YRC Public Data Repository - Protein Structure Prediction

Protein:	NU170_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	1502 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NU170_YEAST.

Description	E-value	Query Range	Subject Range
gi\|2947312, gi\|2... - gi\|2981204\|gb\|AAC06247.1\| nucleoporin [Drosophila melanogaster], gi\|2947312\|gb\|AAC05386.1\| nucleopor...	0.0	[156..1490]	[78..1355]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	0.0	[156..1490]	[78..1355]
NUP170 - Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; i... NU170_YEAST - Nucleoporin NUP170 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=NUP170 PE=1 SV=1	0.0	[1..1502]	[1..1502]
SPAC890.06 - nucleoporin Nup157 /170 NG06_SCHPO - Probable nucleoporin C890.06 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC890.06 PE...	0.0	[142..1457]	[56..1259]
NUP155 - nucleoporin 155kDa	0.0	[81..479]	[3..404]
NU155_RAT - Nuclear pore complex protein Nup155 OS=Rattus norvegicus GN=Nup155 PE=1 SV=1	0.0	[81..479]	[2..403]

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Predicted Domain #1

Region A:
Residues: [1-75]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MFQSFFHNNG PAAAGETFSD SRSYPLTNHQ EVPRNGLNEL ASSATKAQQQ PTHILNSYPI  60
   61 TGSNPLMRAS AMGAT

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [76-1502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSINPNMSN MNEHIRVSGM GTSKPLDLAG KYIDHLQHKD SNTPVLDERS YYNSGVDYNF  60
   61 SREKNGLGAF TPFEKQDVFN IPDEILHEFS TSQTKTDMGI FPELNRCWIT IDNKLILWNI 120
  121 NNDNEYQVVD DMKHTIQKVA LVRPKPNTFV PAVKHLLLIS TTMELFMFAI SLDKATNELS 180
  181 VFNTHLSVPV QGIDVIDIVS HERSGRIFFA GQASGLNIWE LHYSGSDDWF NSKCSKVCLT 240
  241 KSALLSLLPT NMLSQIPGVD FIQALFEDNS NGNGGFSQET ITQLTIDQQR GIIYSLSSKS 300
  301 TIRAYVITEK SLEGPMSIEP AYISRIIGTT TARAAPILGP KYLKIVKISS VAPEENNNLF 360
  361 LVALTVGGVR LYFNGSMGRF NIEALRLESI KFPPSSVTPE VIQQELLHQQ QEQAKRSFPF 420
  421 FSNLMSSEPV LLKFQKKSSV LLETTKASTI ISPGIFFSAV IKSSQQTHQQ EKKENSSVTG 480
  481 TTATAGSKTV KQQPVTLQHK LFVSVPDYGI LKTHGKYVEN ATFLETAGPV QQIIPLSGLF 540
  541 NATTKPQGFA NEFATQYTSE TLRVAVLTST SIEIYKYRTP DEIFEDLIDN PLPFVLNYGA 600
  601 AEACSTALFV TCKSNKSEKL RSNALTFLTM GIPGVVDIKP VYNRYSVSTV SSLLSKPTLS 660
  661 TATTNLQQSI TGFSKPSPAN KEDFDLDDVI LSPRFYGIAL LITRLLRDIW GRHVFMTFTD 720
  721 NRVTSHAFIS SSDPITPSIN NLKSDEISQN RNIISKVSIS KDCIEYYLSS INILNEFFIT 780
  781 YGDSISQISA PYVLANNSNG RVIDKTEEVA NQAESIAINA MIKMVQSIKE GLSFLNVLYE 840
  841 ESEVEGFDNQ YLGFKDIISF VSLDVQKDLV KLDFKDLFAP NDKTKSLIRE ILLSIINRNI 900
  901 TKGASIEYTA TALQERCGSF CSASDILGFR AIEHLRRAKE IGLRNYDSLN YHLKNATALL 960
  961 EQIVDDLSIE KLKEAVSMML SVNYYPKSIE FLLNIANSMD KGKLACQYVA NGFLENDDRK1020
 1021 QYYDKRILVY DLVFDTLIKV DELAEKKQSS KTQNQISISN DDEVKLRQKS YEAALKYNDR1080
 1081 LFHYHMYDWL VSQNREEKLL DIETPFILPY LMEKAGSSLK ISNILWVYYS RRSKFFESAE1140
 1141 ILYRLATSNF DITLFERIEF LSRANGFCNS VSPLSQKQRI VQLASRIQDA CEVAGIQGDI1200
 1201 LSLVYTDARI DSAIKDELIK TLDGKILSTS ELFNDFAVPL SYHEIALFIF KIADFRDHEV1260
 1261 IMAKWDELFQ SLRMEFNNTG KKEDSMNFIN LLSNVLIKIG KNVQDSEFIF PIFELFPIVC1320
 1321 NFFYETLPKE HIVSGSIVSI FITAGVSFNK MYYILKELIE TSDSDNSVFN KEMTWLIHEW1380
 1381 YKSDRKFRDI ISYNDIIHLK EYKIDNDPIE KYVKNSGNNL GICFYKE

[Run NCBI BLAST on this sequence.]

Detection Method:	Pfam
Confidence:	1000.0
Match:	PF03177
Description:	Non-repetitive/WGA-negative nucleoporin

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
binding	2.23598589443994	bayes_pls_golite062009
protein binding	1.35242477415251	bayes_pls_golite062009
	1.27327168246392	bayes_pls_golite062009
transporter activity	1.23232041140488	bayes_pls_golite062009
snoRNA binding	1.22563757604746	bayes_pls_golite062009
protein transporter activity	0.946697045757834	bayes_pls_golite062009
substrate-specific transporter activity	0.750051725890322	bayes_pls_golite062009
RNA binding	0.658451712028574	bayes_pls_golite062009
general RNA polymerase II transcription factor activity	0.442203655186701	bayes_pls_golite062009
structural molecule activity	0.281751211382124	bayes_pls_golite062009
cytoskeletal protein binding	0.271959658140432	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.0245411309982146	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [477-712]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IQQELLHQQQ EQAKRSFPFF SNLMSSEPVL LKFQKKSSVL LETTKASTII SPGIFFSAVI  60
   61 KSSQQTHQQE KKENSSVTGT TATAGSKTVK QQPVTLQHKL FVSVPDYGIL KTHGKYVENA 120
  121 TFLETAGPVQ QIIPLSGLFN ATTKPQGFAN EFATQYTSET LRVAVLTSTS IEIYKYRTPD 180
  181 EIFEDLIDNP LPFVLNYGAA EACSTALFVT CKSNKSEKLR SNALTFLTMG IPGVVD

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4

Region A:
Residues: [713-871]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKPVYNRYSV STVSSLLSKP TLSTATTNLQ QSITGFSKPS PANKEDFDLD DVILSPRFYG  60
   61 IALLITRLLR DIWGRHVFMT FTDNRVTSHA FISSSDPITP SINNLKSDEI SQNRNIISKV 120
  121 SISKDCIEYY LSSINILNEF FITYGDSISQ ISAPYVLAN

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5

Region A:
Residues: [872-954]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NSNGRVIDKT EEVANQAESI AINAMIKMVQ SIKEGLSFLN VLYEESEVEG FDNQYLGFKD  60
   61 IISFVSLDVQ KDLVKLDFKD LFA

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #6

Region A:
Residues: [955-1016]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNDKTKSLIR EILLSIINRN ITKGASIEYT ATALQERCGS FCSASDILGF RAIEHLRRAK  60
   61 EI

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7

Region A:
Residues: [1017-1152]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLRNYDSLNY HLKNATALLE QIVDDLSIEK LKEAVSMMLS VNYYPKSIEF LLNIANSMDK  60
   61 GKLACQYVAN GFLENDDRKQ YYDKRILVYD LVFDTLIKVD ELAEKKQSSK TQNQISISND 120
  121 DEVKLRQKSY EAALKY

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #8

Region A:
Residues: [1153-1349]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDRLFHYHMY DWLVSQNREE KLLDIETPFI LPYLMEKAGS SLKISNILWV YYSRRSKFFE  60
   61 SAEILYRLAT SNFDITLFER IEFLSRANGF CNSVSPLSQK QRIVQLASRI QDACEVAGIQ 120
  121 GDILSLVYTD ARIDSAIKDE LIKTLDGKIL STSELFNDFA VPLSYHEIAL FIFKIADFRD 180
  181 HEVIMAKWDE LFQSLRM

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #9

Region A:
Residues: [1350-1502]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EFNNTGKKED SMNFINLLSN VLIKIGKNVQ DSEFIFPIFE LFPIVCNFFY ETLPKEHIVS  60
   61 GSIVSIFITA GVSFNKMYYI LKELIETSDS DNSVFNKEMT WLIHEWYKSD RKFRDIISYN 120
  121 DIIHLKEYKI DNDPIEKYVK NSGNNLGICF YKE

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: