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Protein Overview: GCD1

General Information:
Name(s) found: GCD1 / YOR260W [SGD]
Description(s) found:
Found 24 descriptions.
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  • Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 578 amino acids

    Gene Ontology:
    Cellular Component: guanyl-nucleotide exchange factor complex [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    eukaryotic translation initiation factor 2B complex [IDALink to PubMed article]
    Biological Process: regulation of translational initiation [IDALink to PubMed article][IGILink to PubMed article][IMPLink to PubMed articleLink to PubMed articleLink to PubMed articleLink to PubMed article]
    Molecular Function: translation initiation factor activity [IMPLink to PubMed articleLink to PubMed article][IPILink to PubMed article]
    guanyl-nucleotide exchange factor activity [IDALink to PubMed articleLink to PubMed article][IPILink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MSIQAFVFCG KGSNLAPFTQ PDFPFQTQNK DSTAATSGDK LNELVNSALD STVINEFMQH  60
   61 STRLPKALLP IGNRPMIEYV LDWCDQADFK EISVVAPVDE IELIESGLTS FLSLRKQQFE 120
  121 LIYKALSNSN HSHHLQDPKK INFIPSKANS TGESLQKELL PRINGDFVIL PCDFVTDIPP 180
  181 QVLVDQFRNR DDNNLAMTIY YKNSLDSSID KKQQQKQKQQ QFFTVYSENE DSERQPILLD 240
  241 VYSQRDVTKT KYLQIRSHLL WNYPNLTVST KLLNSFIYFC SFELCQLLKL GPQSMSRQAS 300
  301 FKDPFTGNQQ QQNPPTTDDD EDRNHDDDDD YKPSATSIQP TYFKKKNDLI LDPINCNKSL 360
  361 SKVFRDLSRR SWQHSKPREP IGIFILPNET LFIRANNLNA YMDANRFVLK IKSQTMFTKN 420
  421 IQIQSAAIGA DAIVDPKCQI SAHSNVKMSV LGTQANIGSR CRVAGSLLFP GVHLGDEVIL 480
  481 ENCIIGPMAK IGSKCKLSNC YIEGHYVVEP KNNFKGETLA NVYLDEDEED ELIYDDSVIA 540
  541 GESEIAEETD SDDRSDEDSD DSEYTDEYEY EDDGLFER

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CDC123 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 SUI2 SUI3
    View Details (MIPS) Mewes HW, et al. (2004) GCD1 GCD2 GCD6 GCD7 GCN3
    View Details Krogan NJ, et al. (2006) ADE1 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 MRF1 MRH4 SUI2
    View Details Gavin AC, et al. (2006) GCD1 GCD11 GCD2 GCD6 GCD7 GCN3
    View Details Gavin AC, et al. (2002) CCT4 CHC1 COG8 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 GUT1 IST1 PDC1 PRO1 RRP40 RRP46 SUI2 SUI3 XKS1
    View Details Ho Y, et al. (2002) CDC123 CDC33 FAA4 FAL1 FET3 GCD1 GCD11 GCD2 GCD6 GCD7 GCN3 LOS1 MET18 NMD5 PRO3 SCW4 SUI2 SUI3 TIF1, TIF2 TIF4631 TIF4632 TUP1 VAC8 VMA8
    View Details Qiu et al. (2008) GCD1 GCD2 GCD6 GCD7 GCN3

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run BOI1 Sample boi 1 with ha tag from october 2005 McCusker D, et al (2007)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen RAD10 GCD1 2 Uetz P, et al. (2000)

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data GCD1 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..345] PSI-BLAST 84.154902 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain
    2 View Details [346..578] PSI-BLAST 84.154902 N-acetylglucosamine 1-phosphate uridyltransferase GlmU, C-terminal domain; N-acetylglucosamine 1-phosphate uridyltransferase GlmU, N-terminal domain

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • catalytic activity
    		•  1.88676710996045 bayes_pls_golite062009
  • nucleotidyltransferase activity
    		•  1.86990263440735 bayes_pls_golite062009
  • transferase activity
    		•  1.47184463413038 bayes_pls_golite062009
  • transferase activity, transferring phosphorus-containing groups
    		•  0.992215002450258 bayes_pls_golite062009
  • transferase activity, transferring hexosyl groups
    		•  0.796949457473955 bayes_pls_golite062009
  • acyltransferase activity
    		•  0.741838450922005 bayes_pls_golite062009
  • transferase activity, transferring acyl groups other than amino-acyl groups
    		•  0.717805296858439 bayes_pls_golite062009
  • UDP-glycosyltransferase activity
    		•  0.619458068514795 bayes_pls_golite062009
  • transferase activity, transferring acyl groups
    		•  0.555398952276587 bayes_pls_golite062009
  • binding
    		•  0.456682720062287 bayes_pls_golite062009
  • O-acyltransferase activity
    		•  0.319932817519902 bayes_pls_golite062009
    2 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle