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View Structure Prediction Details

Protein: LRP6A_ARATH
Organism: Arabidopsis thaliana
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LRP6A_ARATH.

Description E-value Query
Range
Subject
Range
gi|55959639, gi|... - gi|66267552|gb|AAH94755.1| PABPC4 protein [Homo sapiens], gi|55962217|emb|CAI12298.1| poly(A) bindin...
gi|114555673 - gi|114555673|ref|XP_001170937.1| PREDICTED: poly A binding protein, cytoplasmic 4 isoform 1 [Pan tro...
272.0 [0..30] [422..129]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLPLRSGE KMESPSISDA VPLHAPEDAT ADFSQPQSPL HEVDSFPVTE SSDDVVVNVS  60
   61 EIPNLSPSDD DFDHERNSGE DRDQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGENPVETDG VVVPIDELNQ KIIRQVEYYF SDENLPTDKF LLNAMKRNKK GFVPISTIAT  60
   61 FHKMKKLTRD HALIVSALKE SSFLVVSADE KKVKRLSPLP EIRDPKIFTV LVENLPEDHS 120
  121 NENIREIFGK AGSIKSVSIC DPNAVEESEK GGKKENFIRT RLHAFVEYET VEAAEKAAAT 180
  181 LNNEQDWRNG LRVKLLEQAA G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.39794
Match: 1po6A
Description: Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.46119712758726 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
mRNA binding 3.05425904007847 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
1.52879236550095 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
single-stranded RNA binding 0.852368751354665 bayes_pls_golite062009
ligase activity 0.633198446266208 bayes_pls_golite062009
poly-pyrimidine tract binding 0.56829350502235 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [287-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFAQRRPARR EVDKEKDTTG RVHDQTGGEK NKKTREHQNH RLHHSDNPAD DDGGNHQKDK  60
   61 NGNKGRVVGQ GRRQNHQGGN GIGHGTASSS SHPNYHPVEV SKRPPGPRMP DGTRGFTMGR 120
  121 GKAIPPPTST QTSHEV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle