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View Structure Prediction Details

Protein: gi|48425314, gi|...
Organism: Homo sapiens
Length: 114 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|48425314, gi|....

Description E-value Query
Range
Subject
Range
BMP2_MOUSE - Bone morphogenetic protein 2 OS=Mus musculus GN=Bmp2 PE=1 SV=2
173.0 [0..1] [114..281]
gi|50253609, gi|... - gi|89271919|emb|CAJ81649.1| bone morphogenetic protein 2 [Xenopus tropicalis], gi|62857719|ref|NP_00...
173.0 [0..1] [114..285]
BMP2_RAT - Bone morphogenetic protein 2 OS=Rattus norvegicus GN=Bmp2 PE=2 SV=1
173.0 [0..1] [114..280]
BMP2B_XENLA - Bone morphogenetic protein 2-B OS=Xenopus laevis GN=bmp2-b PE=2 SV=1
172.0 [0..1] [114..285]
BMP2_DAMDA - Bone morphogenetic protein 2 OS=Dama dama GN=BMP2 PE=2 SV=1
gi|2462271 - gi|2462271|emb|CAA05033.1| Bone morphogenetic protein 2 [Dama sp.]
172.0 [0..1] [114..283]
gi|73991339 - gi|73991339|ref|XP_534351.2| PREDICTED: similar to Bone morphogenetic protein 2 precursor (BMP-2) (B...
171.0 [0..1] [114..282]

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Predicted Domain #1
Region A:
Residues: [1-114]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 QAKHKQRKRL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH  60
   61 AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 40.69897
Match: 1es7A
Description: Bone morphogenetic protein-2 (BMP-2)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
receptor binding 4.70889547404918 bayes_pls_golite062009
growth factor activity 3.55277889903829 bayes_pls_golite062009
protein binding 3.16282476674164 bayes_pls_golite062009
cytokine activity 2.99020989034786 bayes_pls_golite062009
binding 2.37954321554411 bayes_pls_golite062009
receptor serine/threonine kinase binding 2.16322447608029 bayes_pls_golite062009
transmembrane receptor protein serine/threonine kinase binding 2.00657419237426 bayes_pls_golite062009
transforming growth factor beta receptor binding 2.00657419237426 bayes_pls_golite062009
cell surface binding 1.99110766256982 bayes_pls_golite062009
vascular endothelial growth factor receptor 1 binding 1.87722086999547 bayes_pls_golite062009
type II transforming growth factor beta receptor binding 1.74489645820593 bayes_pls_golite062009
glycosaminoglycan binding 1.67879530820663 bayes_pls_golite062009
protein dimerization activity 1.44846386076063 bayes_pls_golite062009
vascular endothelial growth factor receptor 2 binding 1.44790236067538 bayes_pls_golite062009
hormone activity 1.39628583804208 bayes_pls_golite062009
heparin binding 1.30997160523692 bayes_pls_golite062009
growth factor binding 1.28535209856904 bayes_pls_golite062009
vascular endothelial growth factor receptor binding 1.1973768181124 bayes_pls_golite062009
glial cell line-derived neurotrophic factor receptor binding 1.16821412683065 bayes_pls_golite062009
polysaccharide binding 1.16191864095271 bayes_pls_golite062009
protein homodimerization activity 1.13743310822539 bayes_pls_golite062009
platelet-derived growth factor receptor binding 1.12951786832285 bayes_pls_golite062009
pattern binding 1.03800950458236 bayes_pls_golite062009
identical protein binding 1.0030262164995 bayes_pls_golite062009
neurotrophin receptor binding 0.81172494974121 bayes_pls_golite062009
protein heterodimerization activity 0.408562885230686 bayes_pls_golite062009
platelet-derived growth factor binding 0.31124485646439 bayes_pls_golite062009
fibronectin binding 0.1110090445978 bayes_pls_golite062009
collagen binding 0.0532357400924206 bayes_pls_golite062009
carbohydrate binding 0.0235054088545197 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle