pls_golite062009
transferase activity, transferring acyl groups	4.60481199262496	bayes_pls_golite062009
alpha-ketoacid dehydrogenase activity	4.42757758312016	bayes_pls_golite062009
carnitine O-acyltransferase activity	2.87366177129153	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	2.54513901872655	bayes_pls_golite062009
catalytic activity	1.51562638409295	bayes_pls_golite062009
O-acyltransferase activity	1.33852311685118	bayes_pls_golite062009
O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
carnitine O-palmitoyltransferase activity	1.22729402619659	bayes_pls_golite062009
transferase activity	1.08341671157927	bayes_pls_golite062009
carnitine O-acetyltransferase activity	1.00868366840715	bayes_pls_golite062009
binding	0.801074244553007	bayes_pls_golite062009
O-acetyltransferase activity	0.54660034926676	bayes_pls_golite062009
protein binding	0.00454070917775817	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: