YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|24051146, gi\|...
Organism:	Shigella flexneri 2a str. 301
Length:	135 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|24051146, gi|....

Description	E-value	Query Range	Subject Range
gi\|254792733, gi... - gi\|254792733\|ref\|YP_003077570.1\| DicA-like protein, regulator of DicB [Escherichia coli O157:H7 str.... gi\|218431640, gi... - gi\|218704543\|ref\|YP_002412062.1\| transcriptional repressor DicA [Escherichia coli UMN026], gi\|218431... gi\|25301360, gi\|... - pir\|\|D85707 probable regulatory protein [imported] - Escherichia coli (strain O157:H7, substrain ED... gi\|218351187, gi... - gi\|218694455\|ref\|YP_002402122.1\| transcriptional repressor DicA [Escherichia coli 55989], gi\|2183511... gi\|15831019, gi\|... - gi\|15831019\|ref\|NP_309792.1\| transcriptional repressor DicA [Escherichia coli O157:H7 str. Sakai], g... gi\|208814889, gi... - gi\|208814889\|ref\|ZP_03256068.1\| HTH-type transcriptional regulator DicA [Escherichia coli O157:H7 st... gi\|12514990, gi\|... - gi\|15801491\|ref\|NP_287508.1\| transcriptional repressor DicA [Escherichia coli O157:H7 EDL933], gi\|12... gi\|15831019, gi\|... - gi\|15831019\|ref\|NP_309792.1\| putative regulatory protein [Escherichia coli O157:H7], gi\|13361230\|dbj...	110.0	[0..1]	[135..1]
gi\|75254944 - gi\|75254944\|ref\|ZP_00726893.1\| COG1396: Predicted transcriptional regulators [Escherichia coli E22]	98.0	[0..13]	[135..2]
gi\|19745754, gi\|... - gi\|19747895\|gb\|AAL97389.1\| putative repressor protein [Streptococcus pyogenes MGAS8232], gi\|19745754... gi\|139474145, gi... - gi\|139474145\|ref\|YP_001128861.1\| putative phage repressor protein [Streptococcus pyogenes str. Manfr...	97.0	[0..1]	[131..1]
gi\|91191378, gi\|... - gi\|91223886\|ref\|ZP_01259150.1\| putative transcriptional regulator [Vibrio alginolyticus 12G01], gi\|9...	95.0	[0..1]	[131..1]
DICA_ECOLI - HTH-type transcriptional regulator dicA (Repressor protein of division inhibition gene dicA) - Esche... EG10226 - Qin prophage; putative regulator for DicB / Transcriptional repressor for dicB, Qin prophage gi\|218360904, gi... - gi\|218554136\|ref\|YP_002387049.1\| transcriptional repressor DicA [Escherichia coli IAI1], gi\|21836090... gi\|169889072, gi... - gi\|170081237\|ref\|YP_001730557.1\| Qin prophage; regulator for DicB [Escherichia coli str. K-12 substr... gi\|169755003, gi... - gi\|170020075\|ref\|YP_001725029.1\| transcriptional repressor DicA [Escherichia coli ATCC 8739], gi\|169... gi\|238863388, gi... - gi\|238900790\|ref\|YP_002926586.1\| Qin prophage; putative regulator for DicB [Escherichia coli BW2952]... EG10226 - Qin prophage; putative regulator for DicB / Transcriptional repressor for dicB, Qin prophage gi\|89108412, gi\|... - gi\|89108412\|ref\|AP_002192.1\| predicted regulator for DicB [Escherichia coli str. K-12 substr. W3110]...	95.0	[0..2]	[135..4]
gi\|28806770 - gi\|28806770\|dbj\|BAC60041.1\| putative transcriptional regulator [Vibrio parahaemolyticus RIMD 2210633... gi\|28898552, gi\|... - gi\|28898552\|ref\|NP_798157.1\| DNA-binding transcriptional repressor PuuR [Vibrio parahaemolyticus RIM... gi\|153836272, gi... - gi\|153836272\|ref\|ZP_01988939.1\| HTH-type transcriptional regulator PuuR [Vibrio parahaemolyticus AQ3...	94.0	[0..1]	[131..1]
gi\|94994722, gi\|... - gi\|94994722\|ref\|YP_602820.1\| Transcriptional regulator, Cro/CI family [Streptococcus phage 10750.3],...	92.0	[0..3]	[133..21]
gi\|48835840 - ref\|ZP_00292838.1\| COG3800: Predicted transcriptional regulator [Thermobifida fusca] gi\|72161782, gi\|... - gi\|72161782\|ref\|YP_289439.1\| helix-hairpin-helix DNA-binding motif-containing protein [Thermobifida ...	92.0	[0..5]	[133..12]
gi\|13622576, gi\|... - gi\|15675391\|ref\|NP_269565.1\| putative repressor - phage associated [Streptococcus phage 370.2], gi\|1... gi\|21910679, gi\|... - gi\|21910679\|ref\|NP_664947.1\| putative cI-like repressor - phage associated [Streptococcus pyogenes M... gi\|28810880, gi\|... - gi\|28895631\|ref\|NP_801981.1\| putative repressor (phage associated) [Streptococcus pyogenes SSI-1], g... gi\|28876313 - gi\|28876313\|ref\|NP_795491.1\| putative cI-like repressor [Streptococcus pyogenes phage 315.3] gi\|19748643, gi\|... - gi\|19748643\|gb\|AAL98076.1\| putative repressor [Streptococcus pyogenes MGAS8232], gi\|19746441\|ref\|NP_...	91.0	[0..3]	[133..1]
gi\|116609259, gi... - gi\|66963298\|ref\|ZP_00410870.1\| Helix-turn-helix motif:Protein of unknown function DUF955 [Arthrobact...	90.0	[0..5]	[133..26]

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Predicted Domain #1

Region A:
Residues: [1-135]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MKNETFGARL LHRRKKLKLS QAALGKLVKV AHVTISQWER DETQPAGKRL FALSQALQCS  60
   61 PTWLLFGDED KQPGEPIPDN QPAILTEDQK ELLQLFDALP ESEQKALLSE MRARVENFNK 120
  121 LFEELLKARK RSANK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	11.69897
Match:	1adrA
Description:	DETERMINATION OF THE NUCLEAR MAGNETIC RESONANCE STRUCTURE OF THE DNA-BINDING DOMAIN OF THE P22 C2 REPRESSOR (1-76) IN SOLUTION AND COMPARISON WITH THE DNA-BINDING DOMAIN OF THE 434 REPRESSOR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
DNA binding	3.60509310049517	bayes_pls_golite062009
transcription regulator activity	3.48897156115814	bayes_pls_golite062009
nucleic acid binding	3.34114111237501	bayes_pls_golite062009
binding	2.84855827811506	bayes_pls_golite062009
transcription factor activity	2.15956406789231	bayes_pls_golite062009
catalytic activity	0.374904657353081	bayes_pls_golite062009
RNA polymerase II transcription factor activity	0.29966985317584	bayes_pls_golite062009
sequence-specific DNA binding	0.11459677079129	bayes_pls_golite062009
transcription repressor activity	0.0485771867742395	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: