YRC Public Data Repository - Protein Structure Prediction

Protein:	RSMA_BRUME
Organism:	Brucella melitensis bv. 1 str. 16M
Length:	276 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for RSMA_BRUME.

Description	E-value	Query Range	Subject Range
gi\|254717135 - gi\|254717135\|ref\|ZP_05178946.1\| dimethyladenosine transferase [Brucella ceti M13/05/1] gi\|254729984 - gi\|254729984\|ref\|ZP_05188562.1\| dimethyladenosine transferase [Brucella abortus bv. 4 str. 292] RSMA_BRUSU - Ribosomal RNA small subunit methyltransferase A OS=Brucella suis biovar 1 (strain 1330) GN=rsmA PE=3... RSMA_BRUA1 - Ribosomal RNA small subunit methyltransferase A OS=Brucella abortus (strain S19) GN=rsmA PE=3 SV=1 RSMA_BRUA2 - Ribosomal RNA small subunit methyltransferase A OS=Brucella abortus (strain 2308) GN=rsmA PE=3 SV=1 RSMA_BRUMB - Ribosomal RNA small subunit methyltransferase A OS=Brucella melitensis biotype 2 (strain ATCC 23457)... gi\|237815135, gi... - gi\|237815135\|ref\|ZP_04594133.1\| dimethyladenosine transferase [Brucella abortus str. 2308 A], gi\|237... gi\|225627179, gi... - gi\|225627179\|ref\|ZP_03785217.1\| dimethyladenosine transferase [Brucella ceti str. Cudo], gi\|22561801... gi\|254697088 - gi\|254697088\|ref\|ZP_05158916.1\| dimethyladenosine transferase [Brucella abortus bv. 2 str. 86/8/59] RSMA_BRUSU, KSGA... - Ribosomal RNA small subunit methyltransferase A OS=Brucella suis GN=rsmA PE=3 SV=1, Dimethyladenosin... gi\|254701465 - gi\|254701465\|ref\|ZP_05163293.1\| dimethyladenosine transferase [Brucella suis bv. 5 str. 513] RSMA_BRUO2 - Ribosomal RNA small subunit methyltransferase A OS=Brucella ovis (strain ATCC 25840 / 63/290 / NCTC ... gi\|254688954 - gi\|254688954\|ref\|ZP_05152208.1\| dimethyladenosine transferase [Brucella abortus bv. 6 str. 870] gi\|254693436 - gi\|254693436\|ref\|ZP_05155264.1\| dimethyladenosine transferase [Brucella abortus bv. 3 str. Tulya] gi\|82615673 - gi\|82615673\|emb\|CAJ10660.1\| SAM (and some other nucleotide) binding motif:Ribosomal RNA adenine dime... gi\|254709803 - gi\|254709803\|ref\|ZP_05171614.1\| dimethyladenosine transferase [Brucella pinnipedialis B2/94] RSMA_BRUC2 - Ribosomal RNA small subunit methyltransferase A OS=Brucella canis (strain ATCC 23365 / NCTC 10854) G... gi\|254713807 - gi\|254713807\|ref\|ZP_05175618.1\| dimethyladenosine transferase [Brucella ceti M644/93/1] gi\|254704012 - gi\|254704012\|ref\|ZP_05165840.1\| dimethyladenosine transferase [Brucella suis bv. 3 str. 686] gi\|254707614 - gi\|254707614\|ref\|ZP_05169442.1\| dimethyladenosine transferase [Brucella pinnipedialis M163/99/10]	245.0	[0..1]	[276..1]
RSMA_BRUAB - Ribosomal RNA small subunit methyltransferase A OS=Brucella abortus biovar 1 (strain 9-941) GN=rsmA ... RSMA_BRUAB, KSGA... - Ribosomal RNA small subunit methyltransferase A OS=Brucella abortus GN=rsmA PE=3 SV=1, Dimethyladeno...	245.0	[0..1]	[276..1]
RSMA_CHESB - Ribosomal RNA small subunit methyltransferase A OS=Chelativorans sp. (strain BNC1) GN=rsmA PE=3 SV=1	239.0	[0..1]	[274..1]
gi\|25286079, gi\|... - gi\|25286080\|pir\|\|AF2712 rRNA-adenine N6,N6-dimethyltransferase [imported] - Agrobacterium tumefacien... RSMA_AGRFC - Ribosomal RNA small subunit methyltransferase A OS=Agrobacterium fabrum (strain C58 / ATCC 33970) GN...	236.0	[0..2]	[274..3]
RSMA_RHILO - Ribosomal RNA small subunit methyltransferase A OS=Rhizobium loti (strain MAFF303099) GN=rsmA PE=3 S... KSGA_RHILO, RSMA... - Ribosomal RNA small subunit methyltransferase A OS=Rhizobium loti GN=rsmA PE=3 SV=1, Dimethyladenosi...	230.0	[0..1]	[273..1]
RSMA_SINMW - Ribosomal RNA small subunit methyltransferase A OS=Sinorhizobium medicae (strain WSM419) GN=rsmA PE=...	229.0	[0..2]	[274..3]
KSGA_RHIME, RSMA... - Ribosomal RNA small subunit methyltransferase A OS=Rhizobium meliloti GN=rsmA PE=3 SV=1, Dimethylade... RSMA_RHIME - Ribosomal RNA small subunit methyltransferase A OS=Rhizobium meliloti (strain 1021) GN=rsmA PE=3 SV=...	225.0	[0..2]	[274..3]
RSMA_RHIL3 - Ribosomal RNA small subunit methyltransferase A OS=Rhizobium leguminosarum bv. viciae (strain 3841) ...	224.0	[0..2]	[274..3]
gi\|90336434, gi\|... - gi\|90419497\|ref\|ZP_01227407.1\| dimethyladenosine transferase [Aurantimonas sp. SI85-9A1], gi\|9033643... gi\|90336434, gi\|... - gi\|90419497\|ref\|ZP_01227407.1\| dimethyladenosine transferase [Aurantimonas sp. SI85-9A1], gi\|9033643...	224.0	[0..2]	[274..3]
RSMA_BARHE, KSGA... - Ribosomal RNA small subunit methyltransferase A OS=Bartonella henselae GN=rsmA PE=3 SV=1, Dimethylad... RSMA_BARHE - Ribosomal RNA small subunit methyltransferase A OS=Bartonella henselae (strain ATCC 49882 / DSM 2822...	222.0	[0..1]	[273..1]

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Predicted Domain #1

Region A:
Residues: [1-276]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIDSLPPLR EVIERHDLMP KKSLGQNFLF DLNLTSKIAR QAGDLRDQPV IEVGPGPGGL  60
   61 TRALLAQGAY VTAIERDDRC LEALAEIAAH YPGRLRIIAG DALEQDFTAL FPEGPKPRIV 120
  121 ANLPYNVGTQ LLLNWLLVEP WPPFYSSMTL MFQREVAERI VAKLDSDHYG RLGVLAGWRT 180
  181 QAKIAFDVPP QAFTPPPKVM SSVVHIVPRE TPLPCRAEAL GQITQAAFGQ RRKMLRQSLK 240
  241 SIGGAALLEK TGIDGTRRAE TLSVEEFVAL ANACLP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	47.045757
Match:	1qyrA
Description:	2.1 Angstrom Crystal structure of KsgA: A Universally Conserved Adenosine Dimethyltransferase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
methyltransferase activity	4.15445027778357	bayes_pls_golite062009
rRNA methyltransferase activity	4.09362182773099	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	4.07153733729662	bayes_pls_golite062009
N-methyltransferase activity	3.67177992319602	bayes_pls_golite062009
protein methyltransferase activity	3.5512266163483	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	3.39429041855776	bayes_pls_golite062009
RNA methyltransferase activity	3.07428840534971	bayes_pls_golite062009
histone methyltransferase activity	2.49492581548369	bayes_pls_golite062009
transferase activity	2.22303238506686	bayes_pls_golite062009
DNA-methyltransferase activity	2.14498896320526	bayes_pls_golite062009
protein-arginine N-methyltransferase activity	2.06652984530965	bayes_pls_golite062009
arginine N-methyltransferase activity	2.06652984530965	bayes_pls_golite062009
rRNA (adenine) methyltransferase activity	1.83964463328968	bayes_pls_golite062009
rRNA (adenine-N6,N6-)-dimethyltransferase activity	1.75675289134467	bayes_pls_golite062009
histone-arginine N-methyltransferase activity	1.63076727020333	bayes_pls_golite062009
transcription regulator activity	1.42049721553167	bayes_pls_golite062009
protein-arginine omega-N monomethyltransferase activity	1.26493190370687	bayes_pls_golite062009
catalytic activity	1.25333584501255	bayes_pls_golite062009
tRNA methyltransferase activity	1.12859857407629	bayes_pls_golite062009
rRNA (guanine) methyltransferase activity	1.10713374933008	bayes_pls_golite062009
DNA binding	1.03011331296251	bayes_pls_golite062009
nucleic acid binding	0.731396842794323	bayes_pls_golite062009
histone methyltransferase activity (H4-R3 specific)	0.720411427168235	bayes_pls_golite062009
site-specific DNA-methyltransferase (adenine-specific) activity	0.703178429468566	bayes_pls_golite062009
protein-arginine omega-N asymmetric methyltransferase activity	0.606920378432989	bayes_pls_golite062009
binding	0.546744797014504	bayes_pls_golite062009
mitochondrial transcription initiation factor activity	0.481383105532041	bayes_pls_golite062009
tRNA (cytosine-5-)-methyltransferase activity	0.299393192819978	bayes_pls_golite062009
tRNA (cytosine)-methyltransferase activity	0.299393192819978	bayes_pls_golite062009
rRNA (guanine-N1-)-methyltransferase activity	0.234572322347698	bayes_pls_golite062009
rRNA (uridine-2'-O-)-methyltransferase activity	0.188049877065151	bayes_pls_golite062009
transcription factor binding	0.149382105526243	bayes_pls_golite062009
rRNA (uridine) methyltransferase activity	0.130647573658872	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: