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View Structure Prediction Details

Protein: NGR1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 672 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for NGR1_YEAST.

Description E-value Query
Range		 Subject
Range
NGR1 - RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochon...
NGR1_YEAST - Negative growth regulatory protein NGR1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=...
 0.0 [1..672] [1..672]
gi|12855391, gi|... - gi|26325704|dbj|BAC26606.1| unnamed protein product [Mus musculus], gi|255652857|ref|NP_001157308.1|...
 0.0 [25..645] [2..567]
PABP1_BOVIN - Polyadenylate-binding protein 1 OS=Bos taurus GN=PABPC1 PE=2 SV=1
gi|109087089 - gi|109087089|ref|XP_001098239.1| PREDICTED: poly(A) binding protein, cytoplasmic 1 isoform 2 [Macaca...
gi|123993665, gi... - gi|168278070|dbj|BAG11013.1| polyadenylate-binding protein 1 [synthetic construct], gi|123999981|gb|...
gi|194036975 - gi|194036975|ref|XP_001927782.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-bind...
PABPC1 - poly(A) binding protein, cytoplasmic 1
gi|73974130, gi|... - gi|73974178|ref|XP_857695.1| PREDICTED: similar to Polyadenylate-binding protein 1 (Poly(A)-binding ...
 7.0E-95 [183..645] [2..560]
PABP1_RAT - Polyadenylate-binding protein 1 OS=Rattus norvegicus GN=Pabpc1 PE=1 SV=1
 2.0E-93 [183..645] [2..560]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 6.0E-93 [33..648] [1..565]
pAbp-PB, pAbp-PA... - The gene polyA-binding protein is referred to in FlyBase by the symbol Dmel\pAbp (CG5119, FBgn000303...
gi|195335482, gi... - gi|195335482|ref|XP_002034394.1| GM21847 [Drosophila sechellia], gi|194126364|gb|EDW48407.1| GM21847...
gi|220946756 - gi|220946756|gb|ACL85921.1| pAbp-PA [synthetic construct]
 1.0E-91 [33..641] [1..567]

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Predicted Domain #1
Region A:
Residues: [1-86] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MMSNVANASQ RQENPYIIPL PPSSTVETST EPPRTLWMGD LDPSFDEATI EEIWSKLDKK  60
   61 VIVKLIRAKK NLLIPCSSTS SSNNNT

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 92.54902
Match: 1cvjA_
Description: Poly(A)-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.27266833016156 bayes_pls_golite062009
binding 2.80563734517858 bayes_pls_golite062009
nucleic acid binding 2.18035791990719 bayes_pls_golite062009
mRNA binding 2.17710836425586 bayes_pls_golite062009
protein binding 1.02232785292059 bayes_pls_golite062009
0.787367154319901 bayes_pls_golite062009
single-stranded RNA binding 0.419268956417989 bayes_pls_golite062009
structural molecule activity 0.106871867442361 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [87-184] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SEENAENQQS ASNSTDQLDN SQMININGIS FIDPSTTQLH HAGYCFVEFE TQKDAKFALS  60
   61 LNATPLPNFY SPTTNSQTNP TFKRTFRLNW ASGATLQS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.28043
Match: 1fxlA_
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.27266833016156 bayes_pls_golite062009
binding 2.80563734517858 bayes_pls_golite062009
nucleic acid binding 2.18035791990719 bayes_pls_golite062009
mRNA binding 2.17710836425586 bayes_pls_golite062009
protein binding 1.02232785292059 bayes_pls_golite062009
0.787367154319901 bayes_pls_golite062009
single-stranded RNA binding 0.419268956417989 bayes_pls_golite062009
structural molecule activity 0.106871867442361 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [185-306] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SIPSTPEFSL FVGDLSPTAT EADLLSLFQT RFKSVKTVRV MTDPLTGSSR CFGFVRFGDE  60
   61 DERRRALIEM SGKWFQGRAL RVAYATPRNN MMLQLQEQQQ QQQQLQQQHQ QLDQEDNNGP 120
  121 LL

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 89.28043
Match: 1fxlA_
Description: Hu antigen D (Hud)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 3.27266833016156 bayes_pls_golite062009
binding 2.80563734517858 bayes_pls_golite062009
nucleic acid binding 2.18035791990719 bayes_pls_golite062009
mRNA binding 2.17710836425586 bayes_pls_golite062009
protein binding 1.02232785292059 bayes_pls_golite062009
0.787367154319901 bayes_pls_golite062009
single-stranded RNA binding 0.419268956417989 bayes_pls_golite062009
structural molecule activity 0.106871867442361 bayes_pls_golite062009

Predicted Domain #4
Region A:
Residues: [307-358] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IKTANNLIQN NSNMLPLNAL HNAPPMHLNE GGISNMRVND SLPSNTYNTD PT

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #5
Region A:
Residues: [359-475] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NTTVFVGGLV PKTTEFQLRS LFKPFGPILN VRIPNGKNCG FVKFEKRIDA EASIQGLQGF  60
   61 IVGGSPIRLS WGRPSSSNAK TNSTIMGASQ YMSSNGLRAP SAASSVDNSK QILEQYA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 13.221849
Match: 1h6kX_
Description: CBP20, 20KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted Domain #6
Region A:
Residues: [476-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 EDKRRLFLHQ QQQQQQQQQQ DGNFSMEQMA HNNYYNYNNY DYHRNKNGSH SDLVNLQRSN  60
   61 VPYMQEDGAL YPHQYSSPSY SLHPTGNQFS NATNNLPQFG NAMSISMQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #7
Region A:
Residues: [585-672] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNGNSNKTAS SMNTNPNTNM IMNSNMNMNM NVNPVPYGMG NGANMYDVSR MMTPPLNIAP  60
   61 NSNNSKSSIM NKHPNRNNVP PIHPSLLH

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 11.0
Match: 1g9lA_
Description: poly(A) binding protein
Matching Structure (courtesy of the PDB):
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle