YRC Public Data Repository - Protein Structure Prediction

Protein:	SAY1_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	424 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SAY1_YEAST.

Description	E-value	Query Range	Subject Range
SAY1_YEAST - Steryl acetyl hydrolase 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SAY1 PE=1 SV=1 SAY1 - Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integr... gi\|190406733 - gi\|190406733\|gb\|EDV10000.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a]	0.0	[1..424]	[1..424]
CES1D_RAT - Carboxylesterase 1D OS=Rattus norvegicus GN=Ces1d PE=1 SV=2 gi\|57554 - gi\|57554\|emb\|CAA46391.1\| carboxylesterase [Rattus rattus]	3.0E-68	[55..353]	[9..322]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	4.0E-68	[55..353]	[9..322]
CES1D_MOUSE - Carboxylesterase 1D OS=Mus musculus GN=Ces1d PE=1 SV=1	8.0E-68	[55..353]	[9..322]
CES1D_RAT - Carboxylesterase 1D OS=Rattus norvegicus GN=Ces1d PE=1 SV=2 gi\|57554 - gi\|57554\|emb\|CAA46391.1\| carboxylesterase [Rattus rattus]	1.0E-67	[55..353]	[9..322]

Back

Predicted Domain #1

Region A:
Residues: [1-424]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MAANSGLDSK VEYYRLQENE IISAVSSEDA DQNDAGFRLS TIHLHLFHGL KFAALLFTVV  60
   61 PVFIILDSMK IIFQRKRRFC LDHVNRSFLR QSSWILDERI CQYVLNPLFV CLYPSTFSSP 120
  121 TYVKCNIPIE DQKSPENNIF QDHQLNAPKI VSTKFYQYVM PEGFDPTTDP VLVFYHGGGY 180
  181 ALKLTPTSFS FLNNMRNAFP KMAILVPDYT VTATDDQSKK YPLQILQNVA IFDYVVKTMG 240
  241 CKNVVIMGDS AGGNAVLNIV LYLRKCHREI YPKKVIAISP WANATFFHEG EKEYMQGTQE 300
  301 WDGLCLKSHS MFGRMFVGNN PNVDFTSDPF VNIEKNFETK MWQDILKKCS VMITYGSDEL 360
  361 LSFQNKILAK KMSDASEGCN HFTAKNVLVE HQGYHTGPIL NYSRNMDRWT NIPSIARILE 420
  421 FMQS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.0
Match:	1k4yA_
Description:	Mammalian carboxylesterase (liver carboxylesterase I)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.39629727416851	bayes_pls_golite062009
sterol esterase activity	1.21262745914703	bayes_pls_golite062009
lipase activity	0.849473630399459	bayes_pls_golite062009
carboxylesterase activity	0.424330502936163	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	0.264183693934251	bayes_pls_golite062009
hydrolase activity	0.0199633894876208	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: