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View Structure Prediction Details

Protein: SPS22_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 463 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SPS22_YEAST.

Description E-value Query
Range
Subject
Range
SPS22 - Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of t...
SPS22_YEAST - Sporulation-specific protein 22 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SPS22 PE...
0.0 [1..463] [1..463]
meu10 - GPI anchored cell surface protein
MEU10_SCHPO - Meiotic expression up-regulated protein 10 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN...
8.0E-67 [53..402] [11..351]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
1.0E-65 [40..407] [17..373]
gi|2388938 - gi|2388938|emb|CAB11673.1| SPAC1705.03c [Schizosaccharomyces pombe]
1.0E-60 [56..406] [6..351]

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Predicted Domain #1
Region A:
Residues: [1-166]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNRITRKSCL FAIIFASLFV THALGAAIDP PRRPHNVKPF HNGNLELQRR ANEPFFEIDV  60
   61 KSLNTNSPIS ELCKKDLHVI ESSHDLFHLQ NQCEFILGSL KVTNYDSNIL DLNSLRAIGG 120
  121 DLIIQDSPEL IRIQAGNLNK IEGLFQLQGL TSLVSVEIPT LKFCQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 23.522879
Match: 1igrA_
Description: Type 1 insulin-like growth factor receptor extracellular domain; Type 1 insulin-like growth factor receptor Cys-rich domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor activity 1.64987101746707 bayes_pls_golite062009
transmembrane receptor activity 1.34503183418293 bayes_pls_golite062009
binding 1.08525898490902 bayes_pls_golite062009
protein binding 0.669091045213589 bayes_pls_golite062009
signal transducer activity 0.499118819144462 bayes_pls_golite062009
molecular transducer activity 0.499118819144462 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [167-411]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LEWKVVPILN YVSMDSQNIE IIKDIVISDT SLANIENFNK VQEIDTFNIN NNRFLETIHS  60
   61 NVKTIRGQFS VHANAKELEL EMPHLREVEN ITIRDTSLVY LPQLTKVKSS LEFIENYFYE 120
  121 LNLNNLQKIG GTLGIINNVN LIKVNLENLT DIQGGLMIAD NESLEDITFL PNLKQIGGAI 180
  181 FFEGSFKDIM FDSLKLVKGS AFIKSSSNVL DCNKWTNPSN GRSIIRGGKF TCISGKKENT 240
  241 LNVKQ

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 8.0
Match: 1jl5A_
Description: Leucine rich effector protein YopM
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [412-463]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DGTIIEKGYK DLTQEGEDSK KRVISKYANS ANPSMQLDPL LFGTCLVAML LF

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.808 a.5.1 DNA helicase RuvA subunit, C-terminal domain
View Download 0.673 a.4.1 Homeodomain-like
View Download 0.459 a.60.1 SAM/Pointed domain
View Download 0.448 a.144.1 PABC (PABP) domain
View Download 0.422 a.4.5 "Winged helix" DNA-binding domain
View Download 0.415 a.4.5 "Winged helix" DNA-binding domain
View Download 0.408 a.140.4 Recombination endonuclease VII, C-terminal and dimerization domains
View Download 0.356 a.5.7 4-hydroxy-2-oxovalerate aldolase DmpG, communication domain
View Download 0.343 a.56.1 CO dehydrogenase ISP C-domain like
View Download 0.339 a.60.3 C-terminal domain of RNA polymerase alpha subunit
View Download 0.315 a.64.1 Saposin
View Download 0.305 g.37.1 C2H2 and C2HC zinc fingers
View Download 0.294 a.8.1 Bacterial immunoglobulin/albumin-binding domains
View Download 0.293 a.60.2 RuvA domain 2-like
View Download 0.284 a.60.5 Barrier-to-autointegration factor, BAF
View Download 0.284 a.44.1 Disulphide-bond formation facilitator (DSBA), insertion domain
View Download 0.281 a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.277 a.64.1 Saposin
View Download 0.270 a.4.1 Homeodomain-like
View Download 0.266 a.112.1 Description not found.
View Download 0.265 a.57.1 Protein HNS-dependent expression A; HdeA
View Download 0.263 a.4.5 "Winged helix" DNA-binding domain
View Download 0.262 a.2.3 Chaperone J-domain
View Download 0.251 a.4.5 "Winged helix" DNA-binding domain
View Download 0.244 a.140.3 Rho termination factor, N-terminal domain
View Download 0.241 a.159.1 Protein serine/threonine phosphatase 2C, C-terminal domain
View Download 0.240 a.4.5 "Winged helix" DNA-binding domain
View Download 0.239 a.4.7 Ribosomal protein L11, C-terminal domain
View Download 0.233 a.60.12 DNA polymerase beta-like, second domain
View Download 0.221 a.159.2 FF domain
View Download 0.213 a.16.1 S15/NS1 RNA-binding domain
View Download 0.207 a.60.1 SAM/Pointed domain


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