YRC Public Data Repository - Protein Structure Prediction

Protein:	HSLU_YERPY
Organism:	Yersinia pseudotuberculosis YPIII
Length:	443 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for HSLU_YERPY.

Description	E-value	Query Range	Subject Range
HSLU_PHOLL - ATP-dependent hsl protease ATP-binding subunit hslU OS=Photorhabdus luminescens subsp. laumondii GN=... HSLU_PHOLL - ATP-dependent protease ATPase subunit HslU OS=Photorhabdus luminescens subsp. laumondii (strain DSM ...	6.0E-63	[1..443]	[1..443]
gi\|238726266, gi... - gi\|77977397\|ref\|ZP_00832847.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Yersin...	2.0E-62	[1..443]	[1..443]
HSLU_ERWCT - ATP-dependent protease ATPase subunit HslU OS=Erwinia carotovora subsp. atroseptica GN=hslU PE=3 SV=... HSLU_PECAS - ATP-dependent protease ATPase subunit HslU OS=Pectobacterium atrosepticum (strain SCRI 1043 / ATCC B...	2.0E-62	[1..443]	[1..443]
gi\|238789597, gi... - gi\|77972978\|ref\|ZP_00828532.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Yersin...	3.0E-62	[1..443]	[1..443]
gi\|89093515, gi\|... - gi\|89093515\|ref\|ZP_01166463.1\| ATP-dependent protease ATP-binding subunit [Oceanospirillum sp. MED92...	5.0E-62	[1..443]	[1..444]
gi\|227885327, gi... - gi\|227885327\|ref\|ZP_04003132.1\| ATP-dependent protease ATP-binding subunit [Escherichia coli 83972],... gi\|226902901, gi... - gi\|237702964\|ref\|ZP_04533445.1\| ATP-dependent protease ATP-binding subunit [Escherichia sp. 3_2_53FA... HSLU_ECOK1 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O1:K1 / APEC GN=hslU PE=3 SV=1 HSLU_ECOL6 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O6 GN=hslU PE=2 SV=1 HSLU_ECOL6 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / ... HSLU_ECOL5 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O6:K15:H31 (strain 536 / UPEC) GN=hsl... HSLU_ECO27 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=h... sp\|B7UNQ1\|HSLU_ECO27 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O127:H6 (strain E2348/69 / EPEC) GN=h... HSLU_ECOUT - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli (strain UTI89 / UPEC) GN=hslU PE=3 SV... HSLU_ECOSM - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli (strain SMS-3-5 / SECEC) GN=hslU PE=3... gi\|190907027, gi... - gi\|75240324\|ref\|ZP_00724264.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Escher... HSLU_ECO81 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O81 (strain ED1a) GN=hslU PE=3 SV=1 HSLU_ECO45 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O45:K1 (strain S88 / ExPEC) GN=hslU P... HSLU_ECOLU - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O17:K52:H18 (strain UMN026 / ExPEC) G... HSLU_ECO7I - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O7:K1 (strain IAI39 / ExPEC) GN=hslU ...	5.0E-62	[1..443]	[1..443]
HSLU_HAES1 - ATP-dependent protease ATPase subunit HslU OS=Haemophilus somnus (strain 129Pt) GN=hslU PE=3 SV=1	5.0E-62	[1..443]	[1..443]
HSLU_HISS2 - ATP-dependent protease ATPase subunit HslU OS=Histophilus somni (strain 2336) GN=hslU PE=3 SV=1	5.0E-62	[1..443]	[1..443]
gi\|238786105, gi... - gi\|77957389\|ref\|ZP_00821446.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Yersin... gi\|238717841, gi... - gi\|77961039\|ref\|ZP_00824887.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Yersin...	7.0E-62	[1..443]	[1..443]
gi\|83569803, gi\|... - gi\|83569803\|ref\|ZP_00921252.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Shigel... gi\|83586225, gi\|... - gi\|83586225\|ref\|ZP_00924861.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Escher... gi\|75513883, gi\|... - gi\|75513883\|ref\|ZP_00736236.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Escher... HSLU_SHISS - ATP-dependent protease ATPase subunit HslU OS=Shigella sonnei (strain Ss046) GN=hslU PE=3 SV=1 HSLU_ECOHS - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O9:H4 (strain HS) GN=hslU PE=3 SV=1 gi\|75238374, gi\|... - gi\|75238374\|ref\|ZP_00722373.1\| COG1220: ATP-dependent protease HslVU (ClpYQ), ATPase subunit [Escher... gi\|217325487, gi... - gi\|217325487\|ref\|ZP_03441571.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157... gi\|124527592, gi... - gi\|124527592\|ref\|ZP_01699057.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli B], ... gi\|208739564, gi... - gi\|208819441\|ref\|ZP_03259761.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157... gi\|15834112, gi\|... - gi\|15834112\|ref\|NP_312885.1\| ATP-dependent protease ATP-binding subunit HslU [Escherichia coli O157:... HSLU_SHIF8 - ATP-dependent protease ATPase subunit HslU OS=Shigella flexneri serotype 5b (strain 8401) GN=hslU PE... EG11881 - molecular chaperone and ATPase component of HslUV protease / Heat-inducible ATP-dependent protease H... HSLU_ECOBW - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli (strain K12 / MC4100 / BW2952) GN=hsl... gi\|242379467, gi... - gi\|251787194\|ref\|YP_003001498.1\| hypothetical protein B21_03765 [Escherichia coli BL21], gi\|24237946... gi\|253979939, gi... - gi\|254290632\|ref\|YP_003056380.1\| ATP-dependent protease ATP-binding subunit [Escherichia coli BL21(D... gi\|254039192, gi... - gi\|254039192\|ref\|ZP_04873242.1\| heat shock protein hslU [Escherichia sp. 1_1_43], gi\|226838628\|gb\|EE... gi\|254163881, gi... - gi\|254163881\|ref\|YP_003046989.1\| ATP-dependent protease ATP-binding subunit [Escherichia coli B str.... gi\|254795933, gi... - gi\|254795933\|ref\|YP_003080770.1\| molecular chaperone and ATPase component of HslUV protease [Escheri... HSLU_SHIFL - ATP-dependent protease ATPase subunit HslU OS=Shigella flexneri GN=hslU PE=3 SV=1 gi\|24054510, gi\|... - gi\|24115225\|ref\|NP_709735.1\| ATP-dependent protease ATP-binding subunit [Shigella flexneri 2a str. 3... gi\|30064776, gi\|... - gi\|30064776\|ref\|NP_838947.1\| ATP-dependent protease ATP-binding subunit [Shigella flexneri 2a str. 2... HSLU_ECO57 - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli O157:H7 GN=hslU PE=3 SV=1 EG11881 - molecular chaperone and ATPase component of HslUV protease / Heat-inducible ATP-dependent protease H... gi\|12518837, gi\|... - gi\|15804522\|ref\|NP_290562.1\| ATP-dependent protease ATP-binding subunit [Escherichia coli O157:H7 ED... gi\|189001486, gi... - gi\|189001486\|gb\|EDU70472.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|187769191, gi... - gi\|187769191\|gb\|EDU33035.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|168799486, gi... - gi\|189378023\|gb\|EDU96439.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|168786789, gi... - gi\|189373351\|gb\|EDU91767.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|195937575 - gi\|195937575\|ref\|ZP_03082957.1\| ATP-dependent protease ATP-binding subunit [Escherichia coli O157:H7... HSLU_ECODH - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli (strain K12 / DH10B) GN=hslU PE=3 SV=... gi\|208734424, gi... - gi\|208813147\|ref\|ZP_03254476.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157... HSLU_ECOLI - ATP-dependent hsl protease ATP-binding subunit hslU (Heat shock protein hslU) - Escherichia coli HSLU_ECOLC - ATP-dependent protease ATPase subunit HslU OS=Escherichia coli (strain ATCC 8739 / DSM 1576 / Crooks... gi\|208728816, gi... - gi\|208809015\|ref\|ZP_03251352.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157... HSLU_SHIBS - ATP-dependent protease ATPase subunit HslU OS=Shigella boydii serotype 4 (strain Sb227) GN=hslU PE=3... gi\|85676129, gi\|... - gi\|89110098\|ref\|AP_003878.1\| molecular chaperone and ATPase component of HslUV protease [Escherichia... gi\|168755617, gi... - gi\|189357218\|gb\|EDU75637.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|188016819, gi... - gi\|188016819\|gb\|EDU54941.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|168768235, gi... - gi\|189362747\|gb\|EDU81166.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ... gi\|168761683, gi... - gi\|189367913\|gb\|EDU86329.1\| heat shock protein HslVU, ATPase subunit HslU [Escherichia coli O157:H7 ...	9.0E-62	[1..443]	[1..443]

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Predicted Domain #1

Region A:
Residues: [1-443]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSEMTPREIV SELDSHIIGQ DKAKRAVAIA LRNRWRRMQL NEELRHEVTP KNILMIGPTG  60
   61 VGKTEIARRL AKLANAPFIK VEATKFTEVG YVGKEVDSII RDLTDAAVKM VRHQSIEKMR 120
  121 YRAEELAEER ILDVLIPPAK NNWGVPDESQ EPSATRQTFR KKLREGQLDD KEIEIDLAAA 180
  181 PMGVEIMAPP GMEEMTNQLQ SMFQNIAGQK QKPRKIKIKE ALKLLIEEEA AKLVNPEELK 240
  241 QQAIDAVEQH GIVFIDEIDK ICKRGQTSGP DVSREGVQRD LLPLVEGCTV STKHGMVKTD 300
  301 HILFIASGAF QVSSPSDLIP ELQGRLPIRV ELQALTTDDF ERILTEPSAS LTEQYKALMA 360
  361 TEGVTIEFTR EGIRKIAEAA WQVNERTENI GARRLHTVLE RLMEDISYDA SESSGQSITI 420
  421 DAEYVGKHLD ELVADEDLSR FIL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	63.30103
Match:	1g4aE
Description:	HslU
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
hydrolase activity	2.55157966585974	bayes_pls_golite062009
binding	1.31163400557981	bayes_pls_golite062009
catalytic activity	1.00104173493322	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides	0.546796591575762	bayes_pls_golite062009
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	0.543610140926125	bayes_pls_golite062009
pyrophosphatase activity	0.540750418412449	bayes_pls_golite062009
nucleoside-triphosphatase activity	0.517457589081898	bayes_pls_golite062009
purine nucleotide binding	0.428373955572763	bayes_pls_golite062009
purine ribonucleotide binding	0.424644011903671	bayes_pls_golite062009
ribonucleotide binding	0.424583288440993	bayes_pls_golite062009
nucleotide binding	0.422354428195324	bayes_pls_golite062009
ATP binding	0.04834397972685	bayes_pls_golite062009
adenyl ribonucleotide binding	0.0149501427627318	bayes_pls_golite062009
adenyl nucleotide binding	0.00365326483311895	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: