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View Structure Prediction Details

Protein: gi|3451474, gi|1...
Organism: Schizosaccharomyces pombe
Length: 628 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|3451474, gi|1....

Description E-value Query
Range
Subject
Range
gi|34866283, gi|... - ref|XP_345697.1| similar to Ac2-155 [Rattus norvegicus], gi|109478405|ref|XP_001055909.1| PREDICTED:...
665.0 [0..2] [609..35]
CWC22_MOUSE - Pre-mRNA-splicing factor CWC22 homolog OS=Mus musculus GN=Cwc22 PE=1 SV=1
664.0 [0..2] [609..34]
gi|71051531 - gi|71051531|gb|AAH31216.1| CWC22 protein [Homo sapiens]
657.0 [0..2] [609..35]
cwf22 - splicing factor Cwf22
656.0 [0..1] [627..1]

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Predicted Domain #1
Region A:
Residues: [1-90]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEKEDKSFGI GMLDYNRENP ESSGHSRVAV IRKQKTEQEN NNLSWEDRHY IPDLHKSNKI  60
   61 KTPTSLADEK KSHNELDPKA QIKKLMETRS 

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [91-331]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 GGTYIPPAKL KALQAQLTDV NTPEYQRMQW EALKKSINGL INKVNKSNIR DIIPELFQEN  60
   61 IIRGRALYCR SIMKAQAASL PFTPIYAAMT AVINTKFPQI GELLLTRLIV QFRKSFQRND 120
  121 KSMCISSSSF IAHLINQKIA HEIVGLQILA VLLERPTNDS IEIAVMLLRE IGAYLAEVST 180
  181 RAYNGVFERF RTILHEGQLE RRTQFIIEVL FQTRKDKFKN NPTIPQELDL VEEEDQITHY 240
  241 I

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 49.39794
Match: 1hu3A
Description: Eukaryotic initiation factor eIF4G
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.20683443264388 bayes_pls_golite062009
mRNA binding 2.49094746544717 bayes_pls_golite062009
binding 2.47395644967726 bayes_pls_golite062009
nucleic acid binding 1.64539435934931 bayes_pls_golite062009
structural molecule activity 1.39201458088376 bayes_pls_golite062009
transcription regulator activity 1.06250847754412 bayes_pls_golite062009
protein binding 1.04044934052933 bayes_pls_golite062009
DNA binding 0.946847037737779 bayes_pls_golite062009
RNA cap binding 0.66277586901495 bayes_pls_golite062009
transcription factor activity 0.362911773502049 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [332-628]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SLDDNLDVQE SLGIFHYDPD YEENEKKYDA IKHEILGEED DDENEEDEED SEETSESEED  60
   61 ESVNDEKPQV IDQTNASLVN LRKSIYLTIM SSVDFEECCH KLLKIDLPEG QEIELCNMVI 120
  121 ECNSQERTYA KFYGLIGERF CKLSRTWRST YEQCFKNYYE TIHRYETNRL RNIALFFANL 180
  181 LSTDSIGWEV YDCVRLTEDD TTASSRIFLK IMFQEIVEAL GLKSLVERLH DPNLVPYLHG 240
  241 LFPVDEARNV RFSINYFTSI GLGALTEEMR EYLLTMPKSE PKEQDSEGYS SGSETGS

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.68
Match: 1n52A
Description: CBP80, 80KDa nuclear cap-binding protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.05046860305563 bayes_pls_golite062009
binding 2.36800795249393 bayes_pls_golite062009
mRNA binding 2.35042158577052 bayes_pls_golite062009
nucleic acid binding 1.59410102249793 bayes_pls_golite062009
structural molecule activity 1.3916221897201 bayes_pls_golite062009
transcription regulator activity 1.08645493064764 bayes_pls_golite062009
DNA binding 0.956143892328242 bayes_pls_golite062009
protein binding 0.914877292844892 bayes_pls_golite062009
transcription factor activity 0.371244009721798 bayes_pls_golite062009
RNA cap binding 0.357520253345298 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle