YRC Public Data Repository - Protein Structure Prediction

Protein:	CBPS_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	576 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for CBPS_YEAST.

Description	E-value	Query Range	Subject Range
CBPS_YEAST - Carboxypeptidase S OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=CPS1 PE=1 SV=2 CPS1 - Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions	0.0	[1..576]	[1..576]
gi\|15620780 - gi\|15620780\|emb\|CAC69883.1\| glutamate carboxypeptidase [Homo sapiens]	2.0E-67	[79..575]	[7..473]
CNDP2_MOUSE - Cytosolic non-specific dipeptidase OS=Mus musculus GN=Cndp2 PE=1 SV=1	6.0E-66	[79..575]	[7..473]
YE48_SCHPO - Uncharacterized carboxypeptidase C24C9.08 OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=... SPAC24C9.08 - vacuolar carboxypeptidase	9.0E-66	[60..569]	[84..587]
pes-9 - Yeast hypothetical 52.9 KD protein like status:Confirmed UniProt:O18000 protein_id:CAB07646.1	2.0E-63	[75..574]	[4..472]
gi\|25520910 - pir\|\|G97371 argE/dapE/acy1 family protein [imported] - Agrobacterium tumefaciens (strain C58, Cereon... gi\|15154979, gi\|... - gi\|15887462\|ref\|NP_353143.1\| hypothetical protein AGR_C_165 [Agrobacterium tumefaciens str. C58], gi...	2.0E-61	[45..573]	[7..505]
gi\|15827662 - gi\|15827662\|ref\|NP_301925.1\| hypothetical protein ML1288 [Mycobacterium leprae TN] gi\|13093213, gi\|... - pir\|\|B87070 probable peptidase [imported] - Mycobacterium leprae, gi\|13093213\|emb\|CAC31669.1\| possib... gi\|221230139, gi... - gi\|221230139\|ref\|YP_002503555.1\| putative peptidase [Mycobacterium leprae Br4923], gi\|219933246\|emb\|...	4.0E-58	[87..569]	[31..464]

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Predicted Domain #1

Region A:
Residues: [1-68]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MIALPVEKAP RKSLWQRHRA FISGIVALII IGTFFLTSGL HPAPPHEAKR PHHGKGPMHS  60
   61 PKCEKIEP

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [69-291]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LSPSFKHSVD TILHDPAFRN SSIEKLSNAV RIPTVVQDKN PNPADDPDFY KHFYELHDYF  60
   61 EKTFPNIHKH LKLEKVNELG LLYTWEGSDP DLKPLLLMAH QDVVPVNNET LSSWKFPPFS 120
  121 GHYDPETDFV WGRGSNDCKN LLIAEFEAIE QLLIDGFKPN RTIVMSLGFD EEASGTLGAA 180
  181 SLASFLHERY GDDGIYSIID EGEGIMEVDK DVFVATPINA EKG

[Run NCBI BLAST on this sequence.]

Region B:
Residues: [401-479]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GVKANALPET TRFLINHRIN LHSSVAEVFE RNIEYAKKIA EKYGYGLSKN GDDYIIPETE  60
   61 LGHIDITLLR ELEPAPLSP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	4.61719816036179	bayes_pls_golite062009
peptidase activity	4.41512153958838	bayes_pls_golite062009
peptidase activity, acting on L-amino acid peptides	3.59809762149163	bayes_pls_golite062009
catalytic activity	2.00064748759729	bayes_pls_golite062009
exopeptidase activity	0.906571162336786	bayes_pls_golite062009
binding	0.767655217795721	bayes_pls_golite062009
endopeptidase activity	0.529831416345723	bayes_pls_golite062009
carboxypeptidase activity	0.389857234977383	bayes_pls_golite062009

Predicted Domain #3

Region A:
Residues: [292-400]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 YVDFEVSILG HGGHSSVPPD HTTIGIASEL ITEFEANPFD YEFEFDNPIY GLLTCAAEHS  60
   61 KSLSKDVKKT ILGAPFCPRR KDKLVEYISN QSHLRSLIRT TQAVDIING

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	32.0
Match:	1cg2A_
Description:	Carboxypeptidase G2, catalytic domain; Carboxypeptidase G2
Matching Structure (courtesy of the PDB):

Predicted Domain #4

Region A:
Residues: [480-576]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSGPVWDILA GTIQDVFENG VLQNNEEFYV TTGLFSGNTD TKYYWNLSKN IYRFVGSIID  60
   61 IDLLKTLHSV NEHVDVPGHL SAIAFVYEYI VNVNEYA

[Run NCBI BLAST on this sequence.]

Detection Method:	ORFEUS
Confidence:	7.46
Match:	1lfwA
Description:	Aminopeptidase PepV
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: