YRC Public Data Repository - Protein Structure Prediction

Protein:	STP22_YEAST
Organism:	Saccharomyces cerevisiae S288c
Length:	385 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for STP22_YEAST.

Description	E-value	Query Range	Subject Range
STP22 - Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into ... gi\|190406431 - gi\|190406431\|gb\|EDV09698.1\| hypothetical protein SCRG_05394 [Saccharomyces cerevisiae RM11-1a] gi\|207347351 - gi\|207347351\|gb\|EDZ73550.1\| YCL008Cp-like protein [Saccharomyces cerevisiae AWRI1631] STP22_YEAST - Suppressor protein STP22 of temperature-sensitive alpha-factor receptor and arginine permease OS=Sac...	5.0E-97	[1..385]	[1..385]
gi\|45361377, gi\|... - gi\|89271346\|emb\|CAJ83421.1\| tumor susceptibility gene 101 [Xenopus tropicalis], gi\|45361377\|ref\|NP_9...	9.0E-79	[21..379]	[11..384]
gi\|46249848, gi\|... - gi\|46249848\|gb\|AAH68660.1\| MGC81040 protein [Xenopus laevis], gi\|147905306\|ref\|NP_001084620.1\| hypot...	2.0E-77	[21..379]	[11..383]
TS101_MOUSE - Tumor susceptibility gene 101 protein OS=Mus musculus GN=Tsg101 PE=1 SV=2	2.0E-77	[21..379]	[11..380]
gi\|114636476 - gi\|114636476\|ref\|XP_001173373.1\| PREDICTED: tumor susceptibility gene 101 isoform 1 [Pan troglodytes... TSG101 - tumor susceptibility gene 101 gi\|60813968, gi\|... - gi\|61355217\|gb\|AAX41115.1\| tumor susceptibility gene 101 [synthetic construct], gi\|60813968\|gb\|AAX36...	5.0E-77	[21..379]	[11..379]
gi\|9454364 - gi\|9454364\|gb\|AAF87776.1\| tumor susceptibility protein 101 [Chelonia mydas]	1.0E-76	[21..379]	[11..381]
TSG101-PA - The gene tumor suppressor protein 101 is referred to in FlyBase by the symbol Dmel\TSG101 (CG9712, F...	2.0E-63	[22..379]	[13..399]
tsg-101 - status:Partially_confirmed UniProt:O76258 protein_id:AAC25822.2	2.0E-63	[26..379]	[16..416]
gi\|44980427 - gi\|44980427\|gb\|AAS50360.1\| AAL006Cp [Ashbya gossypii ATCC 10895] gi\|45184818, gi\|... - gi\|45184818\|ref\|NP_982536.1\| AAL006Cp [Ashbya gossypii ATCC 10895], gi\|44980427\|gb\|AAS50360.1\| AAL00...	2.0E-62	[3..380]	[4..439]

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Predicted Domain #1

Region A:
Residues: [1-233]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSANGKISVP EAVVNWLFKV IQPIYNDGRT TFHDSLALLD NFHSLRPRTR VFTHSDGTPQ  60
   61 LLLSIYGTIS TGEDGSSPHS IPVIMWVPSM YPVKPPFISI NLENFDMNTI SSSLPIQEYI 120
  121 DSNGWIALPI LHCWDPAAMN LIMVVQELMS LLHEPPQDQA PSLPPKPNTQ LQQEQNTPPL 180
  181 PPKPKSPHLK PPLPPPPPPQ PASNALDLMD MDNTDISPTN HHEMLQNLQT VVN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	35.69897
Match:	1uzxA_
Description:	A complex of the Vps23 UEV with ubiquitin
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
small conjugating protein ligase activity	5.39546375801135	bayes_pls_golite062009
ubiquitin-protein ligase activity	5.24355531841986	bayes_pls_golite062009
acid-amino acid ligase activity	4.3569172339832	bayes_pls_golite062009
ligase activity, forming carbon-nitrogen bonds	2.17039194032383	bayes_pls_golite062009
ligase activity	1.88059319399119	bayes_pls_golite062009
protein binding	1.12473783261956	bayes_pls_golite062009
catalytic activity	0.891402822028799	bayes_pls_golite062009
binding	0.7313332818323	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [234-385]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 ELYREDVDYV ADKILTRQTV MQESIARFHE IIAIDKNHLR AVEQAIEQTM HSLNAQIDVL  60
   61 TANRAKVQQF SSTSHVDDED VNSIAVAKTD GLNQLYNLVA QDYALTDTIE CLSRMLHRGT 120
  121 IPLDTFVKQG RELARQQFLV RWHIQRITSP LS

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: