YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|30254018, gi\|...
Organism:	Bacillus anthracis str. Ames
Length:	467 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|30254018, gi|....

Description	E-value	Query Range	Subject Range
gi\|89333754, gi\|... - gi\|89894306\|ref\|YP_517793.1\| hypothetical protein DSY1560 [Desulfitobacterium hafniense Y51], gi\|893... gi\|219538975, gi... - gi\|68207534\|ref\|ZP_00559693.1\| PAS:Helix-turn-helix, Fis-type [Desulfitobacterium hafniense DCB-2], ...	3.0E-92	[1..466]	[132..596]
gi\|89210675, gi\|... - gi\|89210675\|ref\|ZP_01189062.1\| PAS:Helix-turn-helix, Fis-type [Halothermothrix orenii H 168], gi\|891...	8.0E-92	[1..466]	[118..581]
gi\|222054817, gi... - gi\|222054817\|ref\|YP_002537179.1\| two component, sigma54 specific, transcriptional regulator, Fis fam...	1.0E-91	[2..467]	[13..477]
gi\|77545639, gi\|... - gi\|77919556\|ref\|YP_357371.1\| response regulator transcription factor [Pelobacter carbinolicus DSM 23...	2.0E-91	[5..465]	[28..471]
gi\|115377076, gi... - gi\|115377076\|ref\|ZP_01464292.1\| two component, sigma54 specific, transcriptional regulator, Fis fami...	5.0E-91	[11..466]	[1..440]
gi\|134052275, gi... - gi\|88944838\|ref\|ZP_01148061.1\| PAS:Helix-turn-helix, Fis-type [Desulfotomaculum reducens MI-1], gi\|8...	2.0E-90	[12..465]	[127..578]
gi\|20808135 - gi\|20808135\|ref\|NP_623306.1\| NtrC family Transcriptional regulator, ATPase domain [Thermoanaerobacte... gi\|20808135, gi\|... - gi\|20808135\|ref\|NP_623306.1\| transcriptional regulator [Thermoanaerobacter tengcongensis MB4], gi\|20...	2.0E-90	[19..465]	[168..607]
gi\|46581622, gi\|... - gi\|46581622\|ref\|YP_012430.1\| sigma-54 dependent transcriptional regulator/response regulator [Desulf... gi\|241908558, gi... - gi\|241908558\|ref\|ZP_04793124.1\| two component, sigma54 specific, transcriptional regulator, Fis fami...	2.0E-90	[7..465]	[19..456]
gi\|146398219, gi... - gi\|88934576\|ref\|ZP_01140218.1\| Helix-turn-helix, Fis-type [Geobacter uraniumreducens Rf4], gi\|889187...	2.0E-90	[2..466]	[12..455]
gi\|51978287, gi\|... - gi\|52144818\|ref\|YP_082012.1\| arginine utilization regulatory protein [Bacillus cereus E33L], gi\|5197...	2.0E-90	[1..467]	[1..467]

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Predicted Domain #1

Region A:
Residues: [1-389]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MRTEEINLKQ IIEMNMLYET LLNELDIGIH IINEESKTII YNRKMMEIES MERSDVLYKS  60
   61 PLEVFAFEEN KNSTLIEALK LGKTNKNIKQ TYFNNKGQEI TTINDTFPII ENGKIKGAIE 120
  121 ISKEMNHLKQ TIKMDSFRKQ NTKFTFDHII GDSEAIQSTI AEGKRVIRTS SSILLVGETG 180
  181 TGKELFAQSI HNESQRSTKP FISQNCAAIP DTLMESLLFG TNRGAFTGAI DKAGLFEEAN 240
  241 GGTLLLDEIN SLSPALQAKL LRAIQEKTIR RIGGTQEKEI DVRIIATINE DPLEAITHNR 300
  301 LREDLYYRLS VVTLCLPPLR ERKEDIPALV QHFIEKYNIQ FGLSVTDVDI HVREFLYAYD 360
  361 WPGNVRELEH IIEGSMNLVE DENIITAFH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	72.522879
Match:	1ny5A
Description:	Crystal structure of sigm54 activator (AAA+ ATPase) in the inactive state
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein histidine kinase activity	2.35011582062573	bayes_pls_golite062009
two-component sensor activity	2.32303301074957	bayes_pls_golite062009
phosphotransferase activity, nitrogenous group as acceptor	2.28838869071567	bayes_pls_golite062009
two-component response regulator activity	1.45919623810582	bayes_pls_golite062009
catalytic activity	1.37148167194523	bayes_pls_golite062009
binding	1.30574971150356	bayes_pls_golite062009
hydrolase activity	1.18053993810305	bayes_pls_golite062009
nucleic acid binding	0.900561861643259	bayes_pls_golite062009
transcription regulator activity	0.530058973650498	bayes_pls_golite062009
DNA binding	0.460315660888175	bayes_pls_golite062009
purine ribonucleotide binding	0.0324692870996578	bayes_pls_golite062009
ribonucleotide binding	0.0319901144782286	bayes_pls_golite062009
purine nucleotide binding	0.0199205367873159	bayes_pls_golite062009
nucleotide binding	0.00540039127746217	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [390-467]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LPTRFREQIK KEFNTQPFLT NNATDAPKTL KHTIAEMEKN YITQILKEYH GNISQAAKFL  60
   61 GLSRQNLQYR IKKLHLHI

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	74.154902
Match:	1ojlA
Description:	Crystal structure of a sigma54-activator suggests the mechanism for the conformational switch necessary for sigma54 binding
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: