YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|46015795, gi\|...
Organism:	Mycobacterium tuberculosis
Length:	316 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|46015795, gi|....

Description	E-value	Query Range	Subject Range
TRUB_PSEAB - tRNA pseudouridine synthase B OS=Pseudomonas aeruginosa (strain UCBPP-PA14) GN=truB PE=3 SV=1	343.0	[0..5]	[291..11]
TRUB_PSEAE - tRNA pseudouridine synthase B OS=Pseudomonas aeruginosa GN=truB PE=3 SV=2 gi\|107103841 - gi\|107103841\|ref\|ZP_01367759.1\| hypothetical protein PaerPA_01004912 [Pseudomonas aeruginosa PACS2] TRUB_PSEAE - tRNA pseudouridine synthase B OS=Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / L... gi\|254238521, gi... - gi\|84317377\|ref\|ZP_00965825.1\| COG0130: Pseudouridine synthase [Pseudomonas aeruginosa C3719], gi\|25... gi\|218893837, gi... - gi\|218893837\|ref\|YP_002442706.1\| tRNA pseudouridine 55 synthase [Pseudomonas aeruginosa LESB58], gi\|... gi\|194555341, gi... - gi\|84323601\|ref\|ZP_00971670.1\| COG0130: Pseudouridine synthase [Pseudomonas aeruginosa 2192], gi\|254...	342.0	[0..5]	[291..11]
TRUB_PSEA7 - tRNA pseudouridine synthase B OS=Pseudomonas aeruginosa (strain PA7) GN=truB PE=3 SV=1	340.0	[0..5]	[291..11]
TRUB_PSEP1 - tRNA pseudouridine synthase B OS=Pseudomonas putida (strain F1 / ATCC 700007) GN=truB PE=3 SV=1	340.0	[0..4]	[291..10]
TRUB_PSEPF - tRNA pseudouridine synthase B OS=Pseudomonas fluorescens (strain Pf0-1) GN=truB PE=3 SV=1	339.0	[0..4]	[291..10]
gi\|32033694 - gi\|32033694\|ref\|ZP_00133989.1\| COG0130: Pseudouridine synthase [Actinobacillus pleuropneumoniae sero... TRUB_ACTP2 - tRNA pseudouridine synthase B OS=Actinobacillus pleuropneumoniae serotype 5b (strain L20) GN=truB PE...	338.0	[0..7]	[291..13]
TRUB_PSEF5 - tRNA pseudouridine synthase B OS=Pseudomonas fluorescens (strain Pf-5 / ATCC BAA-477) GN=truB PE=3 S...	337.0	[0..4]	[291..10]
gi\|95109017 - gi\|95109017\|emb\|CAK13713.1\| tRNA pseudouridine 55 synthase [Pseudomonas entomophila L48] TRUB_PSEE4 - tRNA pseudouridine synthase B OS=Pseudomonas entomophila (strain L48) GN=truB PE=3 SV=1	336.0	[0..4]	[291..10]
TRUB_HAEI8 - tRNA pseudouridine synthase B OS=Haemophilus influenzae (strain 86-028NP) GN=truB PE=3 SV=1	335.0	[0..6]	[292..12]
gi\|229810304, gi... - gi\|229846815\|ref\|ZP_04466922.1\| tRNA pseudouridine synthase B [Haemophilus influenzae 7P49H1], gi\|22... gi\|53732694 - gi\|53732694\|ref\|ZP_00154924.2\| COG0130: Pseudouridine synthase [Haemophilus influenzae R2846] TRUB_HAEIE - tRNA pseudouridine synthase B OS=Haemophilus influenzae (strain PittEE) GN=truB PE=3 SV=1	335.0	[0..6]	[292..12]

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Predicted Domain #1

Region A:
Residues: [1-316]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSATGPGIVV IDKPAGMTSH DVVGRCRRIF ATRRVGHAGT LDPMATGVLV IGIERATKIL  60
   61 GLLTAAPKSY AATIRLGQTT STEDAEGQVL QSVPAKHLTI EAIDAAMERL RGEIRQVPSS 120
  121 VSAIKVGGRR AYRLARQGRS VQLEARPIRI DRFELLAARR RDQLIDIDVE IDCSSGTYIR 180
  181 ALARDLGDAL GVGGHVTALR RTRVGRFELD QARSLDDLAE RPALSLSLDE ACLLMFARRD 240
  241 LTAAEASAAA NGRSLPAVGI DGVYAACDAD GRVIALLRDE GSRTRSVAVL RPATMHPGGV 300
  301 PRGKLAAALE HHHHHH

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	90.09691
Match:	1sgvA
Description:	STRUCTURE OF TRNA PSI55 PSEUDOURIDINE SYNTHASE (TRUB)
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
pseudouridine synthase activity	5.60483019625575	bayes_pls_golite062009
intramolecular transferase activity	4.62815459483632	bayes_pls_golite062009
isomerase activity	3.43067391737824	bayes_pls_golite062009
catalytic activity	2.39224964671205	bayes_pls_golite062009
ligase activity	0.636073507077293	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: