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View Structure Prediction Details

Protein: LRP6A_ARATH
Organism: Arabidopsis thaliana
Length: 422 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for LRP6A_ARATH.

Description E-value Query
Range
Subject
Range
gi|55959639, gi|... - gi|66267552|gb|AAH94755.1| PABPC4 protein [Homo sapiens], gi|55962217|emb|CAI12298.1| poly(A) bindin...
gi|114555673 - gi|114555673|ref|XP_001170937.1| PREDICTED: poly A binding protein, cytoplasmic 4 isoform 1 [Pan tro...
272.0 [0..30] [422..129]

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Predicted Domain #1
Region A:
Residues: [1-85]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSLPLRSGE KMESPSISDA VPLHAPEDAT ADFSQPQSPL HEVDSFPVTE SSDDVVVNVS  60
   61 EIPNLSPSDD DFDHERNSGE DRDQD

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #2
Region A:
Residues: [86-286]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 HGENPVETDG VVVPIDELNQ KIIRQVEYYF SDENLPTDKF LLNAMKRNKK GFVPISTIAT  60
   61 FHKMKKLTRD HALIVSALKE SSFLVVSADE KKVKRLSPLP EIRDPKIFTV LVENLPEDHS 120
  121 NENIREIFGK AGSIKSVSIC DPNAVEESEK GGKKENFIRT RLHAFVEYET VEAAEKAAAT 180
  181 LNNEQDWRNG LRVKLLEQAA G

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 39.39794
Match: 1po6A
Description: Crystal Structure of UP1 Complexed With d(TAGG(6MI)TTAGGG): A Human Telomeric Repeat Containing 6-methyl-8-(2-deoxy-beta-ribofuranosyl)isoxanthopteridine (6MI)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
RNA binding 4.46119712758726 bayes_pls_golite062009
nucleic acid binding 3.81920018903278 bayes_pls_golite062009
mRNA binding 3.05425904007847 bayes_pls_golite062009
binding 3.05116833253954 bayes_pls_golite062009
1.52879236550095 bayes_pls_golite062009
transcription regulator activity 1.07788694919471 bayes_pls_golite062009
DNA binding 0.978604858165557 bayes_pls_golite062009
single-stranded RNA binding 0.852368751354665 bayes_pls_golite062009
ligase activity 0.633198446266208 bayes_pls_golite062009
poly-pyrimidine tract binding 0.56829350502235 bayes_pls_golite062009
protein binding 0.42571879933058 bayes_pls_golite062009
transcription factor activity 0.234742017105535 bayes_pls_golite062009

Predicted Domain #3
Region A:
Residues: [287-422]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KFAQRRPARR EVDKEKDTTG RVHDQTGGEK NKKTREHQNH RLHHSDNPAD DDGGNHQKDK  60
   61 NGNKGRVVGQ GRRQNHQGGN GIGHGTASSS SHPNYHPVEV SKRPPGPRMP DGTRGFTMGR 120
  121 GKAIPPPTST QTSHEV

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below are all of our structure predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.


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