YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|29541726, gi\|...
Organism:	Coxiella burnetii RSA 493
Length:	257 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|29541726, gi|....

Description	E-value	Query Range	Subject Range
gi\|775152 - gi\|775152\|gb\|AAA65156.1\| anthranilate isomerase	215.0	[0..1]	[257..1]
gi\|218365016, gi... - gi\|218558247\|ref\|YP_002391160.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylant... gi\|117623523, gi... - gi\|117623523\|ref\|YP_852436.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthra... gi\|237705286, gi... - gi\|237705286\|ref\|ZP_04535767.1\| anthranilate isomerase [Escherichia sp. 3_2_53FAA], gi\|226900043\|gb\|... gi\|91072128, gi\|... - gi\|91210554\|ref\|YP_540540.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	214.0	[0..1]	[257..1]
TRPC_ECO57 - Tryptophan biosynthesis protein TrpCF OS=Escherichia coli O157:H7 GN=trpC PE=3 SV=2 gi\|189406146, gi... - gi\|189406146\|ref\|ZP_02826616.2\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|208816244, gi... - gi\|208816244\|ref\|ZP_03257423.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|254592251, gi... - gi\|254792851\|ref\|YP_003077688.1\| N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolpho... gi\|209395881, gi... - gi\|209395881\|ref\|YP_002270317.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str... gi\|187769285, gi... - gi\|187776053\|ref\|ZP_02800078.2\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|189402573, gi... - gi\|189402573\|ref\|ZP_02783354.2\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|189366261, gi... - gi\|189404336\|ref\|ZP_02788597.2\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str....	214.0	[0..1]	[257..1]
gi\|168771261, gi... - gi\|189359978\|gb\|EDU78397.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str. EC4... gi\|168783765, gi... - gi\|188998926\|gb\|EDU67912.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str. EC4... gi\|195939196 - gi\|195939196\|ref\|ZP_03084578.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanth... gi\|208724351, gi... - gi\|208810845\|ref\|ZP_03252678.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|168751151, gi... - gi\|188014752\|gb\|EDU52874.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str. EC4... TRPC_ECO57 - Tryptophan biosynthesis protein TrpCF OS=Escherichia coli O157:H7 GN=trpC PE=3 SV=3 gi\|209772084, gi... - pir\|\|F85761 hypothetical protein trpC [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|13361299, gi\|... - gi\|15831088\|ref\|NP_309861.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran... gi\|208818817, gi... - gi\|208818817\|ref\|ZP_03259137.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str.... gi\|15801916, gi\|... - gi\|15801916\|ref\|NP_287937.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran... gi\|217317664, gi... - gi\|217329225\|ref\|ZP_03445305.1\| tryptophan biosynthesis protein trpCF [Escherichia coli O157:H7 str....	213.0	[0..1]	[257..2]
gi\|74312368, gi\|... - gi\|74312368\|ref\|YP_310787.1\| bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthran...	213.0	[0..1]	[257..2]
gi\|75235230 - gi\|75235230\|ref\|ZP_00719467.1\| COG0134: Indole-3-glycerol phosphate synthase [Escherichia coli E1100...	213.0	[0..1]	[257..2]

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Predicted Domain #1

Region A:
Residues: [1-257]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MHDYLKAILK NKKQEIAHLK ANFSSDAFSL STKKSFKRII SSTPTTIIAE IKRRSPSKGH  60
   61 LAEIADPVAL AKQYVQGGAA GVSVLTDKLA FDGSIRDLQQ VSLELRDRPV AVLRKDFILD 120
  121 PLQIEEAAVA GADAILLIVA ILKDATKILL QKAHECGLEA LVEVHNRQEL DQAIEIGAEI 180
  181 IGVNNRNLTT FSVDPNNALK LKPYIPDHII SVAESGIHTV SDAKRYISAG YNAVLVGEAL 240
  241 VKSENPQQFI SAIKEND

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.0
Match:	1piiA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	3.15663465352598	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	3.12120866545322	bayes_pls_golite062009
catalytic activity	2.81275055404078	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.655130814615	bayes_pls_golite062009
carbon-carbon lyase activity	2.44001937916931	bayes_pls_golite062009
carboxy-lyase activity	1.80978905789979	bayes_pls_golite062009
lyase activity	0.9228652996943	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.82314869965119	bayes_pls_golite062009
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	0.302746738903759	bayes_pls_golite062009
isomerase activity	0.14149405165663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: