YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|213610022
Organism:	Salmonella enterica subsp. enterica serovar Typhi str. E98-2068
Length:	638 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|213610022.

Description	E-value	Query Range	Subject Range
gi\|62182179, gi\|... - gi\|62182179\|ref\|YP_218596.1\| PTS family, mannitol-specific enzyme IIABC components [Salmonella enter...	0.0	[1..638]	[1..638]
gi\|194414527, gi... - gi\|75211354\|ref\|ZP_00711453.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	0.0	[1..637]	[1..637]
gi\|75228662, gi\|... - gi\|75228662\|ref\|ZP_00715283.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75188362, gi\|... - gi\|75188362\|ref\|ZP_00701629.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|75179770, gi\|... - gi\|75179770\|ref\|ZP_00699757.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|170018170, gi... - gi\|170018170\|ref\|YP_001723124.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli ATCC 87... gi\|73857644, gi\|... - gi\|74314167\|ref\|YP_312586.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella sonnei ... gi\|75255815, gi\|... - gi\|75255815\|ref\|ZP_00727561.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|124499171, gi... - gi\|124530530\|ref\|ZP_01701157.1\| PTS system, mannitol-specific IIC subunit [Escherichia coli B], gi\|1...	0.0	[1..637]	[1..637]
gi\|30065127, gi\|... - gi\|30065127\|ref\|NP_839298.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|24114863, gi\|... - gi\|24114863\|ref\|NP_709373.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexner... gi\|110617279, gi... - gi\|110807731\|ref\|YP_691251.1\| PTS system, mannitol-specific enzyme IIABC components [Shigella flexne...	0.0	[1..637]	[1..637]
gi\|117625875, gi... - gi\|117625875\|ref\|YP_859198.1\| fused mannitol-specific PTS enzymes: IIA components/IIB components/IIC... gi\|237703365, gi... - gi\|237703365\|ref\|ZP_04533846.1\| mannitol-specific PTS system enzyme IIABC component [Escherichia sp.... gi\|91074684, gi\|... - gi\|91213110\|ref\|YP_543096.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|218560670, gi... - gi\|218560670\|ref\|YP_002393583.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component...	0.0	[1..637]	[1..637]
gi\|168779748, gi... - gi\|189002293\|gb\|EDU71279.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|209747460, gi... - pir\|\|C91188 hypothetical protein ECs4475 [imported] - Escherichia coli (strain O157:H7, substrain R... gi\|189380162, gi... - gi\|189380162\|gb\|EDU98578.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|195935125 - gi\|195935125\|ref\|ZP_03080507.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia co... gi\|208725580, gi... - gi\|208805779\|ref\|ZP_03248116.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|168753416, gi... - gi\|189358801\|gb\|EDU77220.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|168759690, gi... - gi\|189369645\|gb\|EDU88061.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|189364590, gi... - gi\|189364590\|gb\|EDU83009.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|187771479, gi... - gi\|187771479\|gb\|EDU35323.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|254795553, gi... - gi\|254795553\|ref\|YP_003080390.1\| fused mannitol-specific PTS enzymes: IIA components, IIB components... gi\|188018385, gi... - gi\|188018385\|gb\|EDU56507.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157:H7 ... gi\|15833729, gi\|... - gi\|15833729\|ref\|NP_312502.1\| mannitol-specific PTS system enzyme IIABC components [Escherichia coli ... gi\|208812259, gi... - gi\|208812259\|ref\|ZP_03253588.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|208740178, gi... - gi\|208820055\|ref\|ZP_03260375.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157... gi\|209158199, gi... - gi\|209396799\|ref\|YP_002273078.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O15... gi\|217326167, gi... - gi\|217326167\|ref\|ZP_03442251.1\| PTS system, mannitol-specific IIABC component [Escherichia coli O157...	0.0	[1..637]	[1..637]
EG10615 - mannitol-specific PTS enzyme: IIA, IIB and IIC components / Mannitol-specific Enzyme IIABC of PTS tr... gi\|170083106, gi... - gi\|170083106\|ref\|YP_001732426.1\| fused mannitol-specific PTS enzymes: IIA components; IIB components... gi\|218362929, gi... - gi\|218556161\|ref\|YP_002389074.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component... gi\|209921068, gi... - gi\|209921068\|ref\|YP_002295152.1\| PTS system mannitol-specific IIABC components [Escherichia coli SE1... gi\|218354052, gi... - gi\|218697320\|ref\|YP_002404987.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component... gi\|188493211, gi... - gi\|75514334\|ref\|ZP_00736642.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|89110413, gi\|... - gi\|89110413\|ref\|AP_004193.1\| fused mannitol-specific PTS enzyme IIABC components [Escherichia coli s... gi\|238902689, gi... - gi\|238902689\|ref\|YP_002928485.1\| fused mannitol-specific PTS enzymes: IIA components/IIB components/... gi\|242379120, gi... - gi\|251786847\|ref\|YP_003001151.1\| hypothetical protein B21_03405 [Escherichia coli BL21], gi\|24237912... EG10615 - mannitol-specific PTS enzyme: IIA, IIB and IIC components / Mannitol-specific Enzyme IIABC of PTS tr... gi\|83588549, gi\|... - gi\|83588549\|ref\|ZP_00927173.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|253979583, gi... - gi\|254290276\|ref\|YP_003056024.1\| fused mannitol-specific PTS enzymes: IIA components/IIB components/... PTM3C_ECOLI, PTM... - (P00550) PTS system, mannitol-specific IIABC component (EIIABC-Mtl) (Mannitol-permease IIABC compone... gi\|157068758, gi... - gi\|75197506\|ref\|ZP_00707576.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|254038798, gi... - gi\|254038798\|ref\|ZP_04872850.1\| PTS system [Escherichia sp. 1_1_43], gi\|226838763\|gb\|EEH70790.1\| PTS... gi\|75237539, gi\|... - gi\|75237539\|ref\|ZP_00721572.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ... gi\|254163526, gi... - gi\|254163526\|ref\|YP_003046634.1\| fused mannitol-specific PTS enzymes: IIA components/IIB components/...	0.0	[1..637]	[1..637]
gi\|82545959, gi\|... - gi\|82545959\|ref\|YP_409906.1\| PTS system mannitol-specific enzyme IIABC components [Shigella boydii S...	0.0	[1..637]	[1..637]
gi\|25287847 - pir\|\|C86035 hypothetical protein mtlA [imported] - Escherichia coli (strain O157:H7, substrain EDL9... gi\|15804140, gi\|... - gi\|15804140\|ref\|NP_290179.1\| PTS system, mannitol-specific enzyme IIABC components [Escherichia coli...	0.0	[1..637]	[1..637]
gi\|227839344, gi... - gi\|227883764\|ref\|ZP_04001569.1\| protein-N(pi)-phosphohistidine--sugar phosphotransferase [Escherichi... gi\|110345432, gi... - gi\|110643840\|ref\|YP_671570.1\| PTS system, mannitol-specific IIABC component [Escherichia coli 536], ... gi\|215266950, gi... - gi\|215488878\|ref\|YP_002331309.1\| fused mannitol-specific PTS enzymes: IIA components /IIB components... gi\|218691882, gi... - gi\|218691882\|ref\|YP_002400094.1\| fused mannitol-specific PTS enzymes: IIA components ; IIB component... gi\|26250238, gi\|... - gi\|26250238\|ref\|NP_756278.1\| PTS system, mannitol-specific IIABC component [Escherichia coli CFT073]... gi\|191170342, gi... - gi\|75242618\|ref\|ZP_00726362.1\| COG2213: Phosphotransferase system, mannitol-specific IIBC component ...	0.0	[1..637]	[1..637]

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Predicted Domain #1

Region A:
Residues: [1-93]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSSDIKIKVQ SFGRFLSNMV MPNIGAFIAW GIITALFIPT GWLPNETLAK LVGPMITYLL  60
   61 PLLIGYTGGR LVGGERGGVV GAITTMGVIV GAD

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #2

Region A:
Residues: [94-336]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPMFLGSMIA GPLGGYCIKK FDSWVDGKIK SGFEMLVNNF SAGIIGMILA ILAFLGIGPA  60
   61 VEVLSKILAA GVNFMVAHDM LPLASIFVEP AKILFLNNAI NHGIFSPLGI QQSHEMGKSI 120
  121 FFLIEANPGP GMGVLLAYMF FGRGSAKQSA GGAAIIHFLG GIHEIYFPYV LMNPRLILAV 180
  181 ILGGMTGVFT LTILNGGLVS PASPGSILAV LAMTPKGAYF ANIAAIVAAM AVSFVVSAIL 240
  241 LKT

[Run NCBI BLAST on this sequence.]

Detection Method:

MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3

Region A:
Residues: [337-495]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SKVKEEDDIE AATRRMHDMK AESKGASPLA AGDVTNDLSH VRKIIVACDA GMGSSAMGAG  60
   61 VLRKKVQDAG LSQISVTNSA INNLPPDVDL VITHRDLTER AMRQVPQAQH ISLTNFLDSG 120
  121 LYTSLTERLV AAQRHNTNEE KVRDHLKDSF EEGDNNLFK

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	16.30103
Match:	1vkrA
Description:	STRUCTURE OF IIB DOMAIN OF THE MANNITOL-SPECIFIC PERMEASE ENZYME II
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	5.08041453921791	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	4.49138214292642	bayes_pls_golite062009
fructose transmembrane transporter activity	2.02791322402201	bayes_pls_golite062009
sugar transmembrane transporter activity	1.77053981674308	bayes_pls_golite062009
transporter activity	1.6837050020547	bayes_pls_golite062009
transmembrane transporter activity	1.5685227361887	bayes_pls_golite062009
monosaccharide transmembrane transporter activity	1.38987536600292	bayes_pls_golite062009
substrate-specific transporter activity	1.32293422112884	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.217268678967	bayes_pls_golite062009
active transmembrane transporter activity	1.12964417923438	bayes_pls_golite062009
hexose transmembrane transporter activity	0.80355002679172	bayes_pls_golite062009
binding	0.472595683811139	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.37663629577414	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0296784994545702	bayes_pls_golite062009

Predicted Domain #4

Region A:
Residues: [496-638]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 LGAENIFLGR KAANKEEAIR FAGEQLVKGG YVEPEYVEAM LDREKLTPTY LGESIAVPHG  60
   61 TVEAKDRVLK TGVVFCQYPE GVRFGEEEDD IARLVIGIAA RNNEHIQVIT SLTNALDDES 120
  121 VIERLAHTTS VDEVLELLAG KKA

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	37.0
Match:	1a3aA
Description:	Phosphotransferase IIa-mannitol
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
protein-N(PI)-phosphohistidine-sugar phosphotransferase activity	4.89047341597444	bayes_pls_golite062009
carbohydrate transmembrane transporter activity	3.92377913213665	bayes_pls_golite062009
transporter activity	2.16741930408232	bayes_pls_golite062009
transmembrane transporter activity	2.05879816720019	bayes_pls_golite062009
active transmembrane transporter activity	1.87457143976439	bayes_pls_golite062009
substrate-specific transporter activity	1.82451780056478	bayes_pls_golite062009
substrate-specific transmembrane transporter activity	1.7251575499811	bayes_pls_golite062009
binding	0.396676636991646	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.19707628828681	bayes_pls_golite062009
ion transmembrane transporter activity	0.12881601139602	bayes_pls_golite062009
anion transmembrane transporter activity	0.10209580008722	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions:

Predicted functions: