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View Structure Prediction Details

Protein: VPS33_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 691 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for VPS33_YEAST.

Description E-value Query
Range
Subject
Range
VPS33_YEAST - Vacuolar protein sorting-associated protein 33 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S28...
VPS33 - ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essen...
gi|151940917 - gi|151940917|gb|EDN59299.1| vacuolar sorting protein [Saccharomyces cerevisiae YJM789]
0.0 [1..691] [1..691]
SLY1_DROVI - Protein sly1 homolog OS=Drosophila virilis GN=Slh PE=3 SV=1
0.0 [31..691] [2..644]
gi|1944130 - gi|1944130|dbj|BAA19547.1| hunc18b2 [Homo sapiens]
0.0 [52..578] [22..537]
STXB2_CANLF - Syntaxin-binding protein 2 OS=Canis lupus familiaris GN=STXBP2 PE=2 SV=1
0.0 [39..578] [12..537]
STXB2_MOUSE - Syntaxin-binding protein 2 OS=Mus musculus GN=Stxbp2 PE=1 SV=1
0.0 [52..578] [22..537]
gi|7321218, gi|1... - gi|7321218|emb|CAA73264.2| sec1-like protein [Loligo pealei], gi|13096246|pdb|1FVH|A Chain A, Crysta...
0.0 [42..577] [7..541]

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Predicted Domain #1
Region A:
Residues: [1-240]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRFWNTKKF SLTNADGLCA TLNEISQNDE VLVVQPSVLP VLNSLLTFQD LTQSTPVRKI  60
   61 TLLDDQLSDD LPSALGSVPQ MDLIFLIDVR TSLRLPPQLL DAAQKHNLSS LHIIYCRWKP 120
  121 SFQNTLEDTE QWQKDGFDLN SKKTHFPNVI ESQLKELSNE YTLYPWDLLP FPQIDENVLL 180
  181 THSLYNMENV NMYYPNLRSL QSATESILVD DMVNSLQSLI FETNSIITNV VSIGNLSKRC 240
  241 

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
SNARE binding 3.42828022195984 bayes_pls_golite062009
binding 2.63582271791607 bayes_pls_golite062009
syntaxin binding 2.11416428645287 bayes_pls_golite062009
protein binding 1.92978960054246 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [241-396]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SHLLKKRIDE HQTENDLFIK GTLYGERTNC GLEMDLIILE RNTDPITPLL TQLTYAGILD  60
   61 DLYEFNSGIK IKEKDMNFNY KEDKIWNDLK FLNFGSIGPQ LNKLAKELQT QYDTRHKAES 120
  121 VHEIKEFVDS LGSLQQRQAF LKNHTTLSSD VLKVVE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [397-609]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TEEYGSFNKI LELELEILMG NTLNNDIEDI ILELQYQYEV DQKKILRLIC LLSLCKNSLR  60
   61 EKDYEYLRTF MIDSWGIEKC FQLESLAELG FFTSKTGKTD LHITTSKSTR LQKEYRYISQ 120
  121 WFNTVPIEDE HAADKITNEN DDFSEATFAY SGVVPLTMRL VQMLYDRSIL FHNYSSQQPF 180
  181 ILSREPRVSQ TEDLIEQLYG DSHAIEESIW VPG

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 166.9897
Match: 1fvfA_
Description: Neuronal Sec1, NSec1
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [610-691]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TITKKINASI KSNNRRSIDG SNGTFHAAED IALVVFLGGV TMGEIAIMKH LQKILGKKGI  60
   61 NKRFIIIADG LINGTRIMNS IS

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.719 0.261 fungal-type vacuole membrane c.52.1 Restriction endonuclease-like
View Download 0.739 0.052 fungal-type vacuole membrane d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.832 0.023 fungal-type vacuole membrane c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.726 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.703 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.617 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.594 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.583 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.531 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.525 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.518 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.479 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.470 N/A N/A d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.468 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.457 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.455 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.454 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.450 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.449 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.448 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.438 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.434 N/A N/A d.68.4 YhbY-like
View Download 0.431 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.431 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.428 N/A N/A g.7.1 Snake toxin-like
View Download 0.426 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.413 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.413 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.412 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.409 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.406 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.398 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.396 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.395 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.393 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.392 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.383 N/A N/A d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.379 N/A N/A b.1.2 Fibronectin type III
View Download 0.375 N/A N/A d.58.49 YajQ-like
View Download 0.374 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.368 N/A N/A d.95.2 Homing endonucleases
View Download 0.367 N/A N/A d.79.3 L30e-like
View Download 0.367 N/A N/A d.68.3 SirA-like
View Download 0.362 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.360 N/A N/A d.58.5 GlnB-like
View Download 0.358 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.355 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.354 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.354 N/A N/A d.52.5 Probable GTPase Der, C-terminal domain
View Download 0.353 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.348 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.348 N/A N/A d.79.3 L30e-like
View Download 0.347 N/A N/A d.68.4 YhbY-like
View Download 0.346 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.343 N/A N/A b.71.1 Glycosyl hydrolase domain
View Download 0.343 N/A N/A d.13.1 HIT-like
View Download 0.342 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.339 N/A N/A b.1.2 Fibronectin type III
View Download 0.338 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.338 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.337 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.336 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.336 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.335 N/A N/A c.55.7 Methylated DNA-protein cysteine methyltransferase domain
View Download 0.335 N/A N/A d.13.1 HIT-like
View Download 0.334 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.333 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.331 N/A N/A c.52.1 Restriction endonuclease-like
View Download 0.331 N/A N/A d.58.4 Dimeric alpha+beta barrel
View Download 0.330 N/A N/A d.95.2 Homing endonucleases
View Download 0.328 N/A N/A d.13.1 HIT-like
View Download 0.325 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.324 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.324 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.320 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.318 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.317 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.316 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.314 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.311 N/A N/A d.79.3 L30e-like
View Download 0.310 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.307 N/A N/A d.118.1 N-acetylmuramoyl-L-alanine amidase-like
View Download 0.293 N/A N/A d.68.1 Translation initiation factor IF3, C-terminal domain
View Download 0.292 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.288 N/A N/A d.68.4 YhbY-like
View Download 0.284 N/A N/A c.48.1 TK C-terminal domain-like
View Download 0.283 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.280 N/A N/A c.102.1 Cell-division inhibitor MinC, N-terminal domain
View Download 0.277 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.273 N/A N/A d.95.2 Homing endonucleases
View Download 0.270 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.269 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.267 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.265 N/A N/A d.58.44 Multidrug efflux transporter AcrB pore domain; PN1, PN2, PC1 and PC2 subdomains
View Download 0.264 N/A N/A c.23.5 Flavoproteins
View Download 0.264 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.264 N/A N/A c.23.1 CheY-like
View Download 0.262 N/A N/A d.16.1 FAD-linked reductases, C-terminal domain
View Download 0.262 N/A N/A d.13.1 HIT-like
View Download 0.262 N/A N/A d.58.11 EF-G/eEF-2 domains III and V
View Download 0.260 N/A N/A d.79.1 YjgF-like
View Download 0.257 N/A N/A d.129.1 TATA-box binding protein-like
View Download 0.256 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.255 N/A N/A c.32.1 Tubulin/Dihydroxyacetone kinase nucleotide-binding domain
View Download 0.253 N/A N/A d.15.7 Immunoglobulin-binding domains
View Download 0.253 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.252 N/A N/A d.129.2 Phosphoglucomutase, C-terminal domain
View Download 0.252 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.250 N/A N/A d.130.1 S-adenosylmethionine synthetase
View Download 0.250 N/A N/A d.95.2 Homing endonucleases
View Download 0.247 N/A N/A d.79.1 YjgF-like
View Download 0.245 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.244 N/A N/A c.59.1 MurD-like peptide ligases, peptide-binding domain
View Download 0.243 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.243 N/A N/A c.95.1 Thiolase-like
View Download 0.241 N/A N/A c.46.1 Rhodanese/Cell cycle control phosphatase
View Download 0.241 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.240 N/A N/A d.58.12 eEF-1beta-like
View Download 0.240 N/A N/A d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.239 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.238 N/A N/A d.74.5 Hypothetical protein Yml108w
View Download 0.238 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.238 N/A N/A d.203.1 DsrC, the gamma subunit of dissimilatory sulfite reductase
View Download 0.238 N/A N/A d.13.1 HIT-like
View Download 0.238 N/A N/A d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.235 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.234 N/A N/A d.13.1 HIT-like
View Download 0.234 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.233 N/A N/A d.95.2 Homing endonucleases
View Download 0.231 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.230 N/A N/A d.199.1 DNA-binding C-terminal domain of the transcription factor MotA
View Download 0.229 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.228 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.228 N/A N/A d.74.3 RBP11-like subunits of RNA polymerase
View Download 0.225 N/A N/A d.95.2 Homing endonucleases
View Download 0.223 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.221 N/A N/A c.23.1 CheY-like
View Download 0.221 N/A N/A c.95.1 Thiolase-like
View Download 0.221 N/A N/A d.58.10 Acylphosphatase-like
View Download 0.220 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.218 N/A N/A a.6.1 Putative DNA-binding domain
View Download 0.218 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.217 N/A N/A d.58.5 GlnB-like
View Download 0.216 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.214 N/A N/A d.130.1 S-adenosylmethionine synthetase
View Download 0.214 N/A N/A c.48.1 TK C-terminal domain-like
View Download 0.213 N/A N/A d.230.3 Amyloid beta a4 protein copper binding domain (domain 2)
View Download 0.210 N/A N/A c.2.1 NAD(P)-binding Rossmann-fold domains
View Download 0.210 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.209 N/A N/A d.58.20 NAD-binding domain of HMG-CoA reductase
View Download 0.209 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.205 N/A N/A c.52.2 tRNA splicing endonuclease, C-terminal domain
View Download 0.205 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.205 N/A N/A a.6.1 Putative DNA-binding domain
View Download 0.204 N/A N/A d.109.1 Actin depolymerizing proteins
View Download 0.204 N/A N/A d.79.3 L30e-like
View Download 0.203 N/A N/A d.79.2 Tubulin/Dihydroxyacetone kinase C-terminal domain
View Download 0.201 N/A N/A c.13.2 Anti-sigma factor antagonist SpoIIaa


YRC Informatics Platform - Version 3.0
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