YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|190409052
Organism:	Saccharomyces cerevisiae RM11-1a
Length:	314 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|190409052.

Description	E-value	Query Range	Subject Range
MTQ1 - S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; sim... MTQ1_YEAST - Mitochondrial N(5)-glutamine methyltransferase MTQ1 OS=Saccharomyces cerevisiae (strain ATCC 204508 ... gi\|190409052 - gi\|190409052\|gb\|EDV12317.1\| hypothetical protein SCRG_03198 [Saccharomyces cerevisiae RM11-1a]	5.0E-57	[1..314]	[1..314]
gi\|14517939 - gi\|14517939\|gb\|AAK64442.1\|AF377339_3 protoporphyrinogen oxidase HemK [Myxococcus xanthus]	4.0E-49	[2..285]	[12..289]
gi\|116189310, gi... - gi\|75830360\|ref\|ZP_00759640.1\| COG2890: Methylase of polypeptide chain release factors [Vibrio chole... gi\|227082303, gi... - gi\|227082303\|ref\|YP_002810854.1\| hemK protein [Vibrio cholerae M66-2], gi\|227010191\|gb\|ACP06403.1\| h... gi\|229355249, gi... - gi\|229507744\|ref\|ZP_04397249.1\| methylase of polypeptide chain release factors [Vibrio cholerae BX 3... gi\|229369944, gi... - gi\|229607289\|ref\|YP_002877937.1\| methylase of polypeptide chain release factor [Vibrio cholerae MJ-1... HEMK_VIBCH, PRMC... - Release factor glutamine methyltransferase OS=Vibrio cholerae GN=prmC PE=3 SV=1, Protein methyltrans... PRMC_VIBCH - Release factor glutamine methyltransferase OS=Vibrio cholerae serotype O1 (strain ATCC 39315 / El To... gi\|121548967, gi... - gi\|121586800\|ref\|ZP_01676582.1\| hemK protein [Vibrio cholerae 2740-80], gi\|121548967\|gb\|EAX59006.1\| ... gi\|153223515, gi... - gi\|153223515\|ref\|ZP_01953917.1\| hemK protein [Vibrio cholerae MAK 757], gi\|124118153\|gb\|EAY36896.1\| ... gi\|153818816, gi... - gi\|153818816\|ref\|ZP_01971483.1\| hemK protein [Vibrio cholerae NCTC 8457], gi\|126510659\|gb\|EAZ73253.1... gi\|229512020, gi... - gi\|229512020\|ref\|ZP_04401499.1\| methylase of polypeptide chain release factors [Vibrio cholerae B33]...	1.0E-48	[2..285]	[9..284]
gi\|108807398, gi... - gi\|108807398\|ref\|YP_651314.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Yers... gi\|229680837, gi... - gi\|229901941\|ref\|ZP_04517062.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Yersin... gi\|145210091, gi... - gi\|145598395\|ref\|YP_001162471.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Y... gi\|149292463, gi... - gi\|149366050\|ref\|ZP_01888085.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Yersin... PRMC_YERPE - Release factor glutamine methyltransferase OS=Yersinia pestis GN=prmC PE=3 SV=1 gi\|229898072, gi... - gi\|229898072\|ref\|ZP_04513223.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Yersin... gi\|229693766, gi... - gi\|229897429\|ref\|ZP_04512585.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Yersin... gi\|45441670, gi\|... - gi\|45441670\|ref\|NP_993209.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Yersi... gi\|229702202, gi... - gi\|229894729\|ref\|ZP_04509909.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Yersin... gi\|22126174, gi\|... - gi\|22126174\|ref\|NP_669597.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Yersi... gi\|167401386, gi... - gi\|167401386\|ref\|ZP_02306883.1\| methyltransferase, HemK family [Yersinia pestis biovar Antiqua str. ... gi\|15980033, gi\|... - gi\|218929129\|ref\|YP_002347004.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Y... gi\|166961640, gi... - gi\|167419945\|ref\|ZP_02311698.1\| methyltransferase, HemK family [Yersinia pestis biovar Orientalis st... gi\|167424706, gi... - gi\|167424706\|ref\|ZP_02316459.1\| methyltransferase, HemK family [Yersinia pestis biovar Mediaevalis s... gi\|162351740, gi... - gi\|77635379\|ref\|ZP_00797464.1\| COG2890: Methylase of polypeptide chain release factors [Yersinia pes... gi\|89104289, gi\|... - gi\|89104289\|ref\|ZP_01176836.1\| COG2890: Methylase of polypeptide chain release factors [Yersinia pes... gi\|165921628, gi... - gi\|165926407\|ref\|ZP_02222239.1\| methyltransferase, HemK family [Yersinia pestis biovar Orientalis st... gi\|165991741, gi... - gi\|166009186\|ref\|ZP_02230084.1\| methyltransferase, HemK family [Yersinia pestis biovar Antiqua str. ... gi\|166211074, gi... - gi\|166211074\|ref\|ZP_02237109.1\| methyltransferase, HemK family [Yersinia pestis biovar Antiqua str. ...	2.0E-48	[2..280]	[7..273]
lcl\|NC_016856.1_... - [gene=hemK] [protein=N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase] [protein_id=Y... gi\|206708521, gi... - gi\|207856718\|ref\|YP_002243369.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|224583735, gi... - gi\|224583735\|ref\|YP_002637533.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... HEMK_SALTY - Protein methyltransferase hemK OS=Salmonella typhimurium GN=hemK PE=3 SV=2 gi\|194443667, gi... - gi\|194443667\|ref\|YP_002041025.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|194735200, gi... - gi\|194735200\|ref\|YP_002114805.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|197243898, gi... - gi\|197265643\|ref\|ZP_03165717.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [S... gi\|197939950, gi... - gi\|198245434\|ref\|YP_002215370.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica... gi\|161363093, gi... - gi\|161613729\|ref\|YP_001587694.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [S... gi\|167993218, gi... - gi\|205328672\|gb\|EDZ15436.1\| protein methyltransferase HemK [Salmonella enterica subsp. enterica sero... gi\|197289229, gi... - gi\|197289229\|gb\|EDY28596.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... gi\|205342641, gi... - gi\|205342641\|gb\|EDZ29405.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Salmo... PRMC_SALTY - Release factor glutamine methyltransferase OS=Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 7... PRMC_SALTY, HEMK... - Release factor glutamine methyltransferase OS=Salmonella typhimurium GN=prmC PE=3 SV=2, Protein meth... gi\|62127972, gi\|... - gi\|62180339\|ref\|YP_216756.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo...	9.0E-48	[2..280]	[7..274]
gi\|15830971, gi\|... - gi\|15830971\|ref\|NP_309744.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Esche... gi\|209772526, gi... - pir\|\|B85701 probable protoporphyrinogen oxidase hemK [imported] - Escherichia coli (strain O157:H7, ... gi\|208732172, gi... - gi\|208815524\|ref\|ZP_03256703.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [E... gi\|208726334, gi... - gi\|208806533\|ref\|ZP_03248870.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [E... gi\|15801441, gi\|... - gi\|15801441\|ref\|NP_287458.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Esche... gi\|195939100 - gi\|195939100\|ref\|ZP_03084482.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Es... gi\|15830971, gi\|... - gi\|15830971\|ref\|NP_309744.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Esche... gi\|168801525, gi... - gi\|189376321\|gb\|EDU94737.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|217328046, gi... - gi\|217328046\|ref\|ZP_03444128.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [E... gi\|209396125, gi... - gi\|209396125\|ref\|YP_002270146.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [... gi\|208738172, gi... - gi\|208822687\|ref\|ZP_03263006.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [E... gi\|189365629, gi... - gi\|189365629\|gb\|EDU84045.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|168758137, gi... - gi\|189354975\|gb\|EDU73394.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|168750772, gi... - gi\|188015064\|gb\|EDU53186.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|189372472, gi... - gi\|189372472\|gb\|EDU90888.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|189000050, gi... - gi\|189000050\|gb\|EDU69036.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|168776895, gi... - gi\|187767812\|gb\|EDU31656.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|189360088, gi... - gi\|189360088\|gb\|EDU78507.1\| protein-(glutamine-N5) methyltransferase, release factor-specific [Esche... gi\|254592082, gi... - gi\|254792682\|ref\|YP_003077519.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Esche...	1.0E-47	[2..280]	[7..274]
gi\|169888675, gi... - gi\|170080840\|ref\|YP_001730160.1\| release factors RF-1 and RF-2 N5-glutamine methyltransferase [Esche... gi\|169755349, gi... - gi\|170020421\|ref\|YP_001725375.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [E... gi\|124500637, gi... - gi\|124528405\|ref\|ZP_01699715.1\| modification methylase, HemK family [Escherichia coli B], gi\|1245006... gi\|238900443, gi... - gi\|238900443\|ref\|YP_002926239.1\| N5-glutamine methyltransferase, modifies release factors RF-1 and R... gi\|218553766, gi... - gi\|218553766\|ref\|YP_002386679.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [E... EG12424 - RF-1 and RF-2 N5-glutamine methyltransferase / Release factor (RF1, RF2) glutamine methyltransferase PRMC_SHIFL - Release factor glutamine methyltransferase OS=Shigella flexneri GN=prmC PE=3 SV=1 gi\|24051516, gi\|... - gi\|24112611\|ref\|NP_707121.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Shige... gi\|30062736, gi\|... - gi\|30062736\|ref\|NP_836907.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Shige... EG12424 - RF-1 and RF-2 N5-glutamine methyltransferase / Release factor (RF1, RF2) glutamine methyltransferase HEMK_ECOLI - Protein methyltransferase hemK (EC 2.1.1.-) (Protein-glutamine N-methyltransferase hemK) (Protein-(g... gi\|187428004, gi... - gi\|75179189\|ref\|ZP_00699207.1\| COG2890: Methylase of polypeptide chain release factors [Shigella boy... gi\|1651602, gi\|8... - gi\|89108057\|ref\|AP_001837.1\| N5-glutamine methyltransferase, modifies release factors RF-1 and RF-2 ... gi\|188487404, gi... - gi\|75511752\|ref\|ZP_00734381.1\| COG2890: Methylase of polypeptide chain release factors [Escherichia ... gi\|75195365, gi\|... - gi\|75195365\|ref\|ZP_00705435.1\| COG2890: Methylase of polypeptide chain release factors [Escherichia ...	3.0E-47	[2..280]	[7..274]
gi\|29137200, gi\|... - gi\|29141573\|ref\|NP_804915.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo... gi\|16760668 - gi\|16760668\|ref\|NP_456285.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Salmo... gi\|214001939 - gi\|214001939\|ref\|ZP_03412674.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa... gi\|25513362, gi\|... - gi\|25513362\|pir\|\|AI0719 HemK protein, probable protoporphyrinogen oxidase hemK [imported] - Salmonel... gi\|213859592 - gi\|213859592\|ref\|ZP_03385296.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa... gi\|213581390 - gi\|213581390\|ref\|ZP_03363216.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa... gi\|213426496 - gi\|213426496\|ref\|ZP_03359246.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa... gi\|213419807 - gi\|213419807\|ref\|ZP_03352873.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa... gi\|213051785 - gi\|213051785\|ref\|ZP_03344663.1\| N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase [Sa...	5.0E-47	[2..280]	[7..274]
PRMC_XYLFA - Release factor glutamine methyltransferase OS=Xylella fastidiosa (strain 9a5c) GN=prmC PE=3 SV=1 PRMC_XYLFA, HEMK... - Release factor glutamine methyltransferase OS=Xylella fastidiosa GN=prmC PE=3 SV=1, Protein methyltr...	2.0E-44	[7..280]	[6..271]
PRMC_FUSNN - Release factor glutamine methyltransferase OS=Fusobacterium nucleatum subsp. nucleatum (strain ATCC ...	4.0E-44	[7..282]	[65..335]

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Predicted Domain #1

Region A:
Residues: [1-69]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MPRISTSLIR KASRIRPGLH LLLPECRTLE QAKLEYKWLT EELPPDKSIR WACLQRYKHV  60
   61 PLQYILRSQ

[Run NCBI BLAST on this sequence.]

Detection Method:

deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted functions:

Term	Confidence	Notes
catalytic activity	1.25333584501255	bayes_pls_golite062009
transferase activity	1.07321114919891	bayes_pls_golite062009
transcription regulator activity	1.01607844066443	bayes_pls_golite062009
DNA binding	0.94293886328487	bayes_pls_golite062009
S-adenosylmethionine-dependent methyltransferase activity	0.837368219068434	bayes_pls_golite062009
nucleic acid binding	0.731396842794323	bayes_pls_golite062009
transferase activity, transferring one-carbon groups	0.644010137949015	bayes_pls_golite062009
methyltransferase activity	0.635463629299812	bayes_pls_golite062009
binding	0.546744797014504	bayes_pls_golite062009
N-methyltransferase activity	0.290696180200503	bayes_pls_golite062009
protein methyltransferase activity	0.197622476100051	bayes_pls_golite062009

Predicted Domain #2

Region A:
Residues: [70-314]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PFGALDIVCK PGVLIPRWET EEWVMAIIRA LNNSMLSRHT IPLHICDTFT GTGCIALALS  60
   61 HGIANCTFTA IDVSTRAIKL VKENMLKNKV SGGKLVQHNI LSSKASDEYP SHIDILTGNP 120
  121 PYIRKRDFNR DVKTSVKLFE PRLALVGELE CYINLVNYWL PKTDSFFYEI GDVEQFNYVE 180
  181 RRIKEDSYLS RIWSIGLKYD SNGKARVVYG FKATPKGRIL HQIFASFGTI RHLATALSGH 240
  241 KANCN

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	18.0
Match:	1dusA_
Description:	Hypothetical protein MJ0882
Matching Structure (courtesy of the PDB):

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: