YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|99031990, gi\|...
Organism:	Homo sapiens
Length:	198 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|99031990, gi|....

Description	E-value	Query Range	Subject Range
gi\|67548282, gi\|... - gi\|67548282\|ref\|ZP_00426173.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	166.0	[0..2]	[191..321]
HPGDS_CHICK - Hematopoietic prostaglandin D synthase OS=Gallus gallus GN=HPGDS PE=1 SV=3	165.0	[0..1]	[198..2]
gi\|92393760, gi\|... - gi\|93006082\|ref\|YP_580519.1\| glutathione S-transferase-like [Psychrobacter cryohalolentis K5], gi\|92...	165.0	[0..6]	[189..4]
gi\|67104621, gi\|... - gi\|67662036\|ref\|ZP_00459327.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	165.0	[0..2]	[191..20]
gi\|71037973, gi\|... - gi\|71064988\|ref\|YP_263715.1\| glutathione S-transferase [Psychrobacter arcticus 273-4], gi\|71037973\|g...	165.0	[0..6]	[198..4]
gi\|114563329, gi... - gi\|69953777\|ref\|ZP_00640761.1\| Glutathione S-transferase, N-terminal:Glutathione S-transferase, C-te...	164.0	[0..3]	[198..1]
gi\|116331951, gi... - gi\|116331951\|ref\|YP_801669.1\| glutathione transferase [Leptospira borgpetersenii serovar Hardjo-bovi...	164.0	[0..7]	[188..5]
gi\|116327436, gi... - gi\|116327436\|ref\|YP_797156.1\| glutathione transferase [Leptospira borgpetersenii serovar Hardjo-bovi...	163.0	[0..7]	[188..5]
gi\|109084410 - gi\|109084410\|ref\|XP_001101990.1\| PREDICTED: similar to glutathione transferase zeta 1 isoform 1 isof...	163.0	[0..2]	[197..5]
gi\|48770838, gi\|... - gi\|94309912\|ref\|YP_583122.1\| glutathione S-transferase-like protein [Ralstonia metallidurans CH34], ...	163.0	[0..7]	[191..5]

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Predicted Domain #1

Region A:
Residues: [1-198]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PNYKLTYFNM RGRAEIIRYI FAYLDIQYED HRIEQADWPE IKSTLPFGKI PILEVDGLTL  60
   61 HQSLAIARYL TKNTDLAGNT EMEQCHVDAI VDTLDDFMSC FPWAEKKQDV KEQMFNELLT 120
  121 YNAPHLMQDL DTYLGGREWL IGMSVTWADF YWEICSTTLL VFKPDLLDNH PRLVTLRKKV 180
  181 QAIPAVANWI KRRPQTKL

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	38.0
Match:	1iyhA
Description:	Class sigma GST
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
glutathione transferase activity	6.60826314743946	bayes_pls_golite062009
glutathione binding	4.7376226932867	bayes_pls_golite062009
prostaglandin-D synthase activity	3.77818075962089	bayes_pls_golite062009
selenium binding	2.55069860113032	bayes_pls_golite062009
peroxiredoxin activity	2.12777217096121	bayes_pls_golite062009
thioredoxin peroxidase activity	1.96134566495756	bayes_pls_golite062009
binding	1.88459444245046	bayes_pls_golite062009
peroxidase activity	1.59076672517706	bayes_pls_golite062009
oxidoreductase activity, acting on peroxide as acceptor	1.59076672517706	bayes_pls_golite062009
glutathione peroxidase activity	1.5387107123358	bayes_pls_golite062009
antioxidant activity	1.51565097989188	bayes_pls_golite062009
molecular transducer activity	1.03696928411308	bayes_pls_golite062009
signal transducer activity	1.03696928411308	bayes_pls_golite062009
catalytic activity	0.963623964325467	bayes_pls_golite062009
phospholipid-hydroperoxide glutathione peroxidase activity	0.874146425427531	bayes_pls_golite062009
protein binding	0.608998866513518	bayes_pls_golite062009
transcription regulator activity	0.547631451548912	bayes_pls_golite062009
transferase activity, transferring alkyl or aryl (other than methyl) groups	0.44372379417457	bayes_pls_golite062009
receptor binding	0.430107649265259	bayes_pls_golite062009
maleylacetoacetate isomerase activity	0.426921894831614	bayes_pls_golite062009
DNA binding	0.278017923256183	bayes_pls_golite062009
nucleic acid binding	0.27489371858599	bayes_pls_golite062009
protein disulfide oxidoreductase activity	0.0719543694089202	bayes_pls_golite062009
transcription repressor activity	0.00678211696545472	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: