YRC Public Data Repository - Protein Structure Prediction

Protein:	MET5_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	1442 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

[What does the above image mean?]

[Show Ginzu Version Information]

Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for MET5_YEAST.

Description	E-value	Query Range	Subject Range
MET5_SCHPO - Sulfite reductase [NADPH] subunit beta OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=sir... SPAC10F6.01c - sulfite reductase beta subunit	0.0	[45..1442]	[58..1473]
gi\|19068028 - gi\|19068028\|gb\|AAL14263.1\| sulfite reductase [Neurospora crassa]	0.0	[3..1439]	[21..1474]
MET5_YEAST - Sulfite reductase [NADPH] subunit beta OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=M... MET5 - Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by meth...	0.0	[1..1442]	[1..1442]
gi\|9909124 - gi\|9909124\|dbj\|BAB12024.1\| pyruvate: NADP+ oxidoreductase [Euglena gracilis]	0.0	[309..887]	[837..1453]
gi\|192927322, gi... - gi\|75256970\|ref\|ZP_00728546.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|75230026, gi\|... - gi\|75230026\|ref\|ZP_00716536.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|194427921, gi... - gi\|75210973\|ref\|ZP_00711097.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... CYSI_ECO24 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O139:H28 (strain E24377A / ... gi\|13363089, gi\|... - gi\|15832872\|ref\|NP_311645.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 str. Sakai], g... CYSI_SHIB3 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Shigella boydii serotype 18 (strain CDC 3083... CYSI_ECOLU - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O17:K52:H18 (strain UMN026 ... CYSI_ECO55 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain 55989 / EAEC) GN=cy... CYSI_ECO57 - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O157:H7 GN=cysI PE=3 SV=3 gi\|209761638, gi... - pir\|\|C85926 sulfite reductase, alpha subunit [imported] - Escherichia coli (strain O157:H7, substrai... gi\|188494761, gi... - gi\|75512330\|ref\|ZP_00734882.1\| COG0155: Sulfite reductase, beta subunit (hemoprotein) [Escherichia c... gi\|254594104, gi... - gi\|254794704\|ref\|YP_003079541.1\| sulfite reductase, beta subunit, NAD(P)-binding, heme-binding [Esch... gi\|208806526, gi... - gi\|208806526\|ref\|ZP_03248863.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|12517224, gi\|... - gi\|15803281\|ref\|NP_289313.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 EDL933], gi\|12... gi\|195939477 - gi\|195939477\|ref\|ZP_03084859.1\| sulfite reductase subunit beta [Escherichia coli O157:H7 str. EC4024... gi\|208821977, gi... - gi\|208821977\|ref\|ZP_03262297.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|208735118, gi... - gi\|208813841\|ref\|ZP_03255170.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... CYSI_ECOSE - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli (strain SE11) GN=cysI PE=3 ... CYSI_ECO5E - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O157:H7 (strain EC4115 / EH... CYSI_ECO8A - Sulfite reductase [NADPH] hemoprotein beta-component OS=Escherichia coli O8 (strain IAI1) GN=cysI PE... gi\|217319996, gi... - gi\|217327629\|ref\|ZP_03443712.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia c... gi\|189357298, gi... - gi\|189357298\|gb\|EDU75717.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|188015797, gi... - gi\|188015797\|gb\|EDU53919.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189362039, gi... - gi\|189362039\|gb\|EDU80458.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|168762834, gi... - gi\|189366860\|gb\|EDU85276.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189003610, gi... - gi\|189003610\|gb\|EDU72596.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|187769540, gi... - gi\|187769540\|gb\|EDU33384.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189377515, gi... - gi\|189377515\|gb\|EDU95931.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ... gi\|189372136, gi... - gi\|189372136\|gb\|EDU90552.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Escherichia coli ...	0.0	[833..1436]	[1..570]
gi\|145681 - gi\|145681\|gb\|AAA23651.1\| NADPH-sulfite reductase hemoprotein component	0.0	[833..1436]	[3..572]
gi\|153930 - gi\|153930\|gb\|AAA27047.1\| NADPH-sulfite reductase hemoprotein component gi\|153930\|gb\|AAA... - NADPH-sulfite reductase hemoprotein component	0.0	[833..1435]	[3..571]
CYSI_SALTY - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella typhimurium (strain LT2 / SGSC141... lcl\|NC_016856.1_... - [gene=cysI] [protein=sulfite reductase subunit beta] [protein_id=YP_005239061.1] [location=complemen... CYSI_SALTY - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella typhimurium GN=cysI PE=3 SV=3 gi\|167993190, gi... - gi\|205328744\|gb\|EDZ15508.1\| sulfite reductase (NADPH) hemoprotein, beta-component [Salmonella enteri... CYSI_SALTY - Sulfite reductase [NADPH] hemoprotein beta-component OS=Salmonella typhimurium GN=cysI PE=3 SV=3	0.0	[833..1435]	[1..569]

Back

Predicted Domain #1

Region A:
Residues: [1-192]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTASDLLTLP QLLAQYSSSA PQNKVFYTTS TKNSHSSFKG LESVATDATH LLNNQDPLNT  60
   61 IKDQLSKDIL TTVFTDETTL VKSIHHLYSL PNKLPLVITV DLNLQDYSAI PALKDLSFPI 120
  121 LISSDLQTAI SNADSSYKIA TSSLTPVFHF LNLEKIGTST AIEQDIDFPT LEIANEETKV 180
  181 ALSEATDSLT NF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.18
Match:	1ik6A
Description:	E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #2

Region A:
Residues: [193-319]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELVKGKESIT TVIVNLSPYD AEFSSVLPSN VGLIKIRVYR PWNFSKFLEI LPSSVTKIAV  60
   61 LQGVSKKSQS NEFQPFLLDF FGNFNELVSR NIEQVVLTNI GNVNDYGNVI NTVISNINKK 120
  121 EPDNNLF

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	13.18
Match:	1ik6A
Description:	E1-beta subunit of pyruvate dehydrogenase, Pyr module; E1-beta subunit of pyruvate dehydrogenase, C-domain
Matching Structure (courtesy of the PDB):

Predicted Domain #3

Region A:
Residues: [320-679]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGESNEKAEE QAEVTQLISS VKKVVNLEDA YIKVLKQLFS SNLQILNQFS SETIEPSNPE  60
   61 FGFGRFLKQE AQREELISLA KTSLDPSLYL SEDANKIVQL LSKWLSFNGR DLDEAQLQEA 120
  121 NATGLEIFQL LQSNQDSSTV LKFLKIAPTS DSFIFKSSWL IGSDAWSYDL GHSGIQQVLS 180
  181 SRKNINVLLI DSEPYDHRKQ NQDRKKDVGL YAMNYYSAYV ASVAVYASYT QLLTAIIEAS 240
  241 KYNGPSIVLA YLPYNSENDT PLEVLKETKN AVESGYWPLY RFNPVYDDPS TDKEAFSLDS 300
  301 SVIRKQLQDF LDRENKLTLL TRKDPSLSRN LKQSAGDALT RKQEKRSKAA FDQLLEGLSG 360
  361

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	411.228787
Match:	1b0pA_
Description:	Pyruvate-ferredoxin oxidoreductase, PFOR, domain I; Pyruvate-ferredoxin oxidoreductase, PFOR, domains VI; Pyruvate-ferredoxin oxidoreductase, PFOR, domain II; Pyruvate-ferredoxin oxidoreductase, PFOR, domain III; Pyruvate-ferredoxin oxidoreductase, PFOR, domain V
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
acetolactate synthase activity	2.86666318994863	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	2.75586243560276	bayes_pls_golite062009
pyruvate dehydrogenase activity	2.54367237239121	bayes_pls_golite062009
pyruvate dehydrogenase (acetyl-transferring) activity	2.37626222601658	bayes_pls_golite062009
catalytic activity	2.25537597692103	bayes_pls_golite062009
transferase activity, transferring aldehyde or ketonic groups	2.18080419129242	bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors	1.3936144958597	bayes_pls_golite062009
oxidoreductase activity	0.459800433209317	bayes_pls_golite062009
transferase activity	0.413024577830522	bayes_pls_golite062009
binding	0.39163264055064	bayes_pls_golite062009
protein binding	0.149784186812647	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [680-857]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPLHVYYASD GGNAANLAKR LAARASARGL KATVLSMDDI ILEELPGEEN VVFITSTAGQ  60
   61 GEFPQDGKSF WEALKNDTDL DLASLNVAVF GLGDSEYWPR KEDKHYFNKP SQDLFKRLEL 120
  121 LSAKALIPLG LGDDQDADGF QTAYSEWEPK LWEALGVSGA AVDDEPKPVT NEDIKRES

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	191.9691
Match:	1b1cA_
Description:	NADPH-cytochrome p450 reductase, N-terminal domain
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.757525096811651	bayes_pls_golite062009
protein binding	0.398609344827318	bayes_pls_golite062009
catalytic activity	0.275631658558537	bayes_pls_golite062009

Predicted Domain #5

Region A:
Residues: [858-1117]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NFLRGTISEN LKDTSSGGVT HANEQLMKFH GIYTQDDRDI REIRKSQGLE PYYMFMARAR  60
   61 LPGGKTTPQQ WLALDHLSDT SGNGTLKLTT RATFQIHGVL KKNLKHTLRG MNAVLMDTLA 120
  121 AAGDVNRNVM VSALPTNAKV HQQIADMGKL ISDHFLPKTT AYHEVWLEGP EEQDDDPSWP 180
  181 SIFENRKDGP RKKKTLVSGN ALVDIEPIYG PTYLPRKFKF NIAVPPYNDV DVLSIDVGLV 240
  241 AIVNPETQIV EGYNVFVGGG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1131-1202]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGSCLGFVKT EDIIPPLEGI VIVQRDHGDR KDRKHARLKY TVDDMGVEGF KQKVEEYWGK  60
   61 KFEPERPFEF KS

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1386.0
Match:	1aop__
Description:	Sulfite reductase, domains 1 and 3; Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
Matching Structure (courtesy of the PDB):

Predicted Domain #6

Region A:
Residues: [1118-1130]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGTTHNNKKT YPR

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [1203-1442]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NIDYFGWIKD ETGLNHFTAF IENGRVEDTP DLPQKTGIRK VAEYMLKTNS GHFRLTGNQH  60
   61 LVISNITDEH VAGIKSILKT YKLDNTDFSG LRLSSSSCVG LPTCGLAFAE SERFLPDIIT 120
  121 QLEDCLEEYG LRHDSIIMRM TGCPNGCSRP WLGELALVGK APHTYNLMLG GGYLGQRLNK 180
  181 LYKANVKDEE IVDYIKPLFK RYALEREEGE HFGDFCIRVG IIKPTTEGKY FHEDVSEDAY 240
  241

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	1386.0
Match:	1aop__
Description:	Sulfite reductase, domains 1 and 3; Sulfite reductase hemoprotein (SiRHP), domains 2 and 4
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
sulfite reductase (NADPH) activity	10.5477019483845	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors	6.9484358652029	bayes_pls_golite062009
oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor	6.71341182064697	bayes_pls_golite062009
catalytic activity	1.39967796334655	bayes_pls_golite062009
binding	1.11461228884302	bayes_pls_golite062009
oxidoreductase activity	1.08956206944325	bayes_pls_golite062009
protein binding	0.618571973542447	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions:

Predicted functions: