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View Structure Prediction Details

Protein: DPO4_YEAST
Organism: Saccharomyces cerevisiae S288c
Length: 582 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for DPO4_YEAST.

Description E-value Query
Range
Subject
Range
POL4 - DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of...
DPO4_YEAST - DNA polymerase IV OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=POL4 PE=1 SV=4
0.0 [1..582] [1..582]
gi|112734841, gi... - gi|74137150|dbj|BAE21978.1| unnamed protein product [Mus musculus], gi|12802443|gb|AAK07885.1|AF3160...
0.0 [27..574] [13..509]
TDT_MONDO - DNA nucleotidylexotransferase OS=Monodelphis domestica GN=DNTT PE=2 SV=1
0.0 [27..574] [13..517]
TDT_BOVIN - DNA nucleotidylexotransferase (EC 2.7.7.31) (Terminal addition enzyme) (Terminal deoxynucleotidyltra...
0.0 [27..574] [24..519]
gi|7507776 - gi|7507776|pir||T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans
0.0 [27..574] [24..546]
gi|123981124, gi... - gi|123995939|gb|ABM85571.1| deoxynucleotidyltransferase, terminal [synthetic construct], gi|12398112...
DNTT - deoxynucleotidyltransferase, terminal
0.0 [27..574] [17..508]
TDT_XENLA - DNA nucleotidylexotransferase OS=Xenopus laevis GN=dntt PE=2 SV=1
0.0 [26..574] [12..506]

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Predicted Domain #1
Region A:
Residues: [1-91]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSLKGKFFAF LPNPNTSSNK FFKSILEKKG ATIVSSIQNC LQSSRKEVVI LIEDSFVDSD  60
   61 MHLTQKDIFQ REAGLNDVDE FLGKIEQSGI Q

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

    MCM
Score
GO
Score
GO
Term
SCOP
Match
SCOP Description
View Download 0.319 N/A N/A c.23.1 CheY-like
View Download 0.460 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.322 N/A N/A c.10.2 L domain-like
View Download 0.363 N/A N/A c.23.12 Formate/glycerate dehydrogenase catalytic domain-like
View Download 0.303 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.299 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.295 N/A N/A d.93.1 SH2 domain
View Download 0.280 N/A N/A d.68.3 SirA-like
View Download 0.269 N/A N/A c.47.1 Thioredoxin-like
View Download 0.260 N/A N/A d.58.34 Formiminotransferase domain of formiminotransferase-cyclodeaminase.
View Download 0.260 N/A N/A c.51.1 Anticodon-binding domain of Class II aaRS
View Download 0.255 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.253 N/A N/A a.77.1 DEATH domain
View Download 0.250 N/A N/A d.93.1 SH2 domain
View Download 0.235 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.228 N/A N/A d.113.1 Nudix
View Download 0.226 N/A N/A d.58.7 RNA-binding domain, RBD
View Download 0.224 N/A N/A d.58.5 GlnB-like
View Download 0.222 N/A N/A d.58.18 Regulatory domain in the aminoacid metabolism
View Download 0.219 N/A N/A d.58.3 Protease propeptides/inhibitors
View Download 0.215 N/A N/A c.58.1 Aminoacid dehydrogenase-like, N-terminal domain
View Download 0.210 N/A N/A d.58.12 eEF-1beta-like
View Download 0.207 N/A N/A d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.202 N/A N/A d.58.4 Dimeric alpha+beta barrel

Predicted Domain #2
Region A:
Residues: [92-149]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 CVKTSCITKW VQNDKFAFQK DDLIKFQPSI IVISDNADDG QSSTDKESEI STDVESER

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.575 d.58.17 Metal-binding domain
View Download 0.479 d.58.8 Viral DNA-binding domain
View Download 0.553 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.494 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.443 d.58.40 D-ribose-5-phosphate isomerase (RpiA), lid domain
View Download 0.431 d.58.17 Metal-binding domain
View Download 0.382 d.58.1 4Fe-4S ferredoxins
View Download 0.359 d.58.24 CheY-binding domain of CheA
View Download 0.343 d.58.5 GlnB-like
View Download 0.336 d.58.24 CheY-binding domain of CheA
View Download 0.307 d.58.17 Metal-binding domain
View Download 0.288 d.58.23 Probable ACP-binding domain of malonyl-CoA ACP transacylase
View Download 0.283 d.58.17 Metal-binding domain
View Download 0.266 d.52.3 Prokaryotic type KH domain (KH-domain type II)
View Download 0.238 d.58.3 Protease propeptides/inhibitors
View Download 0.225 g.3.11 EGF/Laminin
View Download 0.212 d.58.3 Protease propeptides/inhibitors
View Download 0.203 d.10.1 DNA-binding domain
View Download 0.202 d.74.1 Pterin-4a-carbinolamine dehydratase (PCD)/dimerization cofactor of HNF1 (DCoH)
View Download 0.201 d.45.1 ClpS-like

Predicted functions:

Term Confidence Notes
DNA polymerase activity 1.73758028049287 bayes_pls_golite062009
DNA-directed DNA polymerase activity 1.72676695496584 bayes_pls_golite062009
catalytic activity 0.60409960326459 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [150-264]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDDSNNKDMI QASKPLKRLL QGDKGRASLV TDKTKYKNNE LIIGALKRLT KKYEIEGEKF  60
   61 RARSYRLAKQ SMENCDFNVR SGEEAHTKLR NIGPSIAKKI QVILDTGVLP GLNDS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

Predicted Domain #4
Region A:
Residues: [265-318]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 VGLEDKLKYF KNCYGIGSEI AKRWNLLNFE SFCVAAKKDP EEFVSDWTIL FGWS

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

Predicted Domain #5
Region A:
Residues: [319-582]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YYDDWLCKMS RNECFTHLKK VQKALRGIDP ECQVELQGSY NRGYSKCGDI DLLFFKPFCN  60
   61 DTTELAKIME TLCIKLYKDG YIHCFLQLTP NLEKLFLKRI VERFRTAKIV GYGERKRWYS 120
  121 SEIIKKFFMG VKLSPRELEE LKEMKNDEGT LLIEEEEEEE TKLKPIDQYM SLNAKDGNYC 180
  181 RRLDFFCCKW DELGAGRIHY TGSKEYNRWI RILAAQKGFK LTQHGLFRNN ILLESFNERR 240
  241 IFELLNLKYA EPEHRNIEWE KKTA

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 216.0103
Match: 1jmsA_
Description: Terminal deoxynucleotidyl transferase
Matching Structure (courtesy of the PDB):

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle