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View Structure Prediction Details

Protein: EI2BB_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 381 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for EI2BB_YEAST.

Description E-value Query
Range
Subject
Range
EI2BB_YEAST - Translation initiation factor eIF-2B subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / ...
GCD7 - Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for ...
0.0 [1..381] [1..381]
EIF2B2 - eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa
1.0E-97 [13..376] [6..351]
EI2BB_MOUSE - Translation initiation factor eIF-2B subunit beta OS=Mus musculus GN=Eif2b2 PE=1 SV=1
8.0E-96 [13..376] [6..351]
EI2BB_RABIT - Translation initiation factor eIF-2B subunit beta OS=Oryctolagus cuniculus GN=EIF2B2 PE=1 SV=1
2.0E-95 [11..376] [2..351]
EI2BB_RAT - Translation initiation factor eIF-2B subunit beta OS=Rattus norvegicus GN=Eif2b2 PE=2 SV=1
1.0E-93 [13..376] [6..351]
EI2BB_TAKRU - Translation initiation factor eIF-2B subunit beta OS=Takifugu rubripes GN=eif2b2 PE=3 SV=1
1.0E-91 [11..376] [2..355]
gi|7406745 - gi|7406745|gb|AAF61750.1|AF064872_1 translation initiation factor eIF-2B precursor [Sciaenops ocella...
2.0E-90 [14..376] [6..355]
gi|30680205, gi|... - gi|79313151|ref|NP_001030655.1| eukaryotic translation initiation factor 2B family protein / eIF-2B ...
4.0E-90 [15..376] [1..407]

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Predicted Domain #1
Region A:
Residues: [1-137]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSQAFTSVH PNAATSDVNV TIDTFVAKLK RRQVQGSYAI ALETLQLLMR FISAARWNHV  60
   61 NDLIEQIRDL GNSLEKAHPT AFSCGNVIRR ILAVLRDEVE EDTMSTTVTS TSVAEPLISS 120
  121 MFNLLQKPEQ PHQNRKN

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.768 0.720 translation initiation factor activity a.118.1 ARM repeat
View Download 0.804 0.036 mitochondrion f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.940 0.010 mitochondrion a.118.8 TPR-like
View Download 0.713 0.003 translation initiation factor activity a.74.1 Cyclin-like
View Download 0.824 0.002 translation initiation factor activity a.24.16 Nucleotidyltransferase substrate binding subunit/domain
View Download 0.657 N/A N/A a.46.1 Methionine synthase domain
View Download 0.629 N/A N/A a.126.1 Serum albumin-like
View Download 0.628 N/A N/A d.108.1 Acyl-CoA N-acyltransferases (Nat)
View Download 0.621 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.610 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.604 N/A N/A f.1.4 Bcl-2 inhibitors of programmed cell death
View Download 0.585 N/A N/A c.78.2 Aspartate/glutamate racemase
View Download 0.584 N/A N/A d.14.1 Ribosomal protein S5 domain 2-like
View Download 0.584 N/A N/A a.7.6 Ribosomal protein S20
View Download 0.580 N/A N/A c.37.1 P-loop containing nucleoside triphosphate hydrolases
View Download 0.569 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.544 N/A N/A a.29.2 Bromodomain
View Download 0.543 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.520 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.511 N/A N/A a.74.1 Cyclin-like
View Download 0.501 N/A N/A a.24.17 Group V grass pollen allergen
View Download 0.488 N/A N/A a.142.1 PTS-regulatory domain, PRD
View Download 0.482 N/A N/A a.118.9 ENTH/VHS domain
View Download 0.471 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.470 N/A N/A a.118.8 TPR-like
View Download 0.448 N/A N/A a.26.1 4-helical cytokines
View Download 0.447 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.442 N/A N/A d.43.1 Elongation factor Ts (EF-Ts), dimerisation domain
View Download 0.436 N/A N/A a.29.2 Bromodomain
View Download 0.432 N/A N/A a.63.1 Apolipophorin-III
View Download 0.428 N/A N/A a.118.8 TPR-like
View Download 0.421 N/A N/A a.22.1 Histone-fold
View Download 0.419 N/A N/A a.118.1 ARM repeat
View Download 0.418 N/A N/A a.74.1 Cyclin-like
View Download 0.413 N/A N/A d.122.1 ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase
View Download 0.389 N/A N/A a.118.8 TPR-like
View Download 0.381 N/A N/A a.39.2 Insect pheromon/odorant-binding proteins
View Download 0.380 N/A N/A a.118.11 Cytochrome c oxidase subunit E
View Download 0.379 N/A N/A d.58.26 GHMP Kinase, C-terminal domain
View Download 0.376 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin
View Download 0.374 N/A N/A a.133.1 Phospholipase A2, PLA2
View Download 0.372 N/A N/A a.24.13 Domain of the SRP/SRP receptor G-proteins
View Download 0.371 N/A N/A a.1.1 Globin-like
View Download 0.369 N/A N/A a.29.5 alpha-ketoacid dehydrogenase kinase, N-terminal domain
View Download 0.366 N/A N/A d.173.1 Methionine synthase activation domain-like
View Download 0.363 N/A N/A a.69.1 C-terminal domain of alpha and beta subunits of F1 ATP synthase
View Download 0.353 N/A N/A c.55.3 Ribonuclease H-like
View Download 0.351 N/A N/A a.1.1 Globin-like
View Download 0.346 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.337 N/A N/A a.11.2 Second domain of FERM
View Download 0.335 N/A N/A a.1.1 Globin-like
View Download 0.331 N/A N/A a.26.1 4-helical cytokines
View Download 0.330 N/A N/A a.26.1 4-helical cytokines
View Download 0.330 N/A N/A a.1.1 Globin-like
View Download 0.329 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.329 N/A N/A a.7.3 Succinate dehydrogenase/fumarate reductase flavoprotein C-terminal domain
View Download 0.325 N/A N/A a.1.1 Globin-like
View Download 0.321 N/A N/A c.52.3 Eukaryotic RPB5 N-terminal domain
View Download 0.312 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.309 N/A N/A a.90.1 Transcription factor STAT-4 N-domain
View Download 0.308 N/A N/A a.2.3 Chaperone J-domain
View Download 0.307 N/A N/A d.112.1 Phoshotransferase/anion transport protein
View Download 0.304 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.303 N/A N/A a.26.1 4-helical cytokines
View Download 0.300 N/A N/A a.118.12 Ran-GTPase activating protein 1 (RanGAP1), C-terminal domain
View Download 0.299 N/A N/A a.80.1 DNA polymerase III clamp loader subunits, C-terminal domain
View Download 0.297 N/A N/A a.4.5 "Winged helix" DNA-binding domain
View Download 0.297 N/A N/A a.91.1 Regulator of G-protein signalling, RGS
View Download 0.296 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.295 N/A N/A a.4.3 ARID-like
View Download 0.295 N/A N/A f.21.2 Fumarate reductase respiratory complex transmembrane subunits
View Download 0.292 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.291 N/A N/A a.85.1 Hemocyanin, N-terminal domain
View Download 0.283 N/A N/A a.100.1 6-phosphogluconate dehydrogenase C-terminal domain-like
View Download 0.277 N/A N/A a.160.1 Poly(A) polymerase, middle domain
View Download 0.274 N/A N/A a.118.8 TPR-like
View Download 0.270 N/A N/A a.26.1 4-helical cytokines
View Download 0.270 N/A N/A a.24.10 Histidine-containing phosphotransfer domain, HPT domain
View Download 0.269 N/A N/A a.121.1 Tetracyclin repressor-like, C-terminal domain
View Download 0.263 N/A N/A c.64.1 Pyruvate-ferredoxin oxidoreductase, PFOR, domain III
View Download 0.261 N/A N/A a.24.7 FKBP12-rapamycin-binding domain of FKBP-rapamycin-associated protein (FRAP)
View Download 0.249 N/A N/A d.65.1 Hedgehog/DD-pepidase
View Download 0.248 N/A N/A c.3.1 FAD/NAD(P)-binding domain
View Download 0.245 N/A N/A a.5.4 Elongation factor TFIIS domain 2
View Download 0.243 N/A N/A a.60.9 lambda integrase-like, N-terminal domain
View Download 0.242 N/A N/A f.36.1 Neurotransmitter-gated ion-channel pransmembrane pore
View Download 0.235 N/A N/A a.24.3 Cytochromes
View Download 0.235 N/A N/A a.74.1 Cyclin-like
View Download 0.233 N/A N/A a.24.4 Hemerythrin
View Download 0.231 N/A N/A a.89.1 Methyl-coenzyme M reductase alpha and beta chain C-terminal domain
View Download 0.229 N/A N/A a.71.1 Endoplasmic reticulum protein ERP29, C-domain
View Download 0.229 N/A N/A a.47.2 t-snare proteins
View Download 0.228 N/A N/A a.1.1 Globin-like
View Download 0.226 N/A N/A c.1.1 Triosephosphate isomerase (TIM)
View Download 0.222 N/A N/A d.163.1 DNA breaking-rejoining enzymes
View Download 0.220 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.219 N/A N/A f.32.1 a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)
View Download 0.217 N/A N/A a.71.2 Helical domain of Sec23/24
View Download 0.216 N/A N/A a.1.1 Globin-like
View Download 0.215 N/A N/A a.45.1 Glutathione S-transferase (GST), C-terminal domain
View Download 0.215 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.214 N/A N/A a.24.9 alpha-catenin/vinculin
View Download 0.214 N/A N/A d.79.1 YjgF-like
View Download 0.213 N/A N/A e.37.1 Bifunctional dehydrogenase/ferrochelatase Met8p, dimerisation and C-terminal domains
View Download 0.212 N/A N/A a.19.1 Fertilization protein
View Download 0.211 N/A N/A a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain
View Download 0.211 N/A N/A a.39.1 EF-hand
View Download 0.205 N/A N/A a.61.1 Retroviral matrix proteins
View Download 0.203 N/A N/A a.27.1 Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases
View Download 0.203 N/A N/A a.62.1 Hepatitis B viral capsid (hbcag)
View Download 0.202 N/A N/A a.24.14 FAT domain of focal adhesion kinase
View Download 0.202 N/A N/A a.52.1 Bifunctional inhibitor/lipid-transfer protein/seed storage 2S albumin

Predicted functions:

Term Confidence Notes
translation initiation factor activity 10.1099993541596 bayes_pls_golite062009
translation regulator activity 5.74669335554405 bayes_pls_golite062009
nucleic acid binding 2.17718456512191 bayes_pls_golite062009
transcription regulator activity 1.9283980201455 bayes_pls_golite062009
DNA binding 1.55389679363348 bayes_pls_golite062009
binding 1.53908996868286 bayes_pls_golite062009
catalytic activity 1.31732715713197 bayes_pls_golite062009
translation factor activity, nucleic acid binding 1.09424756417577 bayes_pls_golite062009
transcription factor activity 0.995059566132783 bayes_pls_golite062009
CoA-transferase activity 0.0320953696548698 bayes_pls_golite062009
protein binding 0.0293610121675921 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [138-311]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGSSSMKTK TDYRQVAIQG IKDLIDEIKN IDEGIQQIAI DLIHDHEILL TPTPDSKTVL  60
   61 KFLITARERS NRTFTVLVTE GFPNNTKNAH EFAKKLAQHN IETLVVPDSA VFALMSRVGK 120
  121 VIIGTKAVFV NGGTISSNSG VSSVCECARE FRTPVFAVAG LYKLSPLYPF DVEK

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [376-381]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LDKNKA

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.68
Match: 1m0sA
Description: D-ribose-5-phosphate isomerase (RpiA), catalytic domain; D-ribose-5-phosphate isomerase (RpiA), lid domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3
Region A:
Residues: [312-375]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 FVEFGGSQRI LPRMDPRKRL DTVNQITDYV PPENIDIYIT NVGGFNPSFI YRIAWDNYKQ  60
   61 IDVH

[Run NCBI BLAST on this sequence.]

Detection Method: ORFEUS
Confidence: 10.68
Match: 1m0sA
Description: D-ribose-5-phosphate isomerase (RpiA), catalytic domain; D-ribose-5-phosphate isomerase (RpiA), lid domain
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle