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View Structure Prediction Details

Protein: gi|254684127
Organism: Bacillus anthracis str. CNEVA-9066
Length: 867 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|254684127.

Description E-value Query
Range
Subject
Range
gi|42739428, gi|... - gi|42783499|ref|NP_980746.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus AT...
0.0 [1..867] [1..867]
gi|49476825, gi|... - gi|49476825|ref|YP_038422.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus thuringie...
0.0 [15..867] [15..867]
gi|30022446, gi|... - gi|30022446|ref|NP_834077.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus AT...
gi|228653768, gi... - gi|229129651|ref|ZP_04258619.1| Alcohol dehydrogenase, iron-containing [Bacillus cereus BDRD-Cer4], ...
0.0 [18..867] [18..867]
gi|51974605, gi|... - gi|52141136|ref|YP_085694.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus cereus E3...
0.0 [15..867] [15..867]
gi|114845300, gi... - gi|167039286|ref|YP_001662271.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Thermoanaeroba...
0.0 [15..864] [24..870]
gi|241903602, gi... - gi|241903602|ref|ZP_04788323.1| iron-containing alcohol dehydrogenase [Thermoanaerobacter brockii su...
gi|76588428, gi|... - gi|76796158|ref|ZP_00778525.1| Iron-containing alcohol dehydrogenase [Thermoanaerobacter ethanolicus...
0.0 [15..864] [24..870]
gi|52005783, gi|... - gi|52787967|ref|YP_093796.1| bifunctional acetaldehyde-CoA/alcohol dehydrogenase [Bacillus lichenifo...
0.0 [18..866] [18..866]
gi|111143367 - gi|111143367|gb|ABH06551.1| alcohol/aldehyde dehydrogenase [Thermoanaerobacter ethanolicus]
0.0 [17..864] [26..872]
gi|89210581, gi|... - gi|89210581|ref|ZP_01188969.1| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Halothe...
0.0 [15..866] [27..875]
gi|163942121, gi... - gi|89206333|ref|ZP_01184893.1| Iron-containing alcohol dehydrogenase:Aldehyde dehydrogenase [Bacillu...
0.0 [15..866] [15..866]

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Predicted Domain #1
Region A:
Residues: [1-455]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVVKEKVVNE MQEVKEMIDT LVNNGRKALQ ALESFTQEQI DNIVHEMALA GVDQHMPLAK  60
   61 LAVEETGRGV YEDKCIKNIF ATEYIWHSIK KDKTVGIIHE DPHEEIIEIA EPVGVVAGVT 120
  121 PVTNPTSTTM FKALIAIKTR NPIIFAFHPS AQNCSVAAAK TVYDAAVKAG APKHCIQWIE 180
  181 KPSVEATKQL MNHEGVALVL ATGGAGMVKS AYSTGKPALG VGPGNVPCYI EKSAHIKRAV 240
  241 NDLILSKTFD NGMICASEQA IIVDKEIYDD VKTEMITNDC YFVTEEERRK LEKLVINENT 300
  301 CAVNSDIVGK SAQYIAELVG ITVPKNTKML VAEIQGIGAA YPLSREKLSP VLACVKANSL 360
  361 EEGFTYCEEM LNLGGLGHSA VIHSVNKEVQ KQFGLRMKAC RLIVNAPSSQ GGIGDIYNGF 420
  421 IPSLTLGCGS YGKNSVSQNV TATHLLNIKR LANRK

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 139.0
Match: 1bxsA
Description: Aldehyde reductase (dehydrogenase), ALDH
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
oxidoreductase activity 4.47226217021998 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 4.34495776828926 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 3.37049090049734 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase [NAD(P)+] activity 3.30681232755737 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor 3.2867555127991 bayes_pls_golite062009
aldehyde dehydrogenase (NAD) activity 2.81851373615334 bayes_pls_golite062009
catalytic activity 2.80804701752928 bayes_pls_golite062009
succinate-semialdehyde dehydrogenase activity 2.25908515251731 bayes_pls_golite062009
benzaldehyde dehydrogenase activity 1.80313175632526 bayes_pls_golite062009
methylmalonate-semialdehyde dehydrogenase (acylating) activity 1.59279206536309 bayes_pls_golite062009
1-pyrroline-5-carboxylate dehydrogenase activity 1.15620590715864 bayes_pls_golite062009
binding 0.637403449596354 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [456-867]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 KNMQWFKLPP KIYFEKHATA YLANMPNISR AFIVTDPGMV EHGYVDTVAH YLRKHANDVK  60
   61 VEVFFEVEPD PSDETVFKGA EMMRSFQPDV IIALGGGSAM DAAKGMWLFY EYPETTFYGI 120
  121 KQKFLDIRKR TCKYPELGSK AQFVAIPTTS GTGSEVTPFA VITDKKNNIK YPLADYELTP 180
  181 DVAIVDPQFV MTVPPHVTAD TGMDVLTHAI EAYVSVLAND YTDGLALKAI DLVFKYLPRA 240
  241 FKDGHDEEAR EKMHNASAIA GMAFANAFLG INHSLAHKIG PEFHIPHGRA NAILMPHVIR 300
  301 YNAIKPRKHA LFPKYEHFVA DERYAHIARM LGLPASSVAE GVESLDKAII DLGKSLNINM 360
  361 SIAGQGVAKD QFEEVVGLLA ERAFEDQCTT ANPKLPLISE LKEIYMKAYK GE

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 91.30103
Match: 1rrmA
Description: Crystal Structure of Lactaldehyde reductase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
hydroxyacid-oxoacid transhydrogenase activity 8.51876704052427 bayes_pls_golite062009
alcohol dehydrogenase (NAD) activity 5.26400058766942 bayes_pls_golite062009
oxidoreductase activity 3.07409531087588 bayes_pls_golite062009
alcohol dehydrogenase activity, metal ion-independent 3.05722501802075 bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors 2.83823088483915 bayes_pls_golite062009
catalytic activity 2.37357608468991 bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor 2.10085302216488 bayes_pls_golite062009
binding 1.15096180564234 bayes_pls_golite062009
3-chloroallyl aldehyde dehydrogenase activity 0.831155115586418 bayes_pls_golite062009
cation binding 0.319000821544479 bayes_pls_golite062009
metal ion binding 0.319000821544479 bayes_pls_golite062009
ion binding 0.313606245452103 bayes_pls_golite062009
protein binding 0.295023706645045 bayes_pls_golite062009
transition metal ion binding 0.259889634539407 bayes_pls_golite062009
oxidoreductase activity, acting on the aldehyde or oxo group of donors 0.0904828025133766 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle