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Protein Overview: PDR8

General Information:
Name(s) found: PDR8 / YLR266C [SGD]
Description(s) found:
Found 23 descriptions.
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  • Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon [SGD]
    • Organism: Saccharomyces cerevisiae
    Length: 701 amino acids

    Gene Ontology:
    Cellular Component: nucleus [IPILink to PubMed article][ISSLink to PubMed article]
    Biological Process: positive regulation of transcription from RNA polymerase II promoter [IGILink to PubMed article][IPILink to PubMed article]
    response to stress [IGILink to PubMed article]
    Molecular Function: DNA binding [IDALink to PubMed article]
    specific RNA polymerase II transcription factor activity [ISSLink to PubMed article]


    Sequence:
    Sequence:
    [PDR BLAST]
    [ProtParam] 
          1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ CVIRKLPQCV  60
   61 YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN NAKPVYCRSS ENPLRSLRTS 120
  121 VLGDNGSRYV FGPTSWKTLS LFEQNKFQTE FQNLWKVLKP LPECTKSQLN ENDVVADLPS 180
  181 FPQMESCIKS FFAGPLFGIL HIFNQDDILS LLDRLFIRDT TDKNLVILLD LQGNAKDKYN 240
  241 LGIVLQILCL GYYNQDIPSS VSHFLHTLSA ASLSSSSSNF VEKLQFFLLS YISVMINCTD 300
  301 GVWDATQGVD LINELCQGCI SLGLNDIDKW YLNESEETKQ NLRCIWFWAL FLDVSTSYDI 360
  361 GNPPSISDDL LDLSIFTAQN FQSPSIDFRR VKLMHDFLDV SRFTTREIHK REMNEKLTTF 420
  421 SLRLIEFIQS NFSPIEHYTN SVYYSDIDPF DILILSRSLS IVASIYNIEM IIAQQSRIID 480
  481 KNRMVQFLLI SISVCVNTMV FHFKEPINDQ ENVLTEGLKL SIILINPLLI RIVSQVYSLA 540
  541 FNRLIFREKA FLFLIDLDTG KKIQFIKYEE ENFDELLTGF DVRTDKFLSF SGTIIRFYEI 600
  601 IDSIFAVNER NKRLLKAVSN FYQLTSTLAF ERVSRVLFDK ASQARIETEK IWLKKGINME 660
  661 HFSDLMIEDF INDVWKTFKE ISKDLWSIDK KKFYKQYHFD L

    Protein Complex Data

    No complex found for this protein.

    Mass Spectrometry Data

    The following runs contain data for this protein:

      BAIT COMMENTS PUBLICATION
    View Run RPA135 No Comments Schneider, DA, et al. (2006)
    View Run MLP2 #25 Asynchronous Prep3-TiO2 Flowthrough Keck JM, et al. (2011)

    Yeast Two-Hybrid Data

    The following interactions contain this protein:

    NOT SHOWING SINGLE HITS. [ Show Single Hits ]

    [View our yeast two-hybrid interpretation guidelines.]

    No yeast two-hybrid interactions found for this protein.

    Microscopy / Localization Data

    New Feature: Upload Your Own Microscopy Data

      PROTEIN(S) PUBLICATION
    View Data PDR8 Huh WK, et al. (2003)

    Protein Structure Data


    [What does the above image mean?]
    [View Top Sequence Alignments] [Show Ginzu Version Information]

    Domains predicted:

    #   Region(s) Method Confidence Match Description
    1 View Details [1..101] PSI-BLAST 68.67837 Hap1 (Cyp1); HAP1
    2 View Details [102..169] deduced N/A No confident structure predictions are available.
    3 View Details [170..446] MSA 6.120992 View MSA. No confident structure predictions are available.
    4 View Details [447..507] deduced N/A Confident ab initio structure predictions are available.
    5 View Details [508..701] MSA 1.026958 View MSA. No confident structure predictions are available.

    Functions predicted (by domain):

    # Gene Ontology predictions
    1
    Term Confidence Notes
  • transcription regulator activity
    		•  4.56444258780502 bayes_pls_golite062009
  • DNA binding
    		•  4.26146437716972 bayes_pls_golite062009
  • nucleic acid binding
    		•  4.17369933547911 bayes_pls_golite062009
  • transcription factor activity
    		•  3.049435548132 bayes_pls_golite062009
  • sequence-specific DNA binding
    		•  2.98081393153291 bayes_pls_golite062009
  • RNA polymerase II transcription factor activity
    		•  2.93914501897006 bayes_pls_golite062009
  • binding
    		•  2.91929847152301 bayes_pls_golite062009
  • specific RNA polymerase II transcription factor activity
    		•  2.44382866473054 bayes_pls_golite062009
  • transcription activator activity
    		•  2.24483536326713 bayes_pls_golite062009
    2 No functions predicted.
    3 No functions predicted.
    4 No functions predicted.
    5 No functions predicted.


    Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076


    Philius Transmembrane Prediction:

    Protein predicted to be: GLOBULAR (No transmembrane regions or signal peptide)
    Confidence of classification: 0.65

    Source: Reynolds et al. (2008)

    YRC Informatics Platform - Version 3.0
    Created and Maintained by: Michael Riffle