YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|17943410, gi\|...
Organism:	Homo sapiens
Length:	272 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|17943410, gi|....

Description	E-value	Query Range	Subject Range
gi\|20807045, gi\|... - gi\|20807045\|ref\|NP_622216.1\| 3-hydroxybutyryl-CoA dehydratase [Thermoanaerobacter tengcongensis MB4]... gi\|20807045 - gi\|20807045\|ref\|NP_622216.1\| enoyl-CoA hydratase [Thermoanaerobacter tengcongensis MB4]	311.0	[0..14]	[271..6]
gi\|88926146, gi\|... - gi\|88944140\|ref\|ZP_01147473.1\| putative crotonase [Desulfotomaculum reducens MI-1], gi\|88926146\|gb\|E...	308.0	[0..12]	[272..4]
gi\|77997022, gi\|... - gi\|78044907\|ref\|YP_360429.1\| 3-hydroxybutyryl-CoA dehydratase [Carboxydothermus hydrogenoformans Z-2...	303.0	[0..13]	[272..5]
gi\|1903327 - gi\|1903327\|emb\|CAB07495.1\| crotonase [Thermoanaerobacterium thermosaccharolyticum] gi\|1903327\|emb\|C... - crotonase [Thermoanaerobacterium thermosaccharolyticum]	301.0	[0..14]	[272..6]
gi\|18145966, gi\|... - gi\|18311283\|ref\|NP_563217.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens str. 13], gi\|... gi\|110673862, gi... - gi\|110799215\|ref\|YP_696975.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens ATCC 13124],... gi\|182625533, gi... - gi\|182625533\|ref\|ZP_02953304.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens D str. JGS... gi\|170715197, gi... - gi\|170715197\|gb\|EDT27379.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens CPE str. F4969...	300.0	[0..14]	[272..6]
gi\|110683900, gi... - gi\|110803399\|ref\|YP_699562.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium perfringens SM101], gi\|1...	300.0	[0..14]	[272..6]
gi\|70606884, gi\|... - gi\|70606884\|ref\|YP_255754.1\| 3-hydroxybutyryl-CoA dehydrogenase [Sulfolobus acidocaldarius DSM 639],...	299.0	[0..13]	[272..410]
gi\|28202663, gi\|... - gi\|28210227\|ref\|NP_781171.1\| 3-hydroxybutyryl-CoA dehydratase [Clostridium tetani E88], gi\|28202663\|...	298.0	[0..10]	[271..1]
gi\|15622596, gi\|... - gi\|15921809\|ref\|NP_377478.1\| 3-hydroxybutyryl-CoA dehydratase [Sulfolobus tokodaii str. 7], gi\|15622...	297.0	[0..7]	[272..9]

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Predicted Domain #1

Region A:
Residues: [1-272]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SSEMKTEDEL RVRHLEEENR GIVVLGINRA YGKNSLSKNL IKMLSKAVDA LKSDKKVRTI  60
   61 IIRSEVPGIF CAGADLKERA KMSSSEVGPF VSKIRAVIND IANLPVPTIA AIDGLALGGG 120
  121 LELALACDIR VAASSAKMGL VETKLAIIPG GGGTQRLPRA IGMSLAKELI FSARVLDGKE 180
  181 AKAVGLISHV LEQNQEGDAA YRKALDLARE FLPQGPVAMR VAKLAINQGM EVDLVTGLAI 240
  241 EEACYAQTIP TKDRLEGLLA FKEKRPPRYK GE

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Detection Method:	PSI-BLAST
Confidence:	63.30103
Match:	1hzdA
Description:	AUH protein
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
enoyl-CoA hydratase activity	3.92947460544831	bayes_pls_golite062009
CoA carboxylase activity	3.59076614105466	bayes_pls_golite062009
ligase activity, forming carbon-carbon bonds	3.4980371783229	bayes_pls_golite062009
acetyl-CoA carboxylase activity	3.34692152434862	bayes_pls_golite062009
3-hydroxyacyl-CoA dehydrogenase activity	2.44182589784656	bayes_pls_golite062009
dodecenoyl-CoA delta-isomerase activity	1.80820904754223	bayes_pls_golite062009
catalytic activity	1.46154163027498	bayes_pls_golite062009
propionyl-CoA carboxylase activity	1.20853698666984	bayes_pls_golite062009
long-chain-3-hydroxyacyl-CoA dehydrogenase activity	1.03484393216342	bayes_pls_golite062009
ligase activity	0.98581896521131	bayes_pls_golite062009
RNA binding	0.599974851773164	bayes_pls_golite062009
binding	0.578223105269736	bayes_pls_golite062009
long-chain-enoyl-CoA hydratase activity	0.571617594666499	bayes_pls_golite062009
nucleic acid binding	0.472835473017362	bayes_pls_golite062009
3-hydroxybutyryl-CoA epimerase activity	0.241955774397835	bayes_pls_golite062009
hydrolase activity	0.167287221009063	bayes_pls_golite062009
racemase and epimerase activity, acting on hydroxy acids and derivatives	0.099208209617217	bayes_pls_golite062009
intramolecular oxidoreductase activity, transposing C=C bonds	0.0918189681606029	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: