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Protein Overview: CTF18

General Information:
Name(s) found: CTF18 / YMR078C [SGD]
Description(s) found:
Found 24 descriptions.
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  • Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 741 amino acids

    Gene Ontology:
    Cellular Component: mitochondrion [IDALink to PubMed articleLink to PubMed article]
    DNA replication factor C complex [IPILink to PubMed article]
    Biological Process: mitotic sister chromatid cohesion [IMPLink to PubMed articleLink to PubMed article]
    Molecular Function: molecular_function [ND]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MVDTAPYIGS LGRSSLFDTG DIEQAPGNNA IGINEEDIHA FVSSTGETVQ LKKKPAKLAT  60
   61 GNISLYTNPD TVWRSDDTYG ININYLLDKI EASGDDRTNA QKTSPITGKI GSDTLWVEKW 120
  121 RPKKFLDLVG NEKTNRRMLG WLRQWTPAVF KEQLPKLPTE KEVSDMELDP LKRPPKKILL 180
  181 LHGPPGIGKT SVAHVIAKQS GFSVSEINAS DERAGPMVKE KIYNLLFNHT FDTNPVCLVA 240
  241 DEIDGSIESG FIRILVDIMQ SDIKATNKLL YGQPDKKDKK RKKKRSKLLT RPIICICNNL 300
  301 YAPSLEKLKP FCEIIAVKRP SDTTLLERLN LICHKENMNI PIKAINDLID LAQGDVRNCI 360
  361 NNLQFLASNV DSRDSSASDK PACAKNTWAS SNKDSPISWF KIVNQLFRKD PHRDIKEQFY 420
  421 ELLNQVELNG NSDRILQGCF NIFPYVKYSD NGIRKPANIS DWLFFHDLMY QSMYAHNGEL 480
  481 LRYSALVPLV FFQTFGDIAN KDDIRMKNSE YEQRELKRAN SDIVSLIMRH ISVQSPLMAS 540
  541 FTDRKSLIFE ILPYLDSMIS SDFNKIRNLK LKQAIMEELV QLLKSFQLNL IQNRSEGFDV 600
  601 RGGLTIDPPI DEVVLLNPKH INEVQHKRAN NLSSLLAKIE ENRAKKRHID QVTEDRLQSQ 660
  661 EMHSKKVKTG LNSSSSTIDF FKNQYGLLKQ TQELEETQKT IGSDETNQAD DCNQTVKIWV 720
  721 KYNEGFSNAV RKNVTWNNLW E

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Riffle et al. (2010) (Unpublished Data) CTF18 CTF8
    View Details Krogan NJ, et al. (2006) AQR1 CTF18 CTF8 DCC1
    View Details Gavin AC, et al. (2002) CTF18 CTF8 DPB2 ELG1 OLA1 POL2 RFC1 RFC2 RFC3 RFC4 RFC5 TOP2 VPS13 YMR181C
    View Details Qiu et al. (2008) CTF18 DCC1

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run CEP3 sample cbf3 from feb 2005 Sandall S, et all (2006)
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #03 Alpha Factor Prep1-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen YBR190W CTF18 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data CTF18 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..122] PSI-BLAST 104.165202 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    2 View Details [123..319] PSI-BLAST 104.165202 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    3 View Details [320..441] PSI-BLAST 104.165202 Membrane fusion atpase p97 N-terminal domain , P97-Nn; Membrane fusion atpase p97, D1 domain; Membrane fusion atpase p97 domain 2, P97-Nc
    4 View Details [442..654] MSA 1.333991 View MSA. No confident structure predictions are available.
    5 View Details [655..741] deduced N/A No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.98

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle