YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|253771686, gi...
Organism:	Escherichia coli BL21(DE3)
Length:	378 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|253771686, gi....

Description	E-value	Query Range	Subject Range
gi\|74310860, gi\|... - gi\|74310860\|ref\|YP_309279.1\| putative receptor [Shigella sonnei Ss046], gi\|73854337\|gb\|AAZ87044.1\| p...	523.0	[0..1]	[378..1]
gi\|56123304 - gi\|56123304\|gb\|AAV74540.1\| H-repeat protein [Escherichia coli]	514.0	[0..1]	[378..1]
gi\|89108303, gi\|... - gi\|89108303\|ref\|AP_002083.1\| hypothetical protein [Escherichia coli str. K-12 substr. W3110], gi\|174... YDCC_ECOLI - H repeat-associated protein ydcC (ORF-H) - Escherichia coli gi\|170081131, gi... - gi\|170081131\|ref\|YP_001730451.1\| hypothetical protein ECDH10B_1591 [Escherichia coli str. K-12 subst... EG11526 - H repeat-associated putative transposase / H repeat-associated putative transposase, RhsE-linked, fu... gi\|238900684, gi... - gi\|238900684\|ref\|YP_002926480.1\| hypothetical protein BWG_1283 [Escherichia coli BW2952], gi\|2388604... EG11526 - H repeat-associated putative transposase / H repeat-associated putative transposase, RhsE-linked, fu...	513.0	[0..1]	[378..1]
gi\|15799919, gi\|... - gi\|15799919\|ref\|NP_285931.1\| hypothetical protein Z0271 [Escherichia coli O157:H7 EDL933], gi\|125129... gi\|13359697, gi\|... - gi\|15829495\|ref\|NP_308268.1\| H repeat-associated protein [Escherichia coli O157:H7], gi\|13359697\|dbj... gi\|13359697, gi\|... - gi\|15829495\|ref\|NP_308268.1\| H repeat-containing protein [Escherichia coli O157:H7 str. Sakai], gi\|1... gi\|189366392, gi... - gi\|189366392\|gb\|EDU84808.1\| ISEc3, transposase [Escherichia coli O157:H7 str. EC4501], gi\|168763454\|... gi\|217322028, gi... - gi\|217325807\|ref\|ZP_03441891.1\| ISEc3, transposase [Escherichia coli O157:H7 str. TW14588], gi\|21732... gi\|25330362, gi\|... - pir\|\|G85509 H repeat-associated protein [imported] - Escherichia coli (strain O157:H7, substrain ED...	513.0	[0..1]	[378..1]
gi\|90324801, gi\|... - gi\|90414129\|ref\|ZP_01222111.1\| Putative transposase [Photobacterium profundum 3TCK], gi\|90324801\|gb\|...	484.0	[0..1]	[378..1]

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Predicted Domain #1

Region A:
Residues: [1-378]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MELKKLMEHI SIIPDYRQTW KVEHKLSDIL LLTICAVISG AEGWEDIEDF GETHLDFLKQ  60
   61 YGDFENGIPV HDTIARVVSC ISPAKFHECF INWMRDCHSS DDKDVIAIDG KTLRHSYDKS 120
  121 RRRGAIHVIS AFSTMHSLVI GQIKTDEKSN EITAIPELLN MLDIKGKIIT TDAMGCQKDI 180
  181 AEKIQKQGGD YLFAVKGTQG RLNKAFEEKF PLKELNNPEH DSYAISEKSH GREEIRLHIV 240
  241 CDVPDELIDF TFEWKGLKKL CVAVSFRSII AEQKKEPEMT VRYYISSADL TAEKFATAIR 300
  301 NHWHVENKLH WRLDVVMNED DCKIRRGNAA ELFSGIRHIA INILTNDKVF KAGLRRKMRK 360
  361 AAMDRNYLAS VLAGSGLS

[Run NCBI BLAST on this sequence.]

Detection Method:	FFAS03
Confidence:	1.23
Match:	1muhA
Description:	Transposase inhibitor (Tn5 transposase)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.53924789709051	bayes_pls_golite062009
nuclease activity	1.33447740033502	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	1.23347009562032	bayes_pls_golite062009
hydrolase activity	1.22075366957547	bayes_pls_golite062009
exonuclease activity	1.20458535230258	bayes_pls_golite062009
transposase activity	0.965908684749648	bayes_pls_golite062009
deoxyribonuclease activity	0.330313608754008	bayes_pls_golite062009
ribonuclease activity	0.26323966197813	bayes_pls_golite062009
exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	0.248165509716873	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: