YRC Public Data Repository - Protein Structure Prediction

Protein:	SYA_SHEON
Organism:	Shewanella oneidensis MR-1
Length:	874 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYA_SHEON.

Description	E-value	Query Range	Subject Range
gi\|75241640, gi\|... - gi\|75241640\|ref\|ZP_00725477.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli F11], gi\|191171366\|...	1243.0	[0..1]	[873..1]
gi\|227888232, gi... - gi\|227888232\|ref\|ZP_04006037.1\| alanyl-tRNA synthetase [Escherichia coli 83972], gi\|227834501\|gb\|EEJ... SYA_ECOHS - Alanine--tRNA ligase OS=Escherichia coli O9:H4 (strain HS) GN=alaS PE=3 SV=1 gi\|218428383, gi... - gi\|218690819\|ref\|YP_002399031.1\| alanyl-tRNA synthetase [Escherichia coli ED1a], gi\|218428383\|emb\|CA...	1230.0	[0..1]	[873..1]
gi\|75512393, gi\|... - gi\|75512393\|ref\|ZP_00734945.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli 53638], gi\|18849203... gi\|238901834, gi... - gi\|238901834\|ref\|YP_002927630.1\| alanyl-tRNA synthetase [Escherichia coli BW2952], gi\|238859951\|gb\|A... SYA_ECODH - Alanine--tRNA ligase OS=Escherichia coli (strain K12 / DH10B) GN=alaS PE=3 SV=1 SYA_ECOLI - Alanyl-tRNA synthetase (EC 6.1.1.7) (Alanine--tRNA ligase) (AlaRS) - Escherichia coli gi\|1800083, gi\|8... - gi\|89109484\|ref\|AP_003264.1\| alanyl-tRNA synthetase [Escherichia coli str. K-12 substr. W3110], gi\|1... EG10034 - alanyl-tRNA synthetase / Alanine--tRNA ligase, autorepressor gi\|194422121, gi... - gi\|83585644\|ref\|ZP_00924287.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli 101-1], gi\|19443900... gi\|226839360, gi... - gi\|254037736\|ref\|ZP_04871794.1\| alanyl t-RNA synthetase [Escherichia sp. 1_1_43], gi\|226839360\|gb\|EE... EG10034 - alanyl-tRNA synthetase / Alanine--tRNA ligase, autorepressor	1230.0	[0..1]	[873..1]
SYA_SHISS - Alanine--tRNA ligase OS=Shigella sonnei (strain Ss046) GN=alaS PE=3 SV=1 gi\|209920136, gi... - gi\|209920136\|ref\|YP_002294220.1\| alanyl-tRNA synthetase [Escherichia coli SE11], gi\|209913395\|dbj\|BA... gi\|75256897, gi\|... - gi\|75256897\|ref\|ZP_00728473.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli E22], gi\|193065058\|... gi\|193069650, gi... - gi\|75235710\|ref\|ZP_00719884.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli E110019], gi\|193069... gi\|218555239, gi... - gi\|218555239\|ref\|YP_002388152.1\| alanyl-tRNA synthetase [Escherichia coli IAI1], gi\|218362007\|emb\|CA... gi\|218353020, gi... - gi\|218696288\|ref\|YP_002403955.1\| alanyl-tRNA synthetase [Escherichia coli 55989], gi\|218353020\|emb\|C... gi\|75229772, gi\|... - gi\|75229772\|ref\|ZP_00716302.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli B7A], gi\|191167095\|... gi\|194427866, gi... - gi\|75210896\|ref\|ZP_00711020.1\| COG0013: Alanyl-tRNA synthetase [Escherichia coli B171], gi\|194427866... SYA_ECO24 - Alanine--tRNA ligase OS=Escherichia coli O139:H28 (strain E24377A / ETEC) GN=alaS PE=3 SV=1	1230.0	[0..1]	[873..1]
SYA_ECOL5 - Alanine--tRNA ligase OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=alaS PE=3 SV=1	1230.0	[0..1]	[873..1]
gi\|218366454, gi... - gi\|218559685\|ref\|YP_002392598.1\| alanyl-tRNA synthetase [Escherichia coli S88], gi\|218366454\|emb\|CAR... SYA_ECOK1 - Alanine--tRNA ligase OS=Escherichia coli O1:K1 / APEC GN=alaS PE=3 SV=1 gi\|237706683, gi... - gi\|237706683\|ref\|ZP_04537164.1\| alanyl-tRNA synthetase [Escherichia sp. 3_2_53FAA], gi\|226899723\|gb\|... SYA_ECOUT - Alanine--tRNA ligase OS=Escherichia coli (strain UTI89 / UPEC) GN=alaS PE=3 SV=1	1229.0	[0..1]	[873..1]
SYA_SHIDS - Alanine--tRNA ligase OS=Shigella dysenteriae serotype 1 (strain Sd197) GN=alaS PE=3 SV=1	1229.0	[0..1]	[873..1]
gi\|56480163, gi\|... - gi\|56480163\|ref\|NP_708505.2\| alanyl-tRNA synthetase [Shigella flexneri 2a str. 301], gi\|56383714\|gb\|... SYA_SHIF8 - Alanine--tRNA ligase OS=Shigella flexneri serotype 5b (strain 8401) GN=alaS PE=3 SV=1 SYA_SHIFL - Alanine--tRNA ligase OS=Shigella flexneri GN=alaS PE=3 SV=1 gi\|30064057, gi\|... - gi\|30064057\|ref\|NP_838228.1\| alanyl-tRNA synthetase [Shigella flexneri 2a str. 2457T], gi\|30042313\|g...	1228.0	[0..1]	[873..1]
gi\|15832808, gi\|... - gi\|15832808\|ref\|NP_311581.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. Sakai], gi\|133630... gi\|168774775, gi... - gi\|187769613\|gb\|EDU33457.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4196], gi\|168774... gi\|189003197, gi... - gi\|189003197\|gb\|EDU72183.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4076], gi\|168778... gi\|189377449, gi... - gi\|189377449\|gb\|EDU95865.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC508], gi\|1688002... gi\|25293071 - pir\|\|B91073 alanyl-tRNA synthetase [imported] - Escherichia coli (strain O157:H7, substrain RIMD 050... gi\|195938445 - gi\|195938445\|ref\|ZP_03083827.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4024] gi\|208805868, gi... - gi\|208805868\|ref\|ZP_03248205.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4206], gi\|20... gi\|208735038, gi... - gi\|208813761\|ref\|ZP_03255090.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4045], gi\|20... gi\|208738409, gi... - gi\|208818286\|ref\|ZP_03258606.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4042], gi\|20... gi\|209160191, gi... - gi\|209398791\|ref\|YP_002272160.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4115], gi\|2... gi\|168749982, gi... - gi\|188015823\|gb\|EDU53945.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4113], gi\|168749... gi\|189357241, gi... - gi\|189357241\|gb\|EDU75660.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4401], gi\|168755... gi\|189366853, gi... - gi\|189366853\|gb\|EDU85269.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4501], gi\|168762... SYA_ECO57 - Alanine--tRNA ligase OS=Escherichia coli O157:H7 GN=alaS PE=3 SV=2 gi\|189362083, gi... - gi\|189362083\|gb\|EDU80502.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. EC4486], gi\|168768... gi\|83569947, gi\|... - gi\|83569947\|ref\|ZP_00921395.1\| COG0013: Alanyl-tRNA synthetase [Shigella dysenteriae 1012], gi\|19443... gi\|217327497, gi... - gi\|217327497\|ref\|ZP_03443580.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14588], gi\|2... gi\|254594038, gi... - gi\|254794638\|ref\|YP_003079475.1\| alanyl-tRNA synthetase [Escherichia coli O157:H7 str. TW14359], gi\|...	1228.0	[0..1]	[873..1]
SYA_SHIBS - Alanine--tRNA ligase OS=Shigella boydii serotype 4 (strain Sb227) GN=alaS PE=3 SV=1	1228.0	[0..1]	[873..1]

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Predicted Domain #1

Region A:
Residues: [1-463]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MYQTTAALRS AFLEFFRSNG HQVVDSSSLV PGNDPTLLFT NAGMNQFKDV FLGMDKRSYT  60
   61 RATTAQRCVR AGGKHNDLDN VGYTARHHTF FEMLGNFSFG DYFKEDAIRF GWTFLTEVLM 120
  121 LPKERLCVTI YQTDDEAFEI WNKKIGVAAE NIIRIGDNKG APYASDNFWQ MGDTGPCGPC 180
  181 TEIFYDHGDH IWGGRPGSPE EDGDRFIEIW NIVFMQYNRQ ASGEMLPLPK PSVDTGMGIE 240
  241 RIAAIMQGVH SNYEIDIFRA LIAKAAEIIG VADLSNKSLR VIADHIRSCA FLVADGVMPS 300
  301 NEGRGYVLRR IIRRAVRHGN KLGATEAFFY KLVPTLIDVM GDAAKGLAET QVIVEKALKA 360
  361 EEEQFARTLE RGLGILDSAL NELQGDTLDG ETVFKLYDTY GFPVDLTADV CRERNIIVDE 420
  421 AGFEAAMAEQ RSRAQAAGNF GADYNAALKI DAETAFCGYS ELT

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1000.0
Match:	1riqA
Description:	The crystal structure of the catalytic fragment of the alanyl-tRNA synthetase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
alanine-tRNA ligase activity	6.00693881794242	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	2.76416144738864	bayes_pls_golite062009
threonine-tRNA ligase activity	2.18642354927	bayes_pls_golite062009
glycine-tRNA ligase activity	2.17047432052132	bayes_pls_golite062009
serine-tRNA ligase activity	2.07594942154162	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
transcription regulator activity	1.03781135697387	bayes_pls_golite062009
nucleic acid binding	1.0144617399226	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
binding	0.904147650999471	bayes_pls_golite062009
DNA binding	0.8162402823536	bayes_pls_golite062009
transcription repressor activity	0.433976751263	bayes_pls_golite062009
transcription factor activity	0.140257788851398	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [464-745]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GNAKVTALYL NGESVPAINT GDDAVVVLDV TPFYAESGGQ VGDKGVLMAQ GIEFTVNDTQ  60
   61 KFGQASGHKG TLTAGSLSVG QVLEAKVDKK LRHRTQLNHS VTHLLHAALR QVLGTHVTQK 120
  121 GSLVDPERLR FDFSHFEAVK PFELKQVEEL VNTQIRRNHE LKVAEMAIDE AKEKGAMALF 180
  181 GEKYDSQVRV VTMGDFSIEL CGGTHVGRTG DIGLFKITSE GGIAAGVRRI EAVTGAAAMA 240
  241 YVAQQQAELE EAASLLKADA HSVVTKLKVQ LDKMKQLEKE MQ

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.09691
Match:	1nyqA
Description:	Structure of Staphylococcus aureus threonyl-tRNA synthetase complexed with an analogue of threonyl adenylate
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [746-874]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QLKDKLAAAA SADLAGDAVV VNGVNVLIKK LEGVEAGALR GLQDELKQKL KSAIIVLGVA  60
   61 QEGKVNLIAG VSNDLIAKIK AGELVAMVAT QVGGKGGGRP DMAQAGGSQP ENLDAALSQV 120
  121 LPWITERLA

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	18.853872
Match:	PF02272.10
Description:	No description for PF02272.10 was found.

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.743	0.156	ATP binding	d.58.17	Metal-binding domain
View	Download	0.756	0.006	aminoacyl-tRNA ligase activity	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.762	0.004	aminoacyl-tRNA ligase activity	d.58.10	Acylphosphatase-like
View	Download	0.753	N/A	N/A	d.58.18	Regulatory domain in the aminoacid metabolism
View	Download	0.736	N/A	N/A	d.58.17	Metal-binding domain

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: