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Protein Overview: STE23

General Information:
Name(s) found: STE23 / YLR389C [SGD]
Description(s) found:
Found 18 descriptions.
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  • Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; member of the insulin-degrading enzyme family [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 1027 amino acids

    Gene Ontology:
    Cellular Component: integral to membrane [TASLink to PubMed article]
    Biological Process: proteolysis [TASLink to PubMed article]
    peptide pheromone maturation [IMPLink to PubMed article][TASLink to PubMed article]
    Molecular Function: metallopeptidase activity [ISSLink to PubMed article][TASLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MGVSLLASSS AFVTKPLLTQ LVHLSPISLN FTVRRFKPFT CLSRYYTTNP YNMTSNFKTF  60
   61 NLDFLKPDLD ERSYRFIELP NKLKALLIQD PKADKAAASL DVNIGAFEDP KNLPGLAHFC 120
  121 EHLLFMGSEK FPDENEYSSY LSKHGGSSNA YTASQNTNYF FEVNHQHLFG ALDRFSGFFS 180
  181 CPLFNKDSTD KEINAVNSEN KKNLQNDIWR IYQLDKSLTN TKHPYHKFST GNIETLGTLP 240
  241 KENGLNVRDE LLKFHKNFYS ANLMKLCILG REDLDTLSDW TYDLFKDVAN NGREVPLYAE 300
  301 PIMQPEHLQK IIQVRPVKDL KKLEISFTVP DMEEHWESKP PRILSHLIGH EGSGSLLAHL 360
  361 KKLGWANELS AGGHTVSKGN AFFAVDIDLT DNGLTHYRDV IVLIFQYIEM LKNSLPQKWI 420
  421 FNELQDISNA TFKFKQAGSP SSTVSSLAKC LEKDYIPVSR ILAMGLLTKY EPDLLTQYTD 480
  481 ALVPENSRVT LISRSLETDS AEKWYGTAYK VVDYPADLIK NMKSPGLNPA LTLPRPNEFV 540
  541 STNFKVDKID GIKPLDEPVL LLSDDVSKLW YKKDDRFWQP RGYIYLSFKL PHTHASIINS 600
  601 MLSTLYTQLA NDALKDVQYD AACADLRISF NKTNQGLAIT ASGFNEKLII LLTRFLQGVN 660
  661 SFEPKKDRFE ILKDKTIRHL KNLLYEVPYS QMSNYYNAII NERSWSTAEK LQVFEKLTFE 720
  721 QLINFIPTIY EGVYFETLIH GNIKHEEALE VDSLIKSLIP NNIHNLQVSN NRLRSYLLPK 780
  781 GKTFRYETAL KDSQNVNSCI QHVTQLDVYS EDLSALSGLF AQLIHEPCFD TLRTKEQLGY 840
  841 VVFSSSLNNH GTANIRILIQ SEHTTPYLEW RINNFYETFG QVLRDMPEED FEKHKEALCN 900
  901 SLLQKFKNMA EESARYTAAI YLGDYNFTHR QKKAKLVANI TKQQMIDFYE NYIMSENASK 960
  961 LILHLKSQVE NKELNENELD TAKYPTGQLI EDVGAFKSTL FVAPVRQPMK DFEISAPPKL1020
 1021 NNSSESE

    Protein Complex Data

      PUBLICATION TOPOLOGY COCOMPLEXED PROTEINS
    View Details Ho Y, et al. (2002) AAC3 BFA1 CYS4 FET4 GND1 GSP1 KEX2 NOP12 PUF6 RLI1 RPF2 SPT2 SRP1 SSF1 STE23 SUP45 TIF4631 UTP22 UTP7
    View Details Qiu et al. (2008) RCE1 STE23

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run MLP2 #29 Asynchronous Prep5-TiO2 Flowthrough Keck JM, et al. (2011)
    View Run MLP2 #10 Mitotic Prep1-TiO2 Phosphopeptide enrichment Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

      BAIT PREY HITS PUBLICATION
    View Screen PRR1 STE23 2 Unpublished Fields Lab Data

    Microscopy / Localization Data

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    No microscopy data found in the PDR for this protein.

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..564] PSI-BLAST 85.0 Mitochondrial processing peptidase (MPP) beta chain
    2 View Details [565..927] PSI-BLAST 15.0 Cytochrome bc1 core subunit 2
    3 View Details [928..1027] MSA 1.339987 View MSA. No confident structure predictions are available.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    [View Details]
    Source: Reynolds et al. 2008. Manuscript submitted Philius confidence legend
    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle