YRC Public Data Repository - Protein Structure Prediction

Protein:	gi\|1633322, gi\|1...
Organism:	Homo sapiens
Length:	184 amino acids
Reference:	Drew K, et al. (2011) The proteome folding project: Proteome-scale prediction of structure and function. Genome Res. 2011 Sep 16

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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for gi|1633322, gi|1....

Description	E-value	Query Range	Subject Range
DUS3_PONAB - Dual specificity protein phosphatase 3 OS=Pongo abelii GN=DUSP3 PE=2 SV=1 DUS3_PONPY - Dual specificity protein phosphatase 3 - Pongo pygmaeus (Orangutan) gi\|55645647 - gi\|55645647\|ref\|XP_523660.1\| PREDICTED: hypothetical protein LOC468271 isoform 3 [Pan troglodytes] gi\|109116141 - gi\|109116141\|ref\|XP_001113754.1\| PREDICTED: dual specificity phosphatase 3 (vaccinia virus phosphata... DUSP3 - dual specificity phosphatase 3 CCDS11469.1_1 - null gi\|61356498, gi\|... - gi\|61356498\|gb\|AAX41252.1\| dual specificity phosphatase 3 [synthetic construct], gi\|123999779\|gb\|ABM...	189.0	[0..1]	[184..2]
gi\|54695912, gi\|... - gi\|61366329\|gb\|AAX42844.1\| dual specificity phosphatase 3 [synthetic construct], gi\|54695912\|gb\|AAV3...	189.0	[0..1]	[184..2]
gi\|109491956, gi... - gi\|62657092\|ref\|XP_573199.1\| PREDICTED: similar to Dual specificity protein phosphatase 3 (T-DSP11) ...	182.0	[0..1]	[183..88]
gi\|73965594 - gi\|73965594\|ref\|XP_537624.2\| PREDICTED: similar to Dual specificity protein phosphatase 3 (Dual spec...	180.0	[0..2]	[183..46]
DUS3_MOUSE - Dual specificity protein phosphatase 3 OS=Mus musculus GN=Dusp3 PE=1 SV=1	179.0	[0..1]	[183..2]
IPI00790757, IPI... - Tax_Id=9606 23 kDa protein, IPI:IPI00790757.1\|VEGA:OTTHUMP00000181836 Tax_Id=9606 Gene_Symbol=DUSP3 ... gi\|114666937 - gi\|114666937\|ref\|XP_001153398.1\| PREDICTED: hypothetical protein LOC468271 isoform 1 [Pan troglodyte...	175.0	[0..1]	[184..2]
gi\|83405412, gi\|... - gi\|83405412\|gb\|AAI11277.1\| Dual specificity phosphatase 3 [Bos taurus], gi\|115496842\|ref\|NP_00106984...	172.0	[0..1]	[183..2]
gi\|72038871, gi\|... - gi\|72038871\|ref\|XP_791989.1\| PREDICTED: hypothetical protein [Strongylocentrotus purpuratus], gi\|115...	163.0	[0..6]	[181..9]

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Predicted Domain #1

Region A:
Residues: [1-184]

      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 SGSFELSVQD LNDLLSDGSG CYSLPSQPCN EVTPRIYVGN ASVAQDIPKL QKLGITHVLN  60
   61 AAEGRSFMHV NTNANFYKDS GITYLGIKAN DTQEFNLSAY FERAADFIDQ ALAQKNGRVL 120
  121 VHCREGYSRS PTLVIAYLMM RQKMDVKSAL SIVRQNREIG PNDGFLAQLC QLNDRLAKEG 180
  181 KLKP

[Run NCBI BLAST on this sequence.]

Detection Method:	PSI-BLAST
Confidence:	48.522879
Match:	1vhrA
Description:	VH1-related dual-specificity phosphatase, VHR
Matching Structure (courtesy of the PDB):

Predicted functions:

Term	Confidence	Notes
phosphoprotein phosphatase activity	7.30669036331612	bayes_pls_golite062009
phosphatase activity	6.6585143972081	bayes_pls_golite062009
phosphoric ester hydrolase activity	6.44546424348532	bayes_pls_golite062009
hydrolase activity, acting on ester bonds	5.70473199778334	bayes_pls_golite062009
protein tyrosine phosphatase activity	5.3097342170423	bayes_pls_golite062009
hydrolase activity	4.08088661270715	bayes_pls_golite062009
transmembrane receptor protein phosphatase activity	2.94635032478625	bayes_pls_golite062009
transmembrane receptor protein tyrosine phosphatase activity	2.94635032478625	bayes_pls_golite062009
protein tyrosine/serine/threonine phosphatase activity	2.77531895423367	bayes_pls_golite062009
protein serine/threonine phosphatase activity	1.95004535887255	bayes_pls_golite062009
binding	1.46731689565365	bayes_pls_golite062009
protein binding	1.2114562222518	bayes_pls_golite062009
inositol or phosphatidylinositol phosphatase activity	1.1200449509328	bayes_pls_golite062009
catalytic activity	1.06283028154109	bayes_pls_golite062009
lipid phosphatase activity	1.05085928819585	bayes_pls_golite062009
non-membrane spanning protein tyrosine phosphatase activity	0.724257798127697	bayes_pls_golite062009
nucleic acid binding	0.438873526795276	bayes_pls_golite062009
protein kinase activity	0.271008536688339	bayes_pls_golite062009
DNA binding	0.168641341125007	bayes_pls_golite062009
phosphotransferase activity, alcohol group as acceptor	0.0776644624761281	bayes_pls_golite062009
kinase activity	0.0715870881653981	bayes_pls_golite062009
transferase activity, transferring phosphorus-containing groups	0.0361995996259996	bayes_pls_golite062009

TMHMM	2.0c	PSIPRED	v2.61
SignalP	3.0	COILS	1999
DISOPRED	v0.1	NCBI nr	06/2007
PSI-BLAST	2.2.18	FFAS	ffas03
PDB	06/2007	Pfam	22
HMMER	2.3.2

View Structure Prediction Details

Top Sequence Alignment Hits

Predicted functions: