YRC Public Data Repository - Protein Structure Prediction

Protein:	TRPC_PROMA
Organism:	Prochlorococcus marinus
Length:	293 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for TRPC_PROMA.

Description	E-value	Query Range	Subject Range
gi\|7428356 - pir\|\|S76016 hypothetical protein - Synechocystis sp. (strain PCC 6803) TRPC_SYNY3 - Indole-3-glycerol phosphate synthase OS=Synechocystis sp. (strain ATCC 27184 / PCC 6803 / N-1) GN=tr... TRPC_SYNY3 - Indole-3-glycerol phosphate synthase OS=Synechocystis sp. (strain PCC 6803 / Kazusa) GN=trpC PE=3 SV...	304.0	[0..1]	[293..1]
TRPC_TRIEI - Indole-3-glycerol phosphate synthase OS=Trichodesmium erythraeum (strain IMS101) GN=trpC PE=3 SV=1	304.0	[0..1]	[292..1]
gi\|53765692, gi\|... - gi\|75908147\|ref\|YP_322443.1\| indole-3-glycerol-phosphate synthase [Anabaena variabilis ATCC 29413], ...	304.0	[0..1]	[292..1]
gi\|17232238, gi\|... - gi\|17232238\|ref\|NP_488786.1\| indole-3-glycerol-phosphate synthase [Nostoc sp. PCC 7120], gi\|17133883... gi\|25291424 - pir\|\|AB2399 indole-3-glycerol phosphate synthase [imported] - Nostoc sp. (strain PCC 7120)	302.0	[0..1]	[291..1]
gi\|67920093, gi\|... - gi\|67920093\|ref\|ZP_00513613.1\| Indole-3-glycerol-phosphate synthase [Crocosphaera watsonii WH 8501],...	300.0	[0..1]	[292..1]
TRPC_SYNPX - Indole-3-glycerol phosphate synthase OS=Synechococcus sp. (strain WH8102) GN=trpC PE=3 SV=1	299.0	[0..1]	[292..1]
gi\|23130018, gi\|... - gi\|23130018\|ref\|ZP_00111839.1\| COG0134: Indole-3-glycerol phosphate synthase [Nostoc punctiforme PCC...	299.0	[0..1]	[292..1]
TRPC_PROMP - Indole-3-glycerol phosphate synthase OS=Prochlorococcus marinus subsp. pastoris (strain CCMP1986 / M...	297.0	[0..1]	[292..1]
TRPC_PROM4 - Indole-3-glycerol phosphate synthase OS=Prochlorococcus marinus (strain MIT 9211) GN=trpC PE=3 SV=1	297.0	[0..1]	[293..1]
TRPC_PROM9 - Indole-3-glycerol phosphate synthase OS=Prochlorococcus marinus (strain MIT 9312) GN=trpC PE=3 SV=1	296.0	[0..1]	[292..1]

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Predicted Domain #1

Region A:
Residues: [1-293]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MEIRRRPPNP KVKVANLEYA IPHEESEPRN ILEKIVWEKD REVELARHRL PLPKLIAKIE  60
   61 KLSDTKNFLQ TLKDSVTSPA VIAEIKKASP SRGLIREDFK PGDIAIAYQK GGATCLSVLT 120
  121 DKTFFQGGFD VLADVRKIID IPLLCKDFIL HPYQIYQARA SGADAILLIA AILSDQDLMY 180
  181 LNKIALSLGL SILVEVHDAA ELNRVLRLGG FPLIGINNRD LKTFETDLTT TCKVATECSN 240
  241 LLKEQDVLLV SESGIFTRED LQKVASFGAS AVLIGESLMR QKDLTNALKE LIG

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	60.39794
Match:	1piiA
Description:	THREE-DIMENSIONAL STRUCTURE OF THE BIFUNCTIONAL ENZYME PHOSPHORIBOSYLANTHRANILATE ISOMERASE: INDOLEGLYCEROLPHOSPHATE SYNTHASE FROM ESCHERICHIA COLI REFINED AT 2.0 ANGSTROMS RESOLUTION
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
tryptophan synthase activity	3.15663465352598	bayes_pls_golite062009
indole-3-glycerol-phosphate synthase activity	3.12120866545322	bayes_pls_golite062009
catalytic activity	2.81275055404078	bayes_pls_golite062009
phosphoribosylanthranilate isomerase activity	2.655130814615	bayes_pls_golite062009
carbon-carbon lyase activity	2.44001937916931	bayes_pls_golite062009
carboxy-lyase activity	1.80978905789979	bayes_pls_golite062009
lyase activity	0.9228652996943	bayes_pls_golite062009
imidazoleglycerol-phosphate synthase activity	0.82314869965119	bayes_pls_golite062009
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity	0.302746738903759	bayes_pls_golite062009
isomerase activity	0.14149405165663	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: