YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|229546825, gi...
Organism:	Enterococcus faecalis TX1322
Length:	281 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|229546825, gi....

Description	E-value	Query Range	Subject Range
FOLD_MOOTA - Bifunctional protein FolD OS=Moorella thermoacetica (strain ATCC 39073) GN=folD PE=3 SV=1	418.0	[0..2]	[279..3]
FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD... sp\|A0LE04\|FOLD_MAGMM - Bifunctional protein FolD OS=Magnetococcus marinus (strain ATCC BAA-1437 / JCM 17883 / MC-1) GN=folD...	416.0	[0..1]	[279..1]
FOLD_BORA1 - Bifunctional protein FolD OS=Bordetella avium (strain 197N) GN=folD PE=3 SV=1	405.0	[0..2]	[279..3]
FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis (strain 168) GN=folD PE=3 SV=1 FOLD_BACSU - Bifunctional protein FolD OS=Bacillus subtilis GN=folD PE=3 SV=1 gi\|221323877 - gi\|221323877\|ref\|ZP_03605171.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221319601 - gi\|221319601\|ref\|ZP_03600895.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su... gi\|221314678 - gi\|221314678\|ref\|ZP_03596483.1\| methenyltetrahydrofolate cyclohydrolase [Bacillus subtilis subsp. su...	404.0	[0..2]	[279..3]
gi\|37958858 - gi\|37958858\|gb\|AAP51122.1\| putative methylenetetrahydrofolate dehydrogenase [uncultured bacterium]	404.0	[0..2]	[279..3]
gi\|67153449 - gi\|67153449\|ref\|ZP_00415194.1\| Methenyltetrahydrofolate cyclohydrolase [Azotobacter vinelandii AvOP] FOLD_AZOVD - Bifunctional protein FolD OS=Azotobacter vinelandii (strain DJ / ATCC BAA-1303) GN=folD PE=3 SV=1	404.0	[0..2]	[279..3]
gi\|77172056, gi\|... - gi\|77409324\|ref\|ZP_00786027.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|76585577, gi\|... - gi\|76799062\|ref\|ZP_00781254.1\| methenyltetrahydrofolate cyclohydrolase folD [Streptococcus agalacti... FOLD_STRA5 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype V GN=folD PE=3 SV=1 FOLD_STRA3 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype III GN=folD PE=3 SV=1 FOLD_STRA1 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype Ia GN=folD PE=3 SV=1 FOLD_STRA3 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype III (strain NEM316) GN=folD PE=3 SV=1 FOLD_STRA1 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype Ia (strain ATCC 27591 / A909 / CDC SS... FOLD_STRA5 - Bifunctional protein FolD OS=Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) GN... gi\|77405305, gi\|... - gi\|77405305\|ref\|ZP_00782401.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|77159936, gi\|... - gi\|77414010\|ref\|ZP_00790182.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl... gi\|77412380, gi\|... - gi\|77412380\|ref\|ZP_00788690.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycl...	404.0	[0..1]	[279..1]
FOLD_STRPN - Bifunctional protein FolD OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=fo... FOLD_STRPN - Bifunctional protein FolD OS=Streptococcus pneumoniae GN=folD PE=3 SV=1	403.0	[0..1]	[279..1]
gi\|15458321, gi\|... - gi\|15902773\|ref\|NP_358323.1\| methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cycloh... gi\|25284854 - pir\|\|A97963 methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9) folD [imported] - Streptococcus pne...	402.0	[0..1]	[279..22]
FOLD_PASMU - Bifunctional protein folD OS=Pasteurella multocida GN=folD PE=3 SV=1 FOLD_PASMU - Bifunctional protein FolD OS=Pasteurella multocida (strain Pm70) GN=folD PE=3 SV=1	402.0	[0..2]	[280..3]

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Predicted Domain #1

Region A:
Residues: [1-281]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSTVINGREL ADQMQAEIQK DVEKMTQQGI QPGLVVLLVG ENPASQTYVR NKERAAAKIG  60
   61 ILSKVEKLPE TISEEELLAE IDKYNQDSRF HGILVQLPLP KHIDEEKILL AIDPKKDVDG 120
  121 FHPMNLGRLF VGKPEMIPCT PYGIMKMFEA YDIDLTGKRA VVIGRSNIVG KPMAQLLLMK 180
  181 NATVTIAHSK TEHLAEVAKE ADILVVAIGR GHFVTKEFVK PGAVVIDVGM NRNQEGKLIG 240
  241 DVAFDEVSEI ASYITPVPKG VGPMTITMLM YQTVEAAKKQ K

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	109.0
Match:	1b0aA
Description:	Methylenetetrahydrofolate dehydrogenase/cyclohydrolase; Tetrahydrofolate dehydrogenase/cyclohydrolase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
oxidoreductase activity	3.54983447672782	bayes_pls_golite062009
oxidoreductase activity, acting on CH-OH group of donors	2.66605122152932	bayes_pls_golite062009
malate dehydrogenase activity	2.43636049081724	bayes_pls_golite062009
catalytic activity	2.0643953589843	bayes_pls_golite062009
transcription regulator activity	1.95832530533882	bayes_pls_golite062009
methenyltetrahydrofolate cyclohydrolase activity	1.95551536198286	bayes_pls_golite062009
DNA binding	1.70073234884672	bayes_pls_golite062009
binding	1.57522146187634	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	1.54527841865655	bayes_pls_golite062009
nucleic acid binding	1.47211855405194	bayes_pls_golite062009
malic enzyme activity	1.39067036188188	bayes_pls_golite062009
transcription factor activity	0.9895904275677	bayes_pls_golite062009
oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor	0.66392365734856	bayes_pls_golite062009
cyclohydrolase activity	0.129148522173579	bayes_pls_golite062009
ligase activity	0.0191278372003161	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: