YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190404965
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	224 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190404965.

Description	E-value	Query Range	Subject Range
gi\|151942056 - gi\|151942056\|gb\|EDN60412.1\| oxidant-induced cell-cycle arrest [Saccharomyces cerevisiae YJM789] OCA6_YEAST - Putative tyrosine-protein phosphatase OCA6 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ... gi\|190404965 - gi\|190404965\|gb\|EDV08232.1\| conserved hypothetical protein [Saccharomyces cerevisiae RM11-1a] OCA6 - Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a mode...	1.0E-51	[1..224]	[1..224]
gi\|162319572 - gi\|162319572\|gb\|AAI56889.1\| Protein tyrosine phosphatase, receptor type, U [synthetic construct] gi\|148698181, gi... - gi\|2627027\|dbj\|BAA23475.1\| Ftp-1 [Mus musculus], gi\|148698181\|gb\|EDL30128.1\| protein tyrosine phosph...	2.0E-36	[12..216]	[981..1176]
gi\|18860902, gi\|... - gi\|57209032\|emb\|CAI41222.1\| protein tyrosine phosphatase, receptor type, K [Homo sapiens], gi\|572083... gi\|114609259 - gi\|114609259\|ref\|XP_001167740.1\| PREDICTED: protein tyrosine phosphatase, receptor type, K isoform 9...	2.0E-36	[12..220]	[989..1189]
gi\|7507776 - gi\|7507776\|pir\|\|T16867 probable cytochrome P450 T13C5.1 [similarity] - Caenorhabditis elegans	2.0E-36	[12..216]	[981..1176]

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Predicted Domain #1

Region A:
Residues: [1-224]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTLVTPLQFS TVQPNLYRGS YPREINLPFL RTLRLKYILS LTPEPLSTDP LMVKFCEENN  60
   61 IKTIHIKCQS ERKADKTKPK IKRKKKTVPI EYDVVVRCVK FLIDKGHYPC YMHCTNGELI 120
  121 ISLVVACMRK FSYWSTVSIL NEFLVYNSSI NIHERNFIEN FNSEIEVDDL DIKDKVPWIT 180
  181 VRYIARTATE SKDELRVDDA NASEKVARVS SVSNSLPKLK FHSM

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	28.0
Match:	1rpmA_
Description:	Tyrosine phosphatase
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.30669036331612	bayes_pls_golite062009
phosphatase activity	6.6585143972081	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.44546424348532	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.56007278295923	bayes_pls_golite062009
protein tyrosine phosphatase activity	5.3097342170423	bayes_pls_golite062009
hydrolase activity	4.08088661270715	bayes_pls_golite062009
transmembrane receptor protein phosphatase activity	2.94635032478625	bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity	2.94635032478625	bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity	2.77531895423367	bayes_pls_golite062009
protein serine/threonine phosphatase activity	1.95004535887255	bayes_pls_golite062009
protein binding	1.2114562222518	bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity	1.1200449509328	bayes_pls_golite062009
catalytic activity	1.06283028154109	bayes_pls_golite062009
lipid phosphatase activity	1.05085928819585	bayes_pls_golite062009
binding	0.827427419667143	bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity	0.724257798127697	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0776644624761281	bayes_pls_golite062009
kinase activity	0.0715870881653981	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: