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View Structure Prediction Details

Protein: YEH1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 573 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for YEH1_YEAST.

Description E-value Query
Range
Subject
Range
YEH1 - Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl este...
YEH1_YEAST - Sterol esterase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=YEH1 PE=1 SV=1
0.0 [1..573] [1..573]
gi|12844223 - gi|12844223|dbj|BAB26283.1| unnamed protein product [Mus musculus]
4.0E-95 [170..541] [26..392]
LIPF - lipase, gastric
8.0E-95 [172..544] [29..396]

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Predicted Domain #1
Region A:
Residues: [1-138]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSAVLKRA RNLLATFIVC CFMAVVLVLA LAHHFINEHR DTRSSSTQIE VDDESKRNVH  60
   61 HDHVLTRTNA YATPYLDLEH DKKNGIVYDH TRTVVRKKNH EVGSSSLHKN LFHKFLTKLI 120
  121 FRFIEKEKVT EGVTQGKF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [139-573]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NNSSNEIANH EPVFEKIPVQ CDNPLQNLIL SEDLTLVADL NYYFNQYNIQ IEEFRLETED  60
   61 GFVIDLWHLI PKYRTTDSDK KKRPPILMLH GLLQSSGSFA SNGRKSLAYF LYQSGYDIWL 120
  121 GNNRCGFRPE WNEAKVPTLA SRWDWDLREM VKYDLTLLID TVLAKTQFEK LTLISHSQGT 180
  181 TQGFMGLVNE DKFFPPGSGS KESFFTSKIA NYIALAPAVY PGPLLNEKLF VKLMTKEIEN 240
  241 PWFFGETSFF EIMMIVRNLC VGESLFSFVC YTIFNYLFDW NDTLWDTALR DRHFLFSPVH 300
  301 VSVKLMQWWL SPDPNKVSFK FGSHKMFPDN VKWFSDASKA PNIYLFVPKQ DRLVDGERLI 360
  361 NHFVNVESNV NYKIWYIDEY AHIDVLWAHD VIERIGKPIL QNLNNYYSKK PSSAFESDCS 420
  421 DTEVETELEM VAEKA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 307.616428
Match: 1hlgA_
Description: Gastric lipase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity 3.20549979663539 bayes_pls_golite062009
palmitoyl-(protein) hydrolase activity 2.5858992959971 bayes_pls_golite062009
palmitoyl-CoA hydrolase activity 1.62335985481548 bayes_pls_golite062009
catalytic activity 1.39629727416851 bayes_pls_golite062009
triglyceride lipase activity 1.2959733599348 bayes_pls_golite062009
sterol esterase activity 1.21262745914703 bayes_pls_golite062009
thiolester hydrolase activity 1.18565704009692 bayes_pls_golite062009
peptidase activity 0.858311047004898 bayes_pls_golite062009
lipase activity 0.849473630399459 bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides 0.590445773074315 bayes_pls_golite062009
hydrolase activity, acting on ester bonds 0.459339891351725 bayes_pls_golite062009
carboxylesterase activity 0.424330502936163 bayes_pls_golite062009
acyl-CoA thioesterase activity 0.35429970866093 bayes_pls_golite062009
binding 0.351031277062254 bayes_pls_golite062009
receptor binding 0.101189098492974 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle