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View Structure Prediction Details

Protein: EFM6_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 246 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EFM6_YEAST.

Description E-value Query
Range		 Subject
Range
YNL024C - Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluoresce...
EFM6_YEAST - Protein-lysine N-methyltransferase EFM6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
gi|151944504 - gi|151944504|gb|EDN62782.1| conserved protein [Saccharomyces cerevisiae YJM789]
gi|190409021 - gi|190409021|gb|EDV12286.1| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]
gi|207341629 - gi|207341629|gb|EDZ69630.1| YNL024Cp-like protein [Saccharomyces cerevisiae AWRI1631]
 8.0E-55 [1..246] [1..246]
gi|14603247, gi|... - gi|14603247|gb|AAH10084.1| Family with sequence similarity 86, member A [Homo sapiens], gi|119605642...
 2.0E-40 [1..236] [89..320]
gi|10177622, gi|... - gi|15240506|ref|NP_199767.1| unknown protein [Arabidopsis thaliana], gi|10177622|dbj|BAB10769.1| unn...
 2.0E-38 [8..246] [29..263]
gi|12834129 - gi|12834129|dbj|BAB22797.1| unnamed protein product [Mus musculus]
 3.0E-31 [22..239] [10..203]
nnt1 - nicotinamide N-methyltransferase Nnt1
NNT1_SCHPO - Protein N-methyltransferase nnt1 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=nnt1 PE=3...
 8.0E-31 [2..236] [3..234]

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Predicted Domain #1
Region A:
Residues: [1-246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MESIFGGFGD LVVPRPKEHL GQTDLSFGGK LLPALKICED GGESGCGGKV WIAGELLCEY  60
   61 ILEKSVDHLL SKTVNGTKQF KKVLELGSGT GLVGLCVGLL EKNTFHDGTK VYVTDIDKLI 120
  121 PLLKRNIELD EVQYEVLARE LWWGEPLSAD FSPQEGAMQA NNVDLVLAAD CVYLEEAFPL 180
  181 LEKTLLDLTH CINPPVILMA YKKRRKADKH FFNKIKRNFD VLEITDFSKF EHYLKERTHL 240
  241 FQLIRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 21.522879
Match: 1g6q1_
Description: Arginine methyltransferase, HMT1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
rRNA methyltransferase activity 2.5924681776558 bayes_pls_golite062009
methyltransferase activity 2.33136602917122 bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity 2.27124437527134 bayes_pls_golite062009
transferase activity, transferring one-carbon groups 2.25588491617587 bayes_pls_golite062009
N-methyltransferase activity 2.20971449561619 bayes_pls_golite062009
RNA methyltransferase activity 1.66698836347262 bayes_pls_golite062009
catalytic activity 1.25333584501255 bayes_pls_golite062009
transferase activity 1.07321114919891 bayes_pls_golite062009
rRNA (adenine) methyltransferase activity 0.794703281700029 bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity 0.716476158062361 bayes_pls_golite062009
tRNA methyltransferase activity 0.119135438445203 bayes_pls_golite062009
rRNA (guanine) methyltransferase activity 0.0854264678700428 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [153-246] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PQEGAMQANN VDLVLAADCV YLEEAFPLLE KTLLDLTHCI NPPVILMAYK KRRKADKHFF  60
   61 NKIKRNFDVL EITDFSKFEH YLKERTHLFQ LIRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 27.69897
Match: 1or8A
Description: Structure of the Predominant protein arginine methyltransferase PRMT1
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle