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View Structure Prediction Details

Protein: PDR8
Organism: Saccharomyces cerevisiae
Length: 701 amino acids
Reference: Malmström L, et al. (2007) Superfamily assignments for the yeast proteome through integration of structure prediction with the gene ontology. PLoS Biol 5(4): e76. doi:10.1371/journal.pbio.0050076



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Top Sequence Alignment Hits

Listed below are up to the top 10 sequence alignment matches, by species, for the PSI-BLAST search against the protein sequence for PDR8.

Description E-value Query
Range
Subject
Range
PDR8_YEAST - Transcription factor PDR8 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=PDR8 PE=1 SV=1
PDR8 - Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator sup...
0.0 [1..701] [1..701]
gi|2262187 - gi|2262187|gb|AAB63563.1| FacB [Aspergillus niger]
2.0E-75 [8..499] [1..519]
gi|19113716 - gi|19113716|ref|NP_592804.1| hypothetical protein SPAC11D3.07c [Schizosaccharomyces pombe 972h-]
SPAC11D3.07c - transcription factor
2.0E-73 [29..563] [5..545]
gi|2262189 - gi|2262189|gb|AAB63564.1| FacB [Aspergillus oryzae]
2.0E-72 [8..499] [1..516]
gi|2262191 - gi|2262191|gb|AAB63565.1| acetate regulatory DNA binding protein FacB [Emericella nidulans]
gi|67516815, gi|... - gi|67516815|ref|XP_658293.1| hypothetical protein AN0689.2 [Aspergillus nidulans FGSC A4], ref|XP_40...
5.0E-70 [8..499] [1..521]
ACU15_NEUCR - Transcriptional activator protein acu-15 OS=Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS ...
ACU15_NEUCR, AC1... - Transcriptional activator protein acu-15 OS=Neurospora crassa GN=acu-15 PE=1 SV=2, (P87000) Transcri...
8.0E-66 [8..497] [1..537]

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Predicted Domain #1
Region A:
Residues: [1-101]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 MDGSHFPMKS TTGEPVSSGK KGKRRKVIKS CAFCRKRKLK CSQARPMCQQ CVIRKLPQCV  60
   61 YTEEFNYPLS NTELFEQVPN VALVQKIENL QTLLKENDNN N

[Run NCBI BLAST on this sequence.]

Detection Method: PSI-BLAST
Confidence: 68.67837
Match: 1hwtD_
Description: Hap1 (Cyp1); HAP1
Matching Structure (courtesy of the PDB):

Predicted functions:

Term Confidence Notes
transcription regulator activity 4.56444258780502 bayes_pls_golite062009
DNA binding 4.26146437716972 bayes_pls_golite062009
nucleic acid binding 4.17369933547911 bayes_pls_golite062009
transcription factor activity 3.049435548132 bayes_pls_golite062009
sequence-specific DNA binding 2.98081393153291 bayes_pls_golite062009
RNA polymerase II transcription factor activity 2.93914501897006 bayes_pls_golite062009
binding 2.91929847152301 bayes_pls_golite062009
specific RNA polymerase II transcription factor activity 2.44382866473054 bayes_pls_golite062009
transcription activator activity 2.24483536326713 bayes_pls_golite062009

Predicted Domain #2
Region A:
Residues: [102-169]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 AKPVYCRSSE NPLRSLRTSV LGDNGSRYVF GPTSWKTLSL FEQNKFQTEF QNLWKVLKPL  60
   61 PECTKSQL

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #3
Region A:
Residues: [170-446]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NENDVVADLP SFPQMESCIK SFFAGPLFGI LHIFNQDDIL SLLDRLFIRD TTDKNLVILL  60
   61 DLQGNAKDKY NLGIVLQILC LGYYNQDIPS SVSHFLHTLS AASLSSSSSN FVEKLQFFLL 120
  121 SYISVMINCT DGVWDATQGV DLINELCQGC ISLGLNDIDK WYLNESEETK QNLRCIWFWA 180
  181 LFLDVSTSYD IGNPPSISDD LLDLSIFTAQ NFQSPSIDFR RVKLMHDFLD VSRFTTREIH 240
  241 KREMNEKLTT FSLRLIEFIQ SNFSPIEHYT NSVYYSD

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.

Predicted Domain #4
Region A:
Residues: [447-507]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 IDPFDILILS RSLSIVASIY NIEMIIAQQS RIIDKNRMVQ FLLISISVCV NTMVFHFKEP  60
   61 I

[Run NCBI BLAST on this sequence.]

Detection Method: deduced

Shown below is our most confident de novo (Rosetta) prediction for this domain.
Click here to view all matches.

    MCM
Score
SCOP
Match
SCOP Description
View Download 0.936 a.23.1 HSC20 (HSCB), C-terminal oligomerisation domain

Predicted Domain #5
Region A:
Residues: [508-701]
      1          11         21         31         41         51         
      |          |          |          |          |          |          
    1 NDQENVLTEG LKLSIILINP LLIRIVSQVY SLAFNRLIFR EKAFLFLIDL DTGKKIQFIK  60
   61 YEEENFDELL TGFDVRTDKF LSFSGTIIRF YEIIDSIFAV NERNKRLLKA VSNFYQLTST 120
  121 LAFERVSRVL FDKASQARIE TEKIWLKKGI NMEHFSDLMI EDFINDVWKT FKEISKDLWS 180
  181 IDKKKFYKQY HFDL

[Run NCBI BLAST on this sequence.]

Detection Method: MSA

Shown below is our most confident prediction for this domain.
Click here to view all matches.

Found no confident structure predictions for this domain.


YRC Informatics Platform - Version 3.0
Created and Maintained by: Michael Riffle