YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|49179508, gi\|...
Organism:	Bacillus anthracis str. Sterne
Length:	616 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|49179508, gi|....

Description	E-value	Query Range	Subject Range
gi\|30020887, gi\|... - gi\|30020887\|ref\|NP_832518.1\| sigma-54-dependent transcriptional activator [Bacillus cereus ATCC 1457... gi\|229128105, gi... - gi\|229128105\|ref\|ZP_04257087.1\| Sigma-54 dependent transcriptional regulator [Bacillus cereus BDRD-C...	0.0	[1..616]	[1..616]
gi\|42737775, gi\|... - gi\|42781851\|ref\|NP_979098.1\| acetoin operon transcriptional activator, putative [Bacillus cereus ATC...	0.0	[1..616]	[1..616]
gi\|52142748, gi\|... - gi\|52142748\|ref\|YP_084084.1\| sigma-54-dependent transcriptional activator [Bacillus cereus E33L], gi...	0.0	[1..616]	[1..616]
gi\|49329406, gi\|... - gi\|49477850\|ref\|YP_036856.1\| sigma-54-dependent transcriptional activator [Bacillus thuringiensis se...	0.0	[1..616]	[1..616]
gi\|89207390, gi\|... - gi\|89207390\|ref\|ZP_01185932.1\| Helix-turn-helix, Fis-type [Bacillus weihenstephanensis KBAB4], gi\|89...	0.0	[1..616]	[1..616]
gi\|25308291 - pir\|\|B83878 acetoin dehydrogenase operon transcription activator aciR [imported] - Bacillus halodura... gi\|15614389, gi\|... - gi\|15614389\|ref\|NP_242692.1\| transcriptional activator of the acetoin dehydrogenase operon [Bacillus...	0.0	[8..616]	[7..622]
gi\|472325, gi\|21... - gi\|472325\|gb\|AAA21743.1\| putative [Clostridium magnum], pir\|\|I40789 aco operon expression regulatory...	0.0	[1..616]	[1..643]
gi\|20515674, gi\|... - gi\|20807174\|ref\|NP_622345.1\| putative regulator of acetoin metabolism [Thermoanaerobacter tengcongen... gi\|20807174 - gi\|20807174\|ref\|NP_622345.1\| putative regulator of acetoin metabolism [Thermoanaerobacter tengcongen...	0.0	[5..616]	[10..652]
gi\|78044504, gi\|... - gi\|78044504\|ref\|YP_359642.1\| sigma-54 dependent transcriptional regulator [Carboxydothermus hydrogen...	4.0E-98	[7..616]	[1..611]
gi\|221312970 - gi\|221312970\|ref\|ZP_03594775.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. NC... ACOR_BACSU - Acetoin dehydrogenase operon transcriptional activator AcoR OS=Bacillus subtilis (strain 168) GN=aco... ACOR_BACSU - Acetoin dehydrogenase operon transcriptional activator AcoR OS=Bacillus subtilis GN=acoR PE=2 SV=1 gi\|221317896 - gi\|221317896\|ref\|ZP_03599190.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. JH... gi\|221322169 - gi\|221322169\|ref\|ZP_03603463.1\| transcriptional regulator [Bacillus subtilis subsp. subtilis str. SM...	3.0E-97	[1..616]	[1..601]

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Predicted Domain #1

Region A:
Residues: [1-156]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MLASPFYLHT WKKFVDEGVL DSNRINERIS ESWYRCKQAN VNPHMNKGQK ILSSNIFQDQ  60
   61 KKKSEIFLDI AIPQIQNMRK TIDELQMMAL LIDPDGYVLS LSGNEQTLKR AKHINFIEGV 120
  121 KWTEAAVGTN AIGTALEIEE AIMISGTEHY SVASHS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	12.39794
Match:	1jbkA
Description:	ClpB
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
hydrolase activity	1.18053993810305	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
purine ribonucleotide binding	0.0324692870996578	bayes_pls_golite062009
ribonucleotide binding	0.0319901144782286	bayes_pls_golite062009
purine nucleotide binding	0.0199205367873159	bayes_pls_golite062009
nucleotide binding	0.00540039127746217	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [157-547]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 WSCAAAPIHN DDGKLIGVLD FSCPIEFSHP YMLGMVTSIA HAIERECSIR VHQNELHLIH  60
   61 RFLDVIDSNE QVVICNHRNV IVSASKRIRE RVTNWSRMKL EDLMYYGLKT KLEVPVYSNN 120
  121 RMIGKCIYVK ENKQEKVFST SLFINGITFP GVIGTSDAFQ HTLEEIKLVS PTDASVYVCG 180
  181 ETGVGKEYVA RAIHENSPRK NGPFIAVNCG ALPKELMESE LFGYAEGAFT GARRQGYKGK 240
  241 FEQADGGTIF LDEIGEVPPE MQVALLRVLQ ERTVTPIGSS KEVPVNIRII TATHKDLLRL 300
  301 VEEGKFRQDL YYRLHVYPLY VPSLIERKED IPYFIKHFCK RKNWNVVFPK SICNQFSQHT 360
  361 WPGNIRELLN ALERIYILSQ GREICEKQIS F

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	62.045757
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
hydrolase activity	1.18053993810305	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
purine ribonucleotide binding	0.0324692870996578	bayes_pls_golite062009
ribonucleotide binding	0.0319901144782286	bayes_pls_golite062009
purine nucleotide binding	0.0199205367873159	bayes_pls_golite062009
nucleotide binding	0.00540039127746217	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [548-616]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LLQTMMRNQH QLELQTENKT EDTLNFREKI QRDSMIEALE KTNGNVSSAA KLLDVPRSTF  60
   61 YKRMQKYKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.39794
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: