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View Structure Prediction Details

Protein: ITR1_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 584 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for ITR1_YEAST.

Description E-value Query
Range		 Subject
Range
ITR1_YEAST - Myo-inositol transporter 1 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ITR1 PE=1 SV=...
ITR1 - Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member ...
 0.0 [1..584] [1..584]
KHT2_KLULC - Hexose transporter 2 OS=Kluyveromyces lactis GN=KHT2 PE=3 SV=1
 0.0 [15..576] [2..558]
itr2 - MFS myo-inositol transporter
ITR2_SCHPO - Myo-inositol transporter 2 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=itr2 PE=2 SV=1
 0.0 [4..564] [5..552]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
 0.0 [26..576] [2..559]

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Predicted Domain #1
Region A:
Residues: [1-67] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGIHIPYLTS KTSQSNVGDA VGNADSVEFN SEHDSPSKRG KITLESHEIQ RAPASDDEDR  60
   61 IQIKPVN

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score		 GO
Score		 GO
Term		 SCOP
Match		 SCOP Description
View Download 0.419 0.906 membrane b.1.1 Immunoglobulin

Predicted Domain #2
Region A:
Residues: [68-267] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DEDDTSVMIT FNQSLSPFII TLTFVASISG FMFGYDTGYI SSALISIGTD LDHKVLTYGE  60
   61 KEIVTAATSL GALITSIFAG TAADIFGRKR CLMGSNLMFV IGAILQVSAH TFWQMAVGRL 120
  121 IMGFGVGIGS LIAPLFISEI APKMIRGRLT VINSLWLTGG QLVAYGCGAG LNYVNNGWRI 180
  181 LVGLSLIPTA VQFTCLCFLP

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [320-535] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KVWNTIKELH TVPSNLRALI IGCGLQAIQQ FTGWNSLMYF SGTIFETVGF KNSSAVSIIV  60
   61 SGTNFIFTLV AFFSIDKIGR RTILLIGLPG MTMALVVCSI AFHFLGIKFD GAVAVVVSSG 120
  121 FSSWGIVIIV FIIVFAAFYA LGIGTVPWQQ SELFPQNVRG IGTSYATATN WAGSLVIAST 180
  181 FLTMLQNITP AGTFAFFAGL SCLSTIFCYF CYPELS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 523.0103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.

Predicted functions:

Term Confidence Notes
glycerol transmembrane transporter activity 7.11654923455995 bayes_pls_golite062009
alcohol transmembrane transporter activity 6.7545566917184 bayes_pls_golite062009
polyol transmembrane transporter activity 6.7545566917184 bayes_pls_golite062009
glycerol-3-phosphate transmembrane transporter activity 5.74077413704789 bayes_pls_golite062009
transporter activity 4.09176719149278 bayes_pls_golite062009
substrate-specific transporter activity 3.59744164024479 bayes_pls_golite062009
transmembrane transporter activity 3.5865018981083 bayes_pls_golite062009
substrate-specific transmembrane transporter activity 3.54194478414824 bayes_pls_golite062009
hexose phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
glucose-6-phosphate transmembrane transporter activity 3.3746965264994 bayes_pls_golite062009
sugar:hydrogen symporter activity 2.99050613058546 bayes_pls_golite062009
cation:sugar symporter activity 2.99050613058546 bayes_pls_golite062009
monosaccharide transmembrane transporter activity 2.63293544825311 bayes_pls_golite062009
carbohydrate transmembrane transporter activity 2.62141276633776 bayes_pls_golite062009
sugar transmembrane transporter activity 2.47557586092261 bayes_pls_golite062009
ion transmembrane transporter activity 2.21266150105753 bayes_pls_golite062009
solute:hydrogen symporter activity 2.10485633822652 bayes_pls_golite062009
binding 1.89539096965643 bayes_pls_golite062009
cation transmembrane transporter activity 1.79369588808394 bayes_pls_golite062009
active transmembrane transporter activity 1.59419818573076 bayes_pls_golite062009
secondary active transmembrane transporter activity 1.22264637452409 bayes_pls_golite062009
symporter activity 0.74591237387473 bayes_pls_golite062009
solute:cation symporter activity 0.74591237387473 bayes_pls_golite062009
sugar binding 0.285073104957756 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [268-319] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 DTPRYYVMKG DLARATEVLK RSYTDTSEEI IERKVEELVT LNQSIPGKNV PE

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [536-584] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GLELEEVQTI LKDGFNIKAS KALAKKRKQQ VARVHELKYE PTQEIIEDI

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 523.0103
Match: 1ja5A_
Description: No description for 1ja5A_ was found.
YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle