YRC Public Data Repository - Protein Structure Prediction

Protein:	SYT_PSEA8
Organism:	Pseudomonas aeruginosa LESB58
Length:	640 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for SYT_PSEA8.

Description	E-value	Query Range	Subject Range
gi\|94310105, gi\|... - gi\|94310105\|ref\|YP_583315.1\| threonyl-tRNA synthetase [Ralstonia metallidurans CH34], gi\|93353957\|gb...	0.0	[1..635]	[29..663]
SYT_METCA - Threonyl-tRNA synthetase OS=Methylococcus capsulatus GN=thrS PE=3 SV=1 SYT_METCA - Threonine--tRNA ligase OS=Methylococcus capsulatus (strain ATCC 33009 / NCIMB 11132 / Bath) GN=thrS ...	0.0	[1..635]	[1..635]
SYT_BURS3 - Threonine--tRNA ligase OS=Burkholderia sp. (strain 383) GN=thrS PE=3 SV=1 SYT_BURL3 - Threonine--tRNA ligase OS=Burkholderia lata (strain ATCC 17760 / LMG 22485 / NCIMB 9086 / R18194 / 3...	0.0	[1..633]	[1..633]
gi\|254245609, gi... - gi\|254245609\|ref\|ZP_04938930.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia PC184]... gi\|162218055, gi... - gi\|67656296\|ref\|ZP_00453679.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia AU 1054... gi\|162227933, gi... - gi\|67668173\|ref\|ZP_00465361.1\| Threonyl-tRNA synthetase, class IIa [Burkholderia cenocepacia HI2424]...	0.0	[1..633]	[1..633]
SYT_BURVG - Threonine--tRNA ligase OS=Burkholderia vietnamiensis (strain G4 / LMG 22486) GN=thrS PE=3 SV=1	0.0	[1..633]	[1..633]
SYT_CUPPJ - Threonine--tRNA ligase OS=Cupriavidus pinatubonensis (strain JMP 134 / LMG 1197) GN=thrS PE=3 SV=1	0.0	[1..635]	[1..635]
SYT_PSESM - Threonine--tRNA ligase OS=Pseudomonas syringae pv. tomato (strain DC3000) GN=thrS PE=3 SV=1 gi\|213970495, gi... - gi\|213970495\|ref\|ZP_03398622.1\| threonyl-tRNA synthetase [Pseudomonas syringae pv. tomato T1], gi\|21... SYT_PSESM - Threonyl-tRNA synthetase OS=Pseudomonas syringae pv. tomato GN=thrS PE=3 SV=1	0.0	[1..640]	[1..640]
gi\|148027559, gi... - gi\|254358432\|ref\|ZP_04974705.1\| threonyl-tRNA synthetase [Burkholderia mallei 2002721280], gi\|194575... gi\|254206061, gi... - gi\|254206061\|ref\|ZP_04912413.1\| threonyl-tRNA synthetase [Burkholderia mallei JHU], gi\|194529494\|ref... SYT_BURPS - Threonine--tRNA ligase OS=Burkholderia pseudomallei (strain K96243) GN=thrS PE=3 SV=1 SYT_BURMA - Threonine--tRNA ligase OS=Burkholderia mallei (strain ATCC 23344) GN=thrS PE=3 SV=1 SYT_BURMA - Threonine--tRNA ligase OS=Burkholderia mallei GN=thrS PE=3 SV=1 SYT_BURPS - Threonine--tRNA ligase OS=Burkholderia pseudomallei GN=thrS PE=3 SV=1 gi\|225928297, gi... - gi\|226199711\|ref\|ZP_03795264.1\| threonine--tRNA ligase [Burkholderia pseudomallei Pakistan 9], gi\|22... gi\|237812016, gi... - gi\|237812016\|ref\|YP_002896467.1\| threonine--tRNA ligase [Burkholderia pseudomallei MSHR346], gi\|2375... gi\|238562605, gi... - gi\|238562605\|ref\|ZP_04610138.1\| threonine--tRNA ligase [Burkholderia mallei GB8 horse 4], gi\|2385222... gi\|194525325, gi... - gi\|254199739\|ref\|ZP_04906105.1\| threonyl-tRNA synthetase [Burkholderia mallei FMH], gi\|194525325\|ref... gi\|134246235, gi... - gi\|134282197\|ref\|ZP_01768902.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 305], gi\|1342462... SYT_BURM9 - Threonine--tRNA ligase OS=Burkholderia mallei (strain NCTC 10229) GN=thrS PE=3 SV=1 gi\|167902959 - gi\|167902959\|ref\|ZP_02490164.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei NCTC 13177] SYT_BURMS - Threonine--tRNA ligase OS=Burkholderia mallei (strain SAVP1) GN=thrS PE=3 SV=1 gi\|167894556 - gi\|167894556\|ref\|ZP_02481958.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 7894] SYT_BURM7 - Threonine--tRNA ligase OS=Burkholderia mallei (strain NCTC 10247) GN=thrS PE=3 SV=1 gi\|167919220 - gi\|167919220\|ref\|ZP_02506311.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei BCC215] SYT_BURP6 - Threonine--tRNA ligase OS=Burkholderia pseudomallei (strain 668) GN=thrS PE=3 SV=1 gi\|167911196 - gi\|167911196\|ref\|ZP_02498287.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 112] gi\|167816071 - gi\|167816071\|ref\|ZP_02447751.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 91] SYT_BURP0 - Threonine--tRNA ligase OS=Burkholderia pseudomallei (strain 1106a) GN=thrS PE=3 SV=1 gi\|167738851 - gi\|167738851\|ref\|ZP_02411625.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 14] gi\|167845979 - gi\|167845979\|ref\|ZP_02471487.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei B7210] gi\|167824445 - gi\|167824445\|ref\|ZP_02455916.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 9] gi\|254259413, gi... - gi\|254259413\|ref\|ZP_04950467.1\| threonine--tRNA ligase [Burkholderia pseudomallei 1710a], gi\|2542181... gi\|242141027, gi... - gi\|242317788\|ref\|ZP_04816804.1\| threonine--tRNA ligase [Burkholderia pseudomallei 1106b], gi\|2421410... gi\|167719848 - gi\|167719848\|ref\|ZP_02403084.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei DM98] gi\|167003090, gi... - gi\|243061341\|gb\|EES43527.1\| threonine--tRNA ligase [Burkholderia mallei PRL-20], gi\|167003090\|ref\|ZP... gi\|217423341, gi... - gi\|217423341\|ref\|ZP_03454842.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 576], gi\|2173931... gi\|157806992, gi... - gi\|254297839\|ref\|ZP_04965292.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 406e], gi\|194571... gi\|254180004, gi... - gi\|254180004\|ref\|ZP_04886603.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei 1655], gi\|194506... gi\|254177492, gi... - gi\|254177492\|ref\|ZP_04884147.1\| threonyl-tRNA synthetase [Burkholderia mallei ATCC 10399], gi\|194313... SYT_BURP1 - Threonine--tRNA ligase OS=Burkholderia pseudomallei (strain 1710b) GN=thrS PE=3 SV=1 gi\|254197889, gi... - gi\|254197889\|ref\|ZP_04904311.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei S13], gi\|1945150... gi\|254188582, gi... - gi\|254188582\|ref\|ZP_04895093.1\| threonyl-tRNA synthetase [Burkholderia pseudomallei Pasteur 52237], ...	0.0	[1..631]	[1..631]
gi\|167620276 - gi\|167620276\|ref\|ZP_02388907.1\| threonyl-tRNA synthetase [Burkholderia thailandensis Bt4] SYT_BURTA - Threonine--tRNA ligase OS=Burkholderia thailandensis (strain E264 / ATCC 700388 / DSM 13276 / CIP 10...	0.0	[1..631]	[1..631]
SYT_BURCM - Threonine--tRNA ligase OS=Burkholderia ambifaria (strain ATCC BAA-244 / AMMD) GN=thrS PE=3 SV=1	0.0	[1..633]	[1..633]

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Predicted Domain #1

Region A:
Residues: [1-640]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPIITLPDGS QRSFDHPVSV AEVAQSIGAG LAKATLAGKV DGRLVDACDT IDRDATLQII  60
   61 TPKDEEGLEI IRHSCAHLVG HAVKQLYPTA KMVIGPVIEE GFYYDIFFER PFTPEDMAAI 120
  121 QQRMRELIDK DYDVIKKMTP RAEVIELFKS RGEDYKLRLI DDMPDEKAMG LYFHEEYVDM 180
  181 CRGPHVPNTR FLKAFQLTKI SGAYWRGDSK NEQLQRIYGT AWADKKQLAA YIQRIEEAEK 240
  241 RDHRRIGKQL DLFHLQEEAP GMVFWHPNGW SVYQVLEQYM RKVQRDHGYV EVRTPQVVDR 300
  301 ILWERSGHWS NYAENMFTTS SESRDYAVKP MNCPCHVQIF NQGLKSYRDL PLRLAEFGAC 360
  361 HRNEPSGALH GIMRVRGFTQ DDAHIFCTEE QVKKEAADFI KLTLQVYRDF GFTDIAMKLS 420
  421 TRPAKRVGSD ELWDRAEGAL ADALNESGLA WEYQPGEGAF YGPKIEFTLK DCLGRNWQCG 480
  481 TLQYDPNLPE RLDASYIAED NNRKRPVMLH RAILGSFERF IGMLIEHYAG AFPAWLAPTQ 540
  541 AVVMNITDKQ ADFAAEVVRI LGESGFRAKS DLRNEKIGFK IREHTLLKVP YLLVIGDREV 600
  601 ESKAVAVRTR EGEDLGSMPV TQFAELLAQA VSRRGRQDSE

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	163.0
Match:	1qf6A
Description:	Threonyl-tRNA synthetase (ThrRS), C-terminal domain; Threonyl-tRNA synthetase (ThrRS), N-terminal 'additional' domain; Threonyl-tRNA synthetase (ThrRS), second 'additional' domain; Threonyl-tRNA synthetase (ThrRS)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
ligase activity, forming aminoacyl-tRNA and related compounds	7.89468709683036	bayes_pls_golite062009
ligase activity, forming carbon-oxygen bonds	7.89468709683036	bayes_pls_golite062009
aminoacyl-tRNA ligase activity	7.88410036819636	bayes_pls_golite062009
ligase activity	6.92073480193262	bayes_pls_golite062009
threonine-tRNA ligase activity	6.47381405106149	bayes_pls_golite062009
proline-tRNA ligase activity	3.75014065504119	bayes_pls_golite062009
phenylalanine-tRNA ligase activity	2.99105702052936	bayes_pls_golite062009
serine-tRNA ligase activity	2.46505535069103	bayes_pls_golite062009
glycine-tRNA ligase activity	2.29229136935761	bayes_pls_golite062009
catalytic activity	1.99372273395202	bayes_pls_golite062009
alanine-tRNA ligase activity	1.82594054955281	bayes_pls_golite062009
lysine-tRNA ligase activity	1.72324031407565	bayes_pls_golite062009
histidine-tRNA ligase activity	1.72215103383322	bayes_pls_golite062009
binding	1.11470390774037	bayes_pls_golite062009
transcription regulator activity	1.0753492604686	bayes_pls_golite062009
asparagine-tRNA ligase activity	0.921492123574877	bayes_pls_golite062009
nucleic acid binding	0.897558352141977	bayes_pls_golite062009
DNA binding	0.854148126675211	bayes_pls_golite062009
transcription repressor activity	0.55217603492525	bayes_pls_golite062009
transcription factor activity	0.283508546234551	bayes_pls_golite062009
aspartate-tRNA ligase activity	0.00572514744734753	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: