YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|5822323, gi\|5...
Organism:	Homo sapiens
Length:	264 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|5822323, gi|5....

Description	E-value	Query Range	Subject Range
gi\|114583680 - gi\|114583680\|ref\|XP_001134895.1\| PREDICTED: insulin receptor substrate 1 isoform 2 [Pan troglodytes]	211.0	[0..1]	[264..4]
IRS1_CHLAE - Insulin receptor substrate 1 OS=Chlorocebus aethiops GN=IRS1 PE=2 SV=1	211.0	[0..1]	[264..4]
gi\|76629914, gi\|... - gi\|76629914\|ref\|XP_884130.1\| PREDICTED: similar to insulin receptor substrate 1 isoform 2 [Bos tauru...	211.0	[0..1]	[264..4]
IRS1 - insulin receptor substrate 1 gi\|168270828, gi... - gi\|190689515\|gb\|ACE86532.1\| insulin receptor substrate 1 protein [synthetic construct], gi\|168270828...	211.0	[0..1]	[264..4]
gi\|73994094 - gi\|73994094\|ref\|XP_543274.2\| PREDICTED: similar to insulin receptor substrate 1 [Canis familiaris]	210.0	[0..1]	[264..4]
gi\|109101277 - gi\|109101277\|ref\|XP_001109882.1\| PREDICTED: similar to insulin receptor substrate 1 [Macaca mulatta]	210.0	[0..1]	[264..4]
gi\|51317288 - gi\|51317288\|gb\|AAT99886.1\| insulin receptor substrate-1 [Sus scrofa]	204.0	[0..8]	[264..1]
IRS1_RAT - Insulin receptor substrate 1 OS=Rattus norvegicus GN=Irs1 PE=1 SV=1	202.0	[0..1]	[264..4]

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Predicted Domain #1

Region A:
Residues: [1-264]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 PPESDGFSDV RKVGYLRKPK SMHKRFFVLR AASEAGGPAR LEYYENEKKW RHKSSAPKRS  60
   61 IPLESCFNIN KRADSKNKHL VALYTRDEHF AIAADSEAEQ DSWYQALLQL HNRAKGHHDG 120
  121 AAALGAGGGG GSCSGSSGLG EAGEDLSYGD VPPGPAFKEV WQVILKPKGL GQTKNLIGIY 180
  181 RLCLTSKTIS FVKLNSEAAA VVLQLMNIRR CGHSENFFFI EVGRSAVTGP GEFWMQVDDS 240
  241 VVAQNMHETI LEAMRAMSDE FRPR

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	55.09691
Match:	1qqgA
Description:	Insulin receptor substrate 1, IRS-1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
binding	0.597587183571285	bayes_pls_golite062009
protein binding	0.29116370406325	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: