YRC Public Data Repository - Protein Structure Prediction

Protein:	TRM6_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	478 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRM6_YEAST.

Description	E-value	Query Range	Subject Range
TRM6_YEAST - tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 OS=Saccharomyces cerevisiae (st... GCD10 - Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of ...	0.0	[1..478]	[1..478]
TRM6_SCHPO - tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6 OS=Schizosaccharomyces pombe (s... gcd10 - translation initiation factor eIF-3 gamma subunit Gcd10	0.0	[5..457]	[6..440]
gi\|7486467, gi\|1... - pir\|\|T02474 hypothetical protein At2g45730 [imported] - Arabidopsis thaliana, gi\|3386622\|gb\|AAC2855...	0.0	[54..448]	[42..443]
gi\|7297137, gi\|2... - gi\|7297137\|gb\|AAF52404.1\| CG9596, isoform A [Drosophila melanogaster], gi\|24582252\|ref\|NP_609048.1\| ...	0.0	[30..448]	[33..463]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[147..448]	[14..332]
gi\|6330102 - gi\|6330102\|dbj\|BAA86467.1\| KIAA1153 protein [Homo sapiens]	3.0E-96	[20..377]	[56..412]
CH60_EHRCR - 60 kDa chaperonin OS=Ehrlichia chaffeensis (strain ATCC CRL-10679 / Arkansas) GN=groL PE=3 SV=1 CH60_EHRCH - 60 kDa chaperonin OS=Ehrlichia chaffeensis GN=groL PE=3 SV=1	0.004	[46..159]	[38..145]
CH60_EHRRW - 60 kDa chaperonin OS=Ehrlichia ruminantium (strain Welgevonden) GN=groL PE=3 SV=2 gi\|109676789 - gi\|109676789\|gb\|ABG37800.1\| 60 kDa chaperonin [Ehrlichia ruminantium] CH60_EHRRG - 60 kDa chaperonin OS=Ehrlichia ruminantium (strain Gardel) GN=groL PE=3 SV=1	0.005	[46..159]	[38..145]
CH60_EHRCA - 60 kDa chaperonin (Fragment) OS=Ehrlichia canis GN=groL PE=3 SV=1	0.006	[46..159]	[38..145]

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Predicted Domain #1

Region A:
Residues: [1-324]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNALTTIDFN QHVIVRLPSK NYKIVELKPN TSVSLGKFGA FEVNDIIGYP FGLTFEIYYD  60
   61 GEEVSSDENR DSKPKNKIPI GKVRLLSQEI KDVNNDKDDG QSEPPLSIKE KSVSLELSSI 120
  121 DSSATNQNLV NMGSKAQELT VEEIEKMKQE SLSSKEIIDK IIKSHKSFHN KTVYSQEKYV 180
  181 NRKKQKFAKY FTVEYLSSSN LLQFLIDKGD IQRVLDMSQE SMGMLLNLAN IQSEGNYLCM 240
  241 DETGGLLVYF LLERMFGGDN ESKSKGKVIV IHENEHANLD LLKFANYSEK FIKEHVHTIS 300
  301 LLDFFEPPTL QEIQSRFTPL PKEE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

		MCM Score	GO Score	GO Term	SCOP Match	SCOP Description
View	Download	0.338	N/A	N/A	d.109.1	Actin depolymerizing proteins
View	Download	0.295	N/A	N/A	a.118.8	TPR-like
View	Download	0.279	N/A	N/A	b.34.9	Tudor/PWWP/MBT
View	Download	0.273	N/A	N/A	b.24.1	Hyaluronate lyase-like, C-terminal domain
View	Download	0.233	N/A	N/A	g.45.1	Pyk2-associated protein beta ARF-GAP domain

Predicted Domain #2

Region A:
Residues: [325-478]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ARALKGGKKN SYYRKLRWYN TQWQILELTG EFLYDGLVMA TTLHLPTLVP KLAEKIHGSR  60
   61 PIVCYGQFKE TLLELAHTLY SDLRFLAPSI LETRCRPYQS IRGKLHPLMT MKGGGGYLMW 120
  121 CHRVIPAPEP VSENATAADS SEKLAEHGAK KQKI

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
tRNA (adenine-N1-)-methyltransferase activity	8.35052619058198	bayes_pls_golite062009
tRNA (adenine)-methyltransferase activity	8.35052619058198	bayes_pls_golite062009
tRNA methyltransferase activity	7.44275105246879	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	6.5439125367639	bayes_pls_golite062009
methyltransferase activity	3.68431317301075	bayes_pls_golite062009
N-methyltransferase activity	3.64494850793256	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	3.60853685152199	bayes_pls_golite062009
protein methyltransferase activity	3.51986359093355	bayes_pls_golite062009
histone methyltransferase activity	2.666651371662	bayes_pls_golite062009
RNA methyltransferase activity	2.63941856307703	bayes_pls_golite062009
arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	1.99340565364513	bayes_pls_golite062009
transferase activity	1.97261773840408	bayes_pls_golite062009
rRNA methyltransferase activity	1.85380504590369	bayes_pls_golite062009
DNA-methyltransferase activity	1.77527486495102	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.64765900536818	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	1.54257365884902	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	1.54257365884902	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.27753381141602	bayes_pls_golite062009
catalytic activity	1.16970557486814	bayes_pls_golite062009
transcription regulator activity	0.953292160159369	bayes_pls_golite062009
nucleic acid binding	0.750060357052574	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.735680462496249	bayes_pls_golite062009
DNA binding	0.728534001468705	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.51222176401398	bayes_pls_golite062009
binding	0.486361285495359	bayes_pls_golite062009
RNA binding	0.413112349791396	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.286806504860858	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	0.113328595762489	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	0.0390774859535424	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: