YRC Public Data Repository - Protein Structure Prediction

Protein:	PYRF_COXBU
Organism:	Coxiella burnetii RSA 493
Length:	236 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PYRF_COXBU.

Description	E-value	Query Range	Subject Range
gi\|116187749, gi... - gi\|75828740\|ref\|ZP_00758086.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Vibrio cholerae MO10],... gi\|229351734, gi... - gi\|229511769\|ref\|ZP_04401248.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae B33], gi\|22935... gi\|121630524, gi... - gi\|75816131\|ref\|ZP_00746610.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Vibrio cholerae V52], ... PYRF_VIBCM - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain M66-2) GN=pyrF PE=3 SV=1 gi\|229507993, gi... - gi\|229507993\|ref\|ZP_04397498.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae BX 330286], gi... gi\|229518907, gi... - gi\|229518907\|ref\|ZP_04408350.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae RC9], gi\|22934... gi\|229607539, gi... - gi\|229607539\|ref\|YP_002878187.1\| orotidine 5'-phosphate decarboxylase [Vibrio cholerae MJ-1236], gi\|... PYRF_VIBCH - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inab... PYRF_VIBCH - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae GN=pyrF PE=1 SV=1 gi\|121546724, gi... - gi\|121591429\|ref\|ZP_01678708.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae 2740-80], gi\|1... gi\|153225057, gi... - gi\|153225057\|ref\|ZP_01954684.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae MAK 757], gi\|1... gi\|153819859, gi... - gi\|153819859\|ref\|ZP_01972526.1\| orotidine 5`-phosphate decarboxylase [Vibrio cholerae NCTC 8457], gi...	235.0	[0..4]	[233..2]
PYRF_VIBC3 - Orotidine 5'-phosphate decarboxylase OS=Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical O...	235.0	[0..4]	[233..2]
gi\|69156212, gi\|... - gi\|91793113\|ref\|YP_562764.1\| orotidine 5'-phosphate decarboxylase [Shewanella denitrificans OS217], ...	233.0	[0..7]	[233..5]
PYRF_PASMU - Orotidine 5'-phosphate decarboxylase OS=Pasteurella multocida GN=pyrF PE=3 SV=1 PYRF_PASMU - Orotidine 5'-phosphate decarboxylase OS=Pasteurella multocida (strain Pm70) GN=pyrF PE=3 SV=1	233.0	[0..1]	[233..1]
gi\|238794724, gi... - gi\|77977460\|ref\|ZP_00832908.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Yersinia intermedia AT...	233.0	[0..6]	[233..15]
gi\|53728748 - gi\|53728748\|ref\|ZP_00135484.2\| COG0284: Orotidine-5'-phosphate decarboxylase [Actinobacillus pleurop... PYRF_ACTPJ - Orotidine 5'-phosphate decarboxylase OS=Actinobacillus pleuropneumoniae serotype 3 (strain JL03) GN=... PYRF_ACTP2 - Orotidine 5'-phosphate decarboxylase OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) GN=... PYRF_ACTP7 - Orotidine 5'-phosphate decarboxylase OS=Actinobacillus pleuropneumoniae serotype 7 (strain AP76) GN=...	232.0	[0..1]	[234..1]
PYRF_HAEIN - Orotidine 5'-phosphate decarboxylase OS=Haemophilus influenzae GN=pyrF PE=3 SV=1 gi\|46133576 - gi\|46133576\|ref\|ZP_00157409.2\| COG0284: Orotidine-5'-phosphate decarboxylase [Haemophilus influenzae... PYRF_HAEIN - Orotidine 5'-phosphate decarboxylase OS=Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20... gi\|145274277, gi... - gi\|145641116\|ref\|ZP_01796697.1\| orotidine 5'-phosphate decarboxylase [Haemophilus influenzae R3021],... gi\|145641116 - gi\|145641116\|ref\|ZP_01796697.1\| orotidine 5'-phosphate decarboxylase [Haemophilus influenzae R3021] gi\|145639205, gi... - gi\|145639205\|ref\|ZP_01794812.1\| orotidine 5'-phosphate decarboxylase [Haemophilus influenzae PittII]...	232.0	[0..1]	[233..1]
PYRF_VIBPA - Orotidine 5'-phosphate decarboxylase OS=Vibrio parahaemolyticus GN=pyrF PE=3 SV=1 PYRF_VIBPA - Orotidine 5'-phosphate decarboxylase OS=Vibrio parahaemolyticus serotype O3:K6 (strain RIMD 2210633)...	232.0	[0..7]	[236..5]
PYRF_HAEIE - Orotidine 5'-phosphate decarboxylase OS=Haemophilus influenzae (strain PittEE) GN=pyrF PE=3 SV=1 gi\|145636914, gi... - gi\|145636914\|ref\|ZP_01792579.1\| orotidine 5'-phosphate decarboxylase [Haemophilus influenzae PittHH]... gi\|53732728 - gi\|53732728\|ref\|ZP_00154980.2\| COG0284: Orotidine-5'-phosphate decarboxylase [Haemophilus influenzae...	231.0	[0..1]	[233..1]
gi\|77960384 - gi\|77960384\|ref\|ZP_00824258.1\| COG0284: Orotidine-5'-phosphate decarboxylase [Yersinia mollaretii AT...	230.0	[0..6]	[235..15]

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Predicted Domain #1

Region A:
Residues: [1-236]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKPDPKVIV AIDAGTVEQA RAQINPLTPE LCHLKIGSIL FTRYGPAFVE ELMQKGYRIF  60
   61 LDLKFYDIPQ TVAGACRAVA ELGVWMMNIH ISGGRTMMET VVNALQSITL KEKPLLIGVT 120
  121 ILTSLDGSDL KTLGIQEKVP DIVCRMATLA KSAGLDGVVC SAQEAALLRK QFDRNFLLVT 180
  181 PGIRLETDEK GDQKRVMTPR AAIQAGSDYL VIGRPITQST DPLKALEAID KDIKTR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	58.30103
Match:	1eixA
Description:	Orotidine 5'-monophosphate decarboxylase (OMP decarboxylase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
orotidine-5'-phosphate decarboxylase activity	2.87717797280068	bayes_pls_golite062009
catalytic activity	2.44231061702877	bayes_pls_golite062009
ribulose-phosphate 3-epimerase activity	0.982517927791965	bayes_pls_golite062009
carboxy-lyase activity	0.83446736141993	bayes_pls_golite062009
orotate phosphoribosyltransferase activity	0.108467338662618	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: