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View Structure Prediction Details

Protein: gi|46579147, gi|...
Organism: Desulfovibrio vulgaris str. Hildenborough
Length: 503 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|46579147, gi|....

Description E-value Query
Range
Subject
Range
gi|23473894, gi|... - gi|78357878|ref|YP_389327.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...
0.0 [1..500] [1..500]
gi|88945102, gi|... - gi|88945102|ref|ZP_01148322.1| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfotomaculum re...
0.0 [1..499] [3..505]
gi|71489436, gi|... - gi|71544542|ref|ZP_00665566.1| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophobacter fum...
0.0 [2..499] [5..502]
gi|48845542, gi|... - gi|78224426|ref|YP_386173.1| uroporphyrinogen-III synthase / uroporphyrinogen-III C-methyltransferas...
0.0 [3..499] [11..508]
gi|51245586, gi|... - gi|51245586|ref|YP_065470.1| uroporphyrinogen III synthase/methyltransferase (HemD+CobA) [Desulfotal...
0.0 [2..500] [12..515]
gi|94730811, gi|... - gi|94986562|ref|YP_594495.1| siroheme synthase [Lawsonia intracellularis PHE/MN1-00], gi|94730811|em...
0.0 [1..501] [1..502]
gi|109645297, gi... - gi|68208394|ref|ZP_00560513.1| Uroporphyrin-III C-methyltransferase, C-terminal [Desulfitobacterium ...
0.0 [3..498] [6..500]
gi|12655814 - gi|12655814|gb|AAK00606.1|AF221100_3 uroporphyrinogen III synthase/methyltransferase [Selenomonas ru...
0.0 [3..498] [8..505]
gi|85858419, gi|... - gi|85858419|ref|YP_460621.1| uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase [S...
0.0 [2..502] [13..512]
gi|114337164, gi... - gi|71542778|ref|ZP_00664324.1| Uroporphyrin-III C-methyltransferase, C-terminal [Syntrophomonas wolf...
0.0 [3..500] [7..505]

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Predicted Domain #1
Region A:
Residues: [1-253]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKVYLIGAGP GDPGLLTLKG KEILERADVV VYDFLANDAF LAYAKPDAEI IYVGKKGGDH  60
   61 TLSQDGINRL IIEKAKEGKV VARLKGGDPY MFGRGGEEAE ELLDAGVPFE EVPGVTSAIA 120
  121 GPAYAGIPLT HRSYASSVSF ITGHENPDKP DSAHNWQALA AGTSTLVFFM GMKNLPDISR 180
  181 KLIAAGMSPD KPAALVRWGT TPRHRSLVAT IATLPEEAVK HGFSNPSLIV VGDVVRLRDR 240
  241 LNWFEHKPLL GKG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 62.0
Match: 1pjqA
Description: Structure and function of CysG, the multifunctional methyltransferase/dehydrogenase/ferrochelatase for siroheme synthesis
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uroporphyrin-III C-methyltransferase activity 3.573271502205 bayes_pls_golite062009
C-methyltransferase activity 3.35393353163232 bayes_pls_golite062009
precorrin-4 C11-methyltransferase activity 2.18371138649366 bayes_pls_golite062009
catalytic activity 1.48349578618275 bayes_pls_golite062009
transferase activity 0.912524944496351 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 0.431791521097299 bayes_pls_golite062009
methyltransferase activity 0.424918406685891 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 0.28351517300952 bayes_pls_golite062009
uroporphyrinogen-III synthase activity 0.00871858903098705 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [254-503]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VVVTRAREQA SGLAAALREL GADVIQFPTI DIHPLDDYAP VHEAIRALDT YDWVVFTSVN  60
   61 GVKHFWNQLA ALGLDSRALG GRKVAAIGPA TADALRDKGI APDFIPEKYV AEGVVEGMLA 120
  121 RGMGGKRVLL PRALEAREVL PEELRKAGAT VDVLPVYVTV PSAARRDDVL ARMEAGEVHC 180
  181 VTFGSSSTVE NFFSLVPADT VKAHPEVKLA CIGPVTKKTL EGFGFTCHIQ PDDYTIPALV 240
  241 DELTRVLPEL 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 41.0
Match: 1jr2A
Description: Uroporphyrinogen III synthase (U3S, HemD)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
uroporphyrinogen-III synthase activity 3.34629127241283 bayes_pls_golite062009
catalytic activity 1.13824203225664 bayes_pls_golite062009
lyase activity 0.352588988142348 bayes_pls_golite062009
hydro-lyase activity 0.290711782955013 bayes_pls_golite062009
carbon-oxygen lyase activity 0.212880565996123 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle