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View Structure Prediction Details

Protein: gi|168275840
Organism: synthetic construct
Length: 824 amino acids
Reference: Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|168275840.

Description E-value Query
Range
Subject
Range
gi|73670079, gi|... - gi|73670079|ref|YP_306094.1| TPR repeat-containing protein [Methanosarcina barkeri str. Fusaro], gi|...
3.0E-89 [17..823] [89..885]
gi|33640682, gi|... - gi|33862569|ref|NP_894129.1| TPR repeat-containing protein [Prochlorococcus marinus str. MIT 9313], ...
6.0E-89 [19..823] [171..964]
gi|113477431, gi... - gi|71673743|ref|ZP_00671491.1| TPR repeat:TPR-related region [Trichodesmium erythraeum IMS101], gi|7...
8.0E-89 [20..823] [751..1536]
gi|16554577 - gi|16554577|ref|NP_001247.2| cell division cycle protein 27 [Homo sapiens]
3.0E-78 [1..824] [1..824]
gi|114666430 - gi|114666430|ref|XP_511624.2| PREDICTED: cell division cycle protein 27 isoform 5 [Pan troglodytes]
4.0E-78 [1..824] [1..824]
gi|109116522 - gi|109116522|ref|XP_001115994.1| PREDICTED: cell division cycle protein 27 isoform 2 [Macaca mulatta...
1.0E-77 [1..824] [1..824]
gi|91079875 - gi|91079875|ref|XP_967579.1| PREDICTED: similar to CG10392-PB, isoform B [Tribolium castaneum]
3.0E-77 [355..824] [150..619]
gi|115699987, gi... - gi|115930468|ref|XP_001192487.1| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus], gi...
4.0E-77 [13..823] [1352..2157]

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Predicted Domain #1
Region A:
Residues: [1-288]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MTVLQEPVQA AIWQALNHYA YRDAVFLAER LYAEVHSEEA LFLLATCYYR SGKAYKAYRL  60
   61 LKGHSCTTPQ CKYLLAKCCV DLSKLAEGEQ ILSGGVFNKQ KSHDDIVTEF GDSACFTLSL 120
  121 LGHVYCKTDR LAKGSECYQK SLSLNPFLWS PFESLCEIGE KPDPDQTFKF TSLQNFSNCL 180
  181 PNSCTTQVPN HSLSHRQPET VLTETPQDTI ELNRLNLESS NSKYSLNTDS SVSYIDSAVI 240
  241 SPDTVPLGTG TSILSKQVQN KPKTGRSLLG GPAALSPLTP SFGILPLE

[Run NCBI BLAST on this sequence.]

Detection Method: FFAS03
Confidence: 2.54
Match: 2gw1A
Description: No description for 2gw1A was found.

Predicted Domain #2
Region A:
Residues: [289-369]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 TPSPGDGSYL QNYTNTPPVI DVPSTGAPSK KSVARIGQTG TKSVFSQSGN SREVTPILAQ  60
   61 TQSSGPQTST TPQVLSPTIT S

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below are all of our de novo (Rosetta) predictions for this domain.
Click here to view only most confident match.

Found no structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [370-824]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPNALPRRSS RLFTSDSSTT KENSKKLKMK FPPKIPNRKT KSKTNKGGIT QPNINDSLEI  60
   61 TKLDSSIISE GKISTITPQI QAFNLQKAAA EGLMSLLREM GKGYLALCSY NCKEAINILS 120
  121 HLPSHHYNTG WVLCQIGRAY FELSEYMQAE RIFSEVRRIE NYRVEGMEIY STTLWHLQKD 180
  181 VALSVLSKDL TDMDKNSPEA WCAAGNCFSL QREHDIAIKF FQRAIQVDPN YAYAYTLLGH 240
  241 EFVLTEELDK ALACFRNAIR VNPRHYNAWY GLGMIYYKQE KFSLAEMHFQ KALDINPQSS 300
  301 VLLCHIGVVQ HALKKSEKAL DTLNKAIVID PKNPLCKFHR ASVLFANEKY KSALQELEEL 360
  361 KQIVPKESLV YFLIGKVYKK LGQTHLALMN FSWAMDLDPK GANNQIKEAI DKRYLPDDEE 420
  421 PITQEEQIMG TDESQESSMT DADDTQLHAA ESDEF

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 56.045757
Match: 1w3bA
Description: The superhelical TPR domain of O-linked GlcNAc transferase reveals structural similarities to importin alpha.
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
binding 2.52126334054344 bayes_pls_golite062009
protein binding 1.52807685989528 bayes_pls_golite062009
hydrolase activity 0.73439282112774 bayes_pls_golite062009
enzyme binding 0.44905827271946 bayes_pls_golite062009
nucleic acid binding 0.41706917101675 bayes_pls_golite062009
transcription regulator activity 0.322371143360832 bayes_pls_golite062009
small conjugating protein ligase activity 0.244038930707726 bayes_pls_golite062009
ubiquitin-protein ligase activity 0.215617899962405 bayes_pls_golite062009
DNA binding 0.17736976899009 bayes_pls_golite062009

YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle