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View Structure Prediction Details

Protein: GAS2_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 555 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for GAS2_YEAST.

Description E-value Query
Range		 Subject
Range
GAS2 - 1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p
GAS2_YEAST - 1,3-beta-glucanosyltransferase GAS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=GAS2...
 0.0 [1..555] [1..555]
gi|18073453 - gi|18073453|emb|CAC83346.1| GAS-3 homologue [Candida glabrata]
 0.0 [3..518] [2..526]
gi|238881411 - gi|238881411|gb|EEQ45049.1| protein EPD2 precursor [Candida albicans WO-1]
gi|8132882 - gi|8132882|gb|AAF73430.1|AF247190_1 Phr1p [Candida albicans]
 0.0 [11..493] [3..478]
gi|10441335 - gi|10441335|gb|AAG16995.1|AF184907_1 pH-regulated protein 1 [Candida dubliniensis]
 0.0 [11..497] [3..482]
EPD1_CANMA - Protein EPD1 OS=Candida maltosa GN=EPD1 PE=3 SV=1
 0.0 [8..513] [2..485]

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Predicted Domain #1
Region A:
Residues: [1-283] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MNKKQNFYAA IIVAIFLCLQ LSHGSSGVSF EKTPAIKIVG NKFFDSESGE QFFIKGIAYQ  60
   61 LQRSEEELSN ANGAFETSYI DALADPKICL RDIPFLKMLG VNTLRVYAID PTKSHDICME 120
  121 ALSAEGMYVL LDLSEPDISI NRENPSWDVH IFERYKSVID AMSSFPNLLG YFAGNEVTND 180
  181 HTNTFASPFV KAAIRDAKEY ISHSNHRKIP VGYSTNDDAM TRDNLARYFV CGDVKADFYG 240
  241 INMYEWCGYS TYGTSGYRER TKEFEGYPIP VFFSEFGCNL VRP

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 14.38
Match: 1lf1A
Description: Endoglucanase Cel5a
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydrolase activity, acting on glycosyl bonds 4.82709828196015 bayes_pls_golite062009
glucan 1,3-beta-glucosidase activity 4.74305379082042 bayes_pls_golite062009
hydrolase activity, hydrolyzing O-glycosyl compounds 4.01411696184454 bayes_pls_golite062009
chitinase activity 3.78150885614991 bayes_pls_golite062009
glucosidase activity 3.19980164991891 bayes_pls_golite062009
beta-glucosidase activity 2.7000684082902 bayes_pls_golite062009
fucose binding 2.04801447625314 bayes_pls_golite062009
transferase activity, transferring hexosyl groups 1.83793415935297 bayes_pls_golite062009
catalytic activity 1.71182498300466 bayes_pls_golite062009
alpha-amylase activity 1.61063934717843 bayes_pls_golite062009
amylase activity 1.54984242481283 bayes_pls_golite062009
hexosaminidase activity 1.51314432035015 bayes_pls_golite062009
hydrolase activity 0.972016120780314 bayes_pls_golite062009
binding 0.730318626805434 bayes_pls_golite062009
beta-N-acetylhexosaminidase activity 0.560124157008173 bayes_pls_golite062009
nucleic acid binding 0.553733682164788 bayes_pls_golite062009
transmembrane receptor protein tyrosine kinase activity 0.538809900049354 bayes_pls_golite062009
receptor activity 0.495203069605136 bayes_pls_golite062009
transmembrane receptor protein kinase activity 0.465943523894286 bayes_pls_golite062009
hyalurononglucosaminidase activity 0.360736359706209 bayes_pls_golite062009
transmembrane receptor activity 0.292561918090025 bayes_pls_golite062009
DNA binding 0.229593045096518 bayes_pls_golite062009
acid-amino acid ligase activity 0.217146217809487 bayes_pls_golite062009
alpha-1,3-glucan synthase activity 0.161901114278971 bayes_pls_golite062009
carbohydrate binding 0.121376027870322 bayes_pls_golite062009
transferase activity, transferring glycosyl groups 0.111668716138987 bayes_pls_golite062009
integrin binding 0.0319273692198228 bayes_pls_golite062009
alpha-glucosidase activity 0.0243149684125608 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [284-346] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 RPFTEVSALY GNKMSSVWSG GLAYMYFEEE NEYGVVKIND NDGVDILPDF KNLKKEFAKA  60
   61 DPK

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [347-555] 
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GITEEEYLTA KEPTEVESVE CPHIAVGVWE ANEKLPETPD RSKCACLDEI LPCEIVPFGA  60
   61 ESGKYEEYFS YLCSKVDCSD ILANGKTGEY GEFSDCSVEQ KLSLQLSKLY CKIGANDRHC 120
  121 PLNDKNVYFN LESLQPLTSE SICKNVFDSI RNITYNHGDY SKSNPSRSKE SLNVKYPSSE 180
  181 ERENDGTIAF KTSGFVILLI SMIAAGILL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle